Haemodynamic parameters of isolated guinea pig hearts at baseline and after application of nitroglycerin (GTN) or 2,2-diethyl-1-nitroso-oxyhydrazine (DEA/NO)
| . | Baseline . | GTN (100 µM) . | DEA/NO (10 µM) . |
|---|---|---|---|
| (A) Control | |||
| LVDevP (mmHg) | 97 ± 4 | 100 ± 4 | 117 ± 6* |
| Heart rate (b.p.m.) | 188 ± 5 | 188 ± 4 | 192 ± 2 |
| (B) Nitrate-tolerant | |||
| LVDevP (mmHg) | 94 ± 5 | 100 ± 8 | 118 ± 8* |
| Heart rate (b.p.m.) | 203 ± 10 | 205 ± 8 | 201 ± 11 |
| (C) Ascorbate-deficient | |||
| LVDevP (mmHg) | 99 ± 5 | 105 ± 2 | 119 ± 2* |
| Heart rate (b.p.m.) | 201 ± 11 | 203 ± 8 | 206 ± 10 |
| (D) Nitrate-tolerant and ascorbate-deficient | |||
| LVDevP (mmHg) | 95 ± 1 | 97 ± 1 | 121 ± 2* |
| Heart rate (b.p.m.) | 201 ± 8 | 196 ± 7 | 201 ± 9 |
| . | Baseline . | GTN (100 µM) . | DEA/NO (10 µM) . |
|---|---|---|---|
| (A) Control | |||
| LVDevP (mmHg) | 97 ± 4 | 100 ± 4 | 117 ± 6* |
| Heart rate (b.p.m.) | 188 ± 5 | 188 ± 4 | 192 ± 2 |
| (B) Nitrate-tolerant | |||
| LVDevP (mmHg) | 94 ± 5 | 100 ± 8 | 118 ± 8* |
| Heart rate (b.p.m.) | 203 ± 10 | 205 ± 8 | 201 ± 11 |
| (C) Ascorbate-deficient | |||
| LVDevP (mmHg) | 99 ± 5 | 105 ± 2 | 119 ± 2* |
| Heart rate (b.p.m.) | 201 ± 11 | 203 ± 8 | 206 ± 10 |
| (D) Nitrate-tolerant and ascorbate-deficient | |||
| LVDevP (mmHg) | 95 ± 1 | 97 ± 1 | 121 ± 2* |
| Heart rate (b.p.m.) | 201 ± 8 | 196 ± 7 | 201 ± 9 |
LVDevP, left ventricular developed pressure. Data are mean values±SEM of three hearts per group.
*P < 0.05 vs. corresponding baseline.
Haemodynamic parameters of isolated guinea pig hearts at baseline and after application of nitroglycerin (GTN) or 2,2-diethyl-1-nitroso-oxyhydrazine (DEA/NO)
| . | Baseline . | GTN (100 µM) . | DEA/NO (10 µM) . |
|---|---|---|---|
| (A) Control | |||
| LVDevP (mmHg) | 97 ± 4 | 100 ± 4 | 117 ± 6* |
| Heart rate (b.p.m.) | 188 ± 5 | 188 ± 4 | 192 ± 2 |
| (B) Nitrate-tolerant | |||
| LVDevP (mmHg) | 94 ± 5 | 100 ± 8 | 118 ± 8* |
| Heart rate (b.p.m.) | 203 ± 10 | 205 ± 8 | 201 ± 11 |
| (C) Ascorbate-deficient | |||
| LVDevP (mmHg) | 99 ± 5 | 105 ± 2 | 119 ± 2* |
| Heart rate (b.p.m.) | 201 ± 11 | 203 ± 8 | 206 ± 10 |
| (D) Nitrate-tolerant and ascorbate-deficient | |||
| LVDevP (mmHg) | 95 ± 1 | 97 ± 1 | 121 ± 2* |
| Heart rate (b.p.m.) | 201 ± 8 | 196 ± 7 | 201 ± 9 |
| . | Baseline . | GTN (100 µM) . | DEA/NO (10 µM) . |
|---|---|---|---|
| (A) Control | |||
| LVDevP (mmHg) | 97 ± 4 | 100 ± 4 | 117 ± 6* |
| Heart rate (b.p.m.) | 188 ± 5 | 188 ± 4 | 192 ± 2 |
| (B) Nitrate-tolerant | |||
| LVDevP (mmHg) | 94 ± 5 | 100 ± 8 | 118 ± 8* |
| Heart rate (b.p.m.) | 203 ± 10 | 205 ± 8 | 201 ± 11 |
| (C) Ascorbate-deficient | |||
| LVDevP (mmHg) | 99 ± 5 | 105 ± 2 | 119 ± 2* |
| Heart rate (b.p.m.) | 201 ± 11 | 203 ± 8 | 206 ± 10 |
| (D) Nitrate-tolerant and ascorbate-deficient | |||
| LVDevP (mmHg) | 95 ± 1 | 97 ± 1 | 121 ± 2* |
| Heart rate (b.p.m.) | 201 ± 8 | 196 ± 7 | 201 ± 9 |
LVDevP, left ventricular developed pressure. Data are mean values±SEM of three hearts per group.
*P < 0.05 vs. corresponding baseline.
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