Table 3

Prognostic performance of the high-risk SCORE (≥5 vs. <5%)

 MONICA men
HAPIEE men
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)33.5 (5.26)72.4 (5.78)69.0 (5.43)83.1 (5.03)138.1 (5.36)199.7 (7.51)254.7 (7.37)294.4 (9.07)
Observed (O) deaths, N (%)32 (5.03)86 (6.68)62 (4.89)58 (3.51)181 (7.03)37 (1.39)34 (0.98)105 (3.23)
P/O ratio1.050.871.111.430.765.407.522.81
Estimated (E) deaths, N (%)*74.0 (2.78)94.2 (2.73)279.3 (8.60)
P/E ratio2.702.701.06
Sensitivity0.780.790.710.720.650.950.790.94
Specificity0.590.540.560.600.580.370.390.33
PPV0.090.110.080.060.110.020.010.05
NPV0.980.970.970.980.960.990.990.99
Harrell's C0.690.670.630.670.620.660.600.63

 MONICA women
HAPIEE women
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)12.5 (1.78)22.6 (1.96)24.6 (1.68)26.4 (1.60)44.7 (1.67)85.0 (2.53)92.0 (2.45)124.6 (3.08)
Observed (O) deaths, N (%)13 (1.85)21 (1.82)19 (1.30)26 (1.58)86 (3.21)19 (0.57)16 (0.43)42 (1.04)
P/O ratio0.961.081.291.010.524.445.702.96
Estimated (E) deaths, N (%)*41.2 (1.23)37.3 (0.99)139.0 (3.44)
P/E ratio2.062.480.90
Sensitivity0.390.190.260.310.370.420.630.71
Specificity0.890.880.920.920.920.830.840.76
PPV0.060.030.040.060.130.010.020.03
NPV0.990.980.990.990.980.990.990.99
Harrell's C0.640.540.590.610.640.630.740.74
 MONICA men
HAPIEE men
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)33.5 (5.26)72.4 (5.78)69.0 (5.43)83.1 (5.03)138.1 (5.36)199.7 (7.51)254.7 (7.37)294.4 (9.07)
Observed (O) deaths, N (%)32 (5.03)86 (6.68)62 (4.89)58 (3.51)181 (7.03)37 (1.39)34 (0.98)105 (3.23)
P/O ratio1.050.871.111.430.765.407.522.81
Estimated (E) deaths, N (%)*74.0 (2.78)94.2 (2.73)279.3 (8.60)
P/E ratio2.702.701.06
Sensitivity0.780.790.710.720.650.950.790.94
Specificity0.590.540.560.600.580.370.390.33
PPV0.090.110.080.060.110.020.010.05
NPV0.980.970.970.980.960.990.990.99
Harrell's C0.690.670.630.670.620.660.600.63

 MONICA women
HAPIEE women
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)12.5 (1.78)22.6 (1.96)24.6 (1.68)26.4 (1.60)44.7 (1.67)85.0 (2.53)92.0 (2.45)124.6 (3.08)
Observed (O) deaths, N (%)13 (1.85)21 (1.82)19 (1.30)26 (1.58)86 (3.21)19 (0.57)16 (0.43)42 (1.04)
P/O ratio0.961.081.291.010.524.445.702.96
Estimated (E) deaths, N (%)*41.2 (1.23)37.3 (0.99)139.0 (3.44)
P/E ratio2.062.480.90
Sensitivity0.390.190.260.310.370.420.630.71
Specificity0.890.880.920.920.920.830.840.76
PPV0.060.030.040.060.130.010.020.03
NPV0.990.980.990.990.980.990.990.99
Harrell's C0.640.540.590.610.640.630.740.74

CZ, Czech Republic; LT, Lithuania; PL-K, Poland (Krakow); PL-T, Poland (Tarnobrzeg); PL-W, Poland (Warsaw); RU, Russia. CI, confidence interval; HR, hazard ratio; NNP, negative predictive value; PPV, positive predictive value.

*MONICA-based estimations of 10 year CVD mortality in HAPPIEE.

