Changea in 2009 A(H1N1) Pandemic Influenza Virus Hemagglutination Inhibition Antibody Titers After 2010–2011 Trivalent Inactivated Influenza Vaccine by 3 Levels of Preseason Titers Among 834 Healthcare Personnel With All 3 Serum Samples
| Change in HI Titer . | Preseason HI < 10 (n = 398 [48%]) . | Preseason HI 10 to <40 (n = 235 [28%]) . | Preseason HI ≥ 40 (n = 201 [24%]) . |
|---|---|---|---|
| HCP with seroconversionb at post-TIV | 61% | 66% | 33% |
| Mean (95% CI) fold change of HI titers from preseason to post-TIV | 32 (26–37) | 15 (11–18) | 4 (3–5) |
| HCP with HI titer ≥40 at preseason, post-TIV, and end-of-season | 0%; 61%; 35% | 0%; 79%; 43% | 100%; 99%; 96% |
| GMT (geometric SD) of HI titers at preseason, post-TIV, and end-of-season | 5 (1); 49 (5); 18 (4) | 14 (1); 81 (4); 30 (3) | 69 (2); 162 (2); 86 (2) |
| Change in HI Titer . | Preseason HI < 10 (n = 398 [48%]) . | Preseason HI 10 to <40 (n = 235 [28%]) . | Preseason HI ≥ 40 (n = 201 [24%]) . |
|---|---|---|---|
| HCP with seroconversionb at post-TIV | 61% | 66% | 33% |
| Mean (95% CI) fold change of HI titers from preseason to post-TIV | 32 (26–37) | 15 (11–18) | 4 (3–5) |
| HCP with HI titer ≥40 at preseason, post-TIV, and end-of-season | 0%; 61%; 35% | 0%; 79%; 43% | 100%; 99%; 96% |
| GMT (geometric SD) of HI titers at preseason, post-TIV, and end-of-season | 5 (1); 49 (5); 18 (4) | 14 (1); 81 (4); 30 (3) | 69 (2); 162 (2); 86 (2) |
Abbreviation: CI, confidence interval; GMT, geometric mean titer; SD, standard deviation; HCP, healthcare personnel; HI, hemagglutination inhibition; TIV, trivalent inactivated vaccine.
a Change in HI titers among 2010–2011 TIV vaccinees is described from preseason serum to post-TIV and end-of-season.
b Seroconversion was defined as a preseason serum HI titer <10 and a post-TIV serum HI titer ≥40 or a preseason titer ≥10