Table 2 Open in new tab Predictors of...

Characteristic	Hazard ratio for new-onset AF (95% confidence interval)
Univariate analysis
Post-discharge ACEI/ARB use within 1 month	1.16 (1.11–1.21)*	1.01 (0.95–1.07)
Multivariable analysis
Post-discharge ACEI/ARB use within 1 month	0.99 (0.94–1.04)	1.01 (0.95–1.07)
Patient characteristics
Patient age (per additional year)	1.03 (1.02–1.03)*	1.03 (1.02–1.03)*
Male gender	1.19 (1.13–1.25)*	1.23 (1.15–1.31)*
White race	1.16 (1.08–1.26)*	1.21 (1.08–1.35)*
Year of admission (per additional year)	1.00 (0.99–1.01)	1.00 (0.98–1.01)
Diabetes mellitus	1.16 (1.11–1.21)*	1.16 (1.09–1.23)*
Peripheral vascular disease	1.14 (1.03–1.26)*	1.12 (1.00–1.27)*
Congestive heart failure	1.57 (1.49–1.64)*	1.58 (1.48–1.69)*
Stroke	1.17 (1.08–1.27)*	1.16 (1.04–1.30)*
Previous myocardial infarction	0.93 (0.88–0.98)	0.94 (0.87–1.01)
Previous CABG or PCI	1.04 (0.92–1.16)	1.04 (0.90–1.21)
Chronic kidney disease	1.22 (1.16–1.28)*	1.24 (1.16–1.32)*
Hypertension	1.03 (0.97–1.10)	1.04 (0.95–1.14)
Hospital length of stay (per additional day)	1.00 (1.00–1.01)	1.01 (1.00–1.01)
Hospital characteristic
Teaching hospital	0.96 (0.92–1.00)	0.98 (0.92–1.04)
Pre-hospital medications
ACEI/ARB	1.14 (1.08–1.20)*	1.15 (1.08, 1.24)*
Beta-blocker	0.98 (0.94–1.03)	0.96 (0.90–1.02)
Statin	0.98 (0.93–1.04)	0.97 (0.90–1.04)
Post-hospital medications
Statin	0.92 (0.86–0.98)	0.94 (0.86–1.02)
Beta-blocker	0.94 (0.89–0.98)	0.98 (0.92–1.05)
Calcium channel blockers	1.13 (1.08–1.19)*	1.10 (1.02–1.18)*
Digoxin	1.42 (1.32–1.53)*	1.35 (1.22–1.48)*

Characteristic

Hazard ratio for new-onset AF (95% confidence interval)

Entire cohort (N = 28 620)

Propensity-matched cohort (N = 15 174)

Univariate analysis

Post-discharge ACEI/ARB use within 1 month

1.16 (1.11–1.21)*

1.01 (0.95–1.07)

Multivariable analysis

Post-discharge ACEI/ARB use within 1 month

0.99 (0.94–1.04)

1.01 (0.95–1.07)

Patient characteristics

Patient age (per additional year)

1.03 (1.02–1.03)*

Male gender

1.19 (1.13–1.25)*

1.23 (1.15–1.31)*

White race

1.16 (1.08–1.26)*

1.21 (1.08–1.35)*

Year of admission (per additional year)

1.00 (0.99–1.01)

1.00 (0.98–1.01)

Diabetes mellitus

1.16 (1.11–1.21)*

1.16 (1.09–1.23)*

Peripheral vascular disease

1.14 (1.03–1.26)*

1.12 (1.00–1.27)*

Congestive heart failure

1.57 (1.49–1.64)*

1.58 (1.48–1.69)*

Stroke

1.17 (1.08–1.27)*

1.16 (1.04–1.30)*

Previous myocardial infarction

0.93 (0.88–0.98)

0.94 (0.87–1.01)

Previous CABG or PCI

1.04 (0.92–1.16)

1.04 (0.90–1.21)

Chronic kidney disease

1.22 (1.16–1.28)*

1.24 (1.16–1.32)*

Hypertension

1.03 (0.97–1.10)

1.04 (0.95–1.14)

Hospital length of stay (per additional day)

1.00 (1.00–1.01)

1.01 (1.00–1.01)