Table 3

Prognostic performance of the high-risk SCORE (≥5 vs. <5%)

 MONICA men
HAPIEE men
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)33.5 (5.26)72.4 (5.78)69.0 (5.43)83.1 (5.03)138.1 (5.36)199.7 (7.51)254.7 (7.37)294.4 (9.07)
Observed (O) deaths, N (%)32 (5.03)86 (6.68)62 (4.89)58 (3.51)181 (7.03)37 (1.39)34 (0.98)105 (3.23)
P/O ratio1.050.871.111.430.765.407.522.81
Estimated (E) deaths, N (%)*74.0 (2.78)94.2 (2.73)279.3 (8.60)
P/E ratio2.702.701.06
Sensitivity0.780.790.710.720.650.950.790.94
Specificity0.590.540.560.600.580.370.390.33
PPV0.090.110.080.060.110.020.010.05
NPV0.980.970.970.980.960.990.990.99
Harrell's C0.690.670.630.670.620.660.600.63

 MONICA women
HAPIEE women
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)12.5 (1.78)22.6 (1.96)24.6 (1.68)26.4 (1.60)44.7 (1.67)85.0 (2.53)92.0 (2.45)124.6 (3.08)
Observed (O) deaths, N (%)13 (1.85)21 (1.82)19 (1.30)26 (1.58)86 (3.21)19 (0.57)16 (0.43)42 (1.04)
P/O ratio0.961.081.291.010.524.445.702.96
Estimated (E) deaths, N (%)*41.2 (1.23)37.3 (0.99)139.0 (3.44)
P/E ratio2.062.480.90
Sensitivity0.390.190.260.310.370.420.630.71
Specificity0.890.880.920.920.920.830.840.76
PPV0.060.030.040.060.130.010.020.03
NPV0.990.980.990.990.980.990.990.99
Harrell's C0.640.540.590.610.640.630.740.74
 MONICA men
HAPIEE men
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)33.5 (5.26)72.4 (5.78)69.0 (5.43)83.1 (5.03)138.1 (5.36)199.7 (7.51)254.7 (7.37)294.4 (9.07)
Observed (O) deaths, N (%)32 (5.03)86 (6.68)62 (4.89)58 (3.51)181 (7.03)37 (1.39)34 (0.98)105 (3.23)
P/O ratio1.050.871.111.430.765.407.522.81
Estimated (E) deaths, N (%)*74.0 (2.78)94.2 (2.73)279.3 (8.60)
P/E ratio2.702.701.06
Sensitivity0.780.790.710.720.650.950.790.94
Specificity0.590.540.560.600.580.370.390.33
PPV0.090.110.080.060.110.020.010.05
NPV0.980.970.970.980.960.990.990.99
Harrell's C0.690.670.630.670.620.660.600.63

 MONICA women
HAPIEE women
CZPL-WPL-TLTRUCZPL-KRU
Predicted (P) deaths, N (%)12.5 (1.78)22.6 (1.96)24.6 (1.68)26.4 (1.60)44.7 (1.67)85.0 (2.53)92.0 (2.45)124.6 (3.08)
Observed (O) deaths, N (%)13 (1.85)21 (1.82)19 (1.30)26 (1.58)86 (3.21)19 (0.57)16 (0.43)42 (1.04)
P/O ratio0.961.081.291.010.524.445.702.96
Estimated (E) deaths, N (%)*41.2 (1.23)37.3 (0.99)139.0 (3.44)
P/E ratio2.062.480.90
Sensitivity0.390.190.260.310.370.420.630.71
Specificity0.890.880.920.920.920.830.840.76
PPV0.060.030.040.060.130.010.020.03
NPV0.990.980.990.990.980.990.990.99
Harrell's C0.640.540.590.610.640.630.740.74

CZ, Czech Republic; LT, Lithuania; PL-K, Poland (Krakow); PL-T, Poland (Tarnobrzeg); PL-W, Poland (Warsaw); RU, Russia. CI, confidence interval; HR, hazard ratio; NNP, negative predictive value; PPV, positive predictive value.

*MONICA-based estimations of 10 year CVD mortality in HAPPIEE.

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