Table 3.
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Turnover Rates of T-cell Subsets

ControlsHIV-2-LVHIV-2-HVHIV-1P Value
Naive T-cells (CD45R0−)
 CD4+
  Peak (%)0.34 (0.30–0.79)0.61 (0.41–0.79)0.53 (0.23–0.93)0.45 (0.25–0.85).520
  p (%/day)0.47 (0.34–0.56)0.44 (0.11–0.72)0.53 (0.20–1.13)0.40 (0.23–0.84).492
  T2 (days)148 (124–229)142 (92–227)137 (69–409)173 (83–336).806
 CD8+
  Peak0.44 (0.22–0.66)0.47 (0.37–0.65)0.66 (0.48–0.96)0.88 (0.47–1.01).019
  p (%/day)0.30 (0.23–0.52)0.38 (0.23–0.80)0.66 (0.45–0.99)0.69 (0.33–1.61).136
  T2 (days)232 (135–312)182 (90–289)105 (72–176)100 (43–210).182
Memory T-cells (CD45RA−)
 CD4+
  Peak (%)1.08 (0.77–1.70)1.46 (1.22–1.94)2.32 (1.12–3.57)1.85 (1.33–3.73).028
  p (%/day)1.30 (1.00–2.47)1.98 (1.30–2.50)1.87 (1.57–6.72)2.36 (1.52–5.19).047
  T2 (days)54 (28–72)35 (28–53)37 (10–44)29 (13–46).055
 CD8+
  Peak (%)0.85 (0.58–1.47)1.50 (0.97–1.82)2.65 (1.47–5.02)1.60 (1.00–3.34).008
  p (%/day)1.55 (0.71–2.06)1.85 (1.20–2.29)3.44 (2.44–7.11)2.24 (1.10–5.27).010
  T2 (days)45 (35–98)38 (30–58)20 (9–28)32 (13–63).031
ControlsHIV-2-LVHIV-2-HVHIV-1P Value
Naive T-cells (CD45R0−)
 CD4+
  Peak (%)0.34 (0.30–0.79)0.61 (0.41–0.79)0.53 (0.23–0.93)0.45 (0.25–0.85).520
  p (%/day)0.47 (0.34–0.56)0.44 (0.11–0.72)0.53 (0.20–1.13)0.40 (0.23–0.84).492
  T2 (days)148 (124–229)142 (92–227)137 (69–409)173 (83–336).806
 CD8+
  Peak0.44 (0.22–0.66)0.47 (0.37–0.65)0.66 (0.48–0.96)0.88 (0.47–1.01).019
  p (%/day)0.30 (0.23–0.52)0.38 (0.23–0.80)0.66 (0.45–0.99)0.69 (0.33–1.61).136
  T2 (days)232 (135–312)182 (90–289)105 (72–176)100 (43–210).182
Memory T-cells (CD45RA−)
 CD4+
  Peak (%)1.08 (0.77–1.70)1.46 (1.22–1.94)2.32 (1.12–3.57)1.85 (1.33–3.73).028
  p (%/day)1.30 (1.00–2.47)1.98 (1.30–2.50)1.87 (1.57–6.72)2.36 (1.52–5.19).047
  T2 (days)54 (28–72)35 (28–53)37 (10–44)29 (13–46).055
 CD8+
  Peak (%)0.85 (0.58–1.47)1.50 (0.97–1.82)2.65 (1.47–5.02)1.60 (1.00–3.34).008
  p (%/day)1.55 (0.71–2.06)1.85 (1.20–2.29)3.44 (2.44–7.11)2.24 (1.10–5.27).010
  T2 (days)45 (35–98)38 (30–58)20 (9–28)32 (13–63).031

Peak is the maximum level of isotope labeling, corrected for glucose enrichment to derive an equivalent for 1 day's labeling; p, modeled proliferation rate constant; T2, doubling time of cells, within that pool, calculated as ln(2)/p. Values are median (IQR). P values by ANOVA; for T2 data was log-transformed.

Abbreviations: ANOVA, analysis of variance; HIV, human immunodeficiency virus; HIV-2-HV, HIV-2 infected with high viral load (>1000 copies/mL); HIV-2-LV, HIV-2 infected with low viral load (<100 copies/mL); IQR, interquartile range.