Hospital characteristic

Teaching hospital

0.96 (0.92–1.00)

0.98 (0.92–1.04)

Pre-hospital medications

ACEI/ARB

1.14 (1.08–1.20)*

1.15 (1.08, 1.24)*

Beta-blocker

0.98 (0.94–1.03)

0.96 (0.90–1.02)

Statin

0.98 (0.93–1.04)

0.97 (0.90–1.04)

Post-hospital medications

Statin

0.92 (0.86–0.98)

0.94 (0.86–1.02)

Beta-blocker

0.94 (0.89–0.98)

0.98 (0.92–1.05)

Calcium channel blockers

1.13 (1.08–1.19)*

1.10 (1.02–1.18)*

Digoxin

1.42 (1.32–1.53)*

1.35 (1.22–1.48)*

Characteristic	Hazard ratio for new-onset AF (95% confidence interval)
Univariate analysis
Post-discharge ACEI/ARB use within 1 month	1.16 (1.11–1.21)*	1.01 (0.95–1.07)
Multivariable analysis
Post-discharge ACEI/ARB use within 1 month	0.99 (0.94–1.04)	1.01 (0.95–1.07)
Patient characteristics
Patient age (per additional year)	1.03 (1.02–1.03)*	1.03 (1.02–1.03)*
Male gender	1.19 (1.13–1.25)*	1.23 (1.15–1.31)*
White race	1.16 (1.08–1.26)*	1.21 (1.08–1.35)*
Year of admission (per additional year)	1.00 (0.99–1.01)	1.00 (0.98–1.01)
Diabetes mellitus	1.16 (1.11–1.21)*	1.16 (1.09–1.23)*
Peripheral vascular disease	1.14 (1.03–1.26)*	1.12 (1.00–1.27)*
Congestive heart failure	1.57 (1.49–1.64)*	1.58 (1.48–1.69)*
Stroke	1.17 (1.08–1.27)*	1.16 (1.04–1.30)*
Previous myocardial infarction	0.93 (0.88–0.98)	0.94 (0.87–1.01)
Previous CABG or PCI	1.04 (0.92–1.16)	1.04 (0.90–1.21)
Chronic kidney disease	1.22 (1.16–1.28)*	1.24 (1.16–1.32)*
Hypertension	1.03 (0.97–1.10)	1.04 (0.95–1.14)
Hospital length of stay (per additional day)	1.00 (1.00–1.01)	1.01 (1.00–1.01)
Hospital characteristic
Teaching hospital	0.96 (0.92–1.00)	0.98 (0.92–1.04)
Pre-hospital medications
ACEI/ARB	1.14 (1.08–1.20)*	1.15 (1.08, 1.24)*
Beta-blocker	0.98 (0.94–1.03)	0.96 (0.90–1.02)
Statin	0.98 (0.93–1.04)	0.97 (0.90–1.04)
Post-hospital medications
Statin	0.92 (0.86–0.98)	0.94 (0.86–1.02)
Beta-blocker	0.94 (0.89–0.98)	0.98 (0.92–1.05)
Calcium channel blockers	1.13 (1.08–1.19)*	1.10 (1.02–1.18)*
Digoxin	1.42 (1.32–1.53)*	1.35 (1.22–1.48)*

Table 2

Open in new tab

Predictors of new-onset atrial fibrillation after hospital admission for coronary artery disease