Table 3.
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Turnover Rates of T-cell Subsets

ControlsHIV-2-LVHIV-2-HVHIV-1P Value
Naive T-cells (CD45R0−)
 CD4+
  Peak (%)0.34 (0.30–0.79)0.61 (0.41–0.79)0.53 (0.23–0.93)0.45 (0.25–0.85).520
  p (%/day)0.47 (0.34–0.56)0.44 (0.11–0.72)0.53 (0.20–1.13)0.40 (0.23–0.84).492
  T2 (days)148 (124–229)142 (92–227)137 (69–409)173 (83–336).806
 CD8+
  Peak0.44 (0.22–0.66)0.47 (0.37–0.65)0.66 (0.48–0.96)0.88 (0.47–1.01).019
  p (%/day)0.30 (0.23–0.52)0.38 (0.23–0.80)0.66 (0.45–0.99)0.69 (0.33–1.61).136
  T2 (days)232 (135–312)182 (90–289)105 (72–176)100 (43–210).182
Memory T-cells (CD45RA−)
 CD4+
  Peak (%)1.08 (0.77–1.70)1.46 (1.22–1.94)2.32 (1.12–3.57)1.85 (1.33–3.73).028
  p (%/day)1.30 (1.00–2.47)1.98 (1.30–2.50)1.87 (1.57–6.72)2.36 (1.52–5.19).047
  T2 (days)54 (28–72)35 (28–53)37 (10–44)29 (13–46).055
 CD8+
  Peak (%)0.85 (0.58–1.47)1.50 (0.97–1.82)2.65 (1.47–5.02)1.60 (1.00–3.34).008
  p (%/day)1.55 (0.71–2.06)1.85 (1.20–2.29)3.44 (2.44–7.11)2.24 (1.10–5.27).010
  T2 (days)45 (35–98)38 (30–58)20 (9–28)32 (13–63).031
ControlsHIV-2-LVHIV-2-HVHIV-1P Value
Naive T-cells (CD45R0−)
 CD4+
  Peak (%)0.34 (0.30–0.79)0.61 (0.41–0.79)0.53 (0.23–0.93)0.45 (0.25–0.85).520
  p (%/day)0.47 (0.34–0.56)0.44 (0.11–0.72)0.53 (0.20–1.13)0.40 (0.23–0.84).492
  T2 (days)148 (124–229)142 (92–227)137 (69–409)173 (83–336).806
 CD8+
  Peak0.44 (0.22–0.66)0.47 (0.37–0.65)0.66 (0.48–0.96)0.88 (0.47–1.01).019
  p (%/day)0.30 (0.23–0.52)0.38 (0.23–0.80)0.66 (0.45–0.99)0.69 (0.33–1.61).136
  T2 (days)232 (135–312)182 (90–289)105 (72–176)100 (43–210).182
Memory T-cells (CD45RA−)
 CD4+
  Peak (%)1.08 (0.77–1.70)1.46 (1.22–1.94)2.32 (1.12–3.57)1.85 (1.33–3.73).028
  p (%/day)1.30 (1.00–2.47)1.98 (1.30–2.50)1.87 (1.57–6.72)2.36 (1.52–5.19).047
  T2 (days)54 (28–72)35 (28–53)37 (10–44)29 (13–46).055
 CD8+
  Peak (%)0.85 (0.58–1.47)1.50 (0.97–1.82)2.65 (1.47–5.02)1.60 (1.00–3.34).008
  p (%/day)1.55 (0.71–2.06)1.85 (1.20–2.29)3.44 (2.44–7.11)2.24 (1.10–5.27).010
  T2 (days)45 (35–98)38 (30–58)20 (9–28)32 (13–63).031

Peak is the maximum level of isotope labeling, corrected for glucose enrichment to derive an equivalent for 1 day's labeling; p, modeled proliferation rate constant; T2, doubling time of cells, within that pool, calculated as ln(2)/p. Values are median (IQR). P values by ANOVA; for T2 data was log-transformed.

Abbreviations: ANOVA, analysis of variance; HIV, human immunodeficiency virus; HIV-2-HV, HIV-2 infected with high viral load (>1000 copies/mL); HIV-2-LV, HIV-2 infected with low viral load (<100 copies/mL); IQR, interquartile range.

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