Characteristic	Hazard ratio for new-onset AF (95% confidence interval)
	Entire cohort (N = 28 620)	Propensity-matched cohort (N = 15 174)
Univariate analysis
Post-discharge ACEI/ARB use within 1 month	1.16 (1.11–1.21)*	1.01 (0.95–1.07)
Multivariable analysis
Post-discharge ACEI/ARB use within 1 month	0.99 (0.94–1.04)	1.01 (0.95–1.07)
Patient characteristics
Patient age (per additional year)	1.03 (1.02–1.03)*	1.03 (1.02–1.03)*
Male gender	1.19 (1.13–1.25)*	1.23 (1.15–1.31)*
White race	1.16 (1.08–1.26)*	1.21 (1.08–1.35)*
Year of admission (per additional year)	1.00 (0.99–1.01)	1.00 (0.98–1.01)
Diabetes mellitus	1.16 (1.11–1.21)*	1.16 (1.09–1.23)*
Peripheral vascular disease	1.14 (1.03–1.26)*	1.12 (1.00–1.27)*
Congestive heart failure	1.57 (1.49–1.64)*	1.58 (1.48–1.69)*
Stroke	1.17 (1.08–1.27)*	1.16 (1.04–1.30)*
Previous myocardial infarction	0.93 (0.88–0.98)	0.94 (0.87–1.01)
Previous CABG or PCI	1.04 (0.92–1.16)	1.04 (0.90–1.21)
Chronic kidney disease	1.22 (1.16–1.28)*	1.24 (1.16–1.32)*
Hypertension	1.03 (0.97–1.10)	1.04 (0.95–1.14)
Hospital length of stay (per additional day)	1.00 (1.00–1.01)	1.01 (1.00–1.01)
Hospital characteristic
Teaching hospital	0.96 (0.92–1.00)	0.98 (0.92–1.04)
Pre-hospital medications
ACEI/ARB	1.14 (1.08–1.20)*	1.15 (1.08, 1.24)*
Beta-blocker	0.98 (0.94–1.03)	0.96 (0.90–1.02)
Statin	0.98 (0.93–1.04)	0.97 (0.90–1.04)
Post-hospital medications
Statin	0.92 (0.86–0.98)	0.94 (0.86–1.02)
Beta-blocker	0.94 (0.89–0.98)	0.98 (0.92–1.05)
Calcium channel blockers	1.13 (1.08–1.19)*	1.10 (1.02–1.18)*
Digoxin	1.42 (1.32–1.53)*	1.35 (1.22–1.48)*

Characteristic	Hazard ratio for new-onset AF (95% confidence interval)
	Entire cohort (N = 28 620)	Propensity-matched cohort (N = 15 174)
Univariate analysis
Post-discharge ACEI/ARB use within 1 month	1.16 (1.11–1.21)*	1.01 (0.95–1.07)
Multivariable analysis
Post-discharge ACEI/ARB use within 1 month	0.99 (0.94–1.04)	1.01 (0.95–1.07)
Patient characteristics
Patient age (per additional year)	1.03 (1.02–1.03)*	1.03 (1.02–1.03)*
Male gender	1.19 (1.13–1.25)*	1.23 (1.15–1.31)*
White race	1.16 (1.08–1.26)*	1.21 (1.08–1.35)*
Year of admission (per additional year)	1.00 (0.99–1.01)	1.00 (0.98–1.01)
Diabetes mellitus	1.16 (1.11–1.21)*	1.16 (1.09–1.23)*
Peripheral vascular disease	1.14 (1.03–1.26)*	1.12 (1.00–1.27)*
Congestive heart failure	1.57 (1.49–1.64)*	1.58 (1.48–1.69)*
Stroke	1.17 (1.08–1.27)*	1.16 (1.04–1.30)*
Previous myocardial infarction	0.93 (0.88–0.98)	0.94 (0.87–1.01)
Previous CABG or PCI	1.04 (0.92–1.16)	1.04 (0.90–1.21)
Chronic kidney disease	1.22 (1.16–1.28)*	1.24 (1.16–1.32)*
Hypertension	1.03 (0.97–1.10)	1.04 (0.95–1.14)
Hospital length of stay (per additional day)	1.00 (1.00–1.01)	1.01 (1.00–1.01)
Hospital characteristic
Teaching hospital	0.96 (0.92–1.00)	0.98 (0.92–1.04)
Pre-hospital medications
ACEI/ARB	1.14 (1.08–1.20)*	1.15 (1.08, 1.24)*
Beta-blocker	0.98 (0.94–1.03)	0.96 (0.90–1.02)
Statin	0.98 (0.93–1.04)	0.97 (0.90–1.04)
Post-hospital medications
Statin	0.92 (0.86–0.98)	0.94 (0.86–1.02)
Beta-blocker	0.94 (0.89–0.98)	0.98 (0.92–1.05)
Calcium channel blockers	1.13 (1.08–1.19)*	1.10 (1.02–1.18)*
Digoxin	1.42 (1.32–1.53)*	1.35 (1.22–1.48)*

*P< 0.05.

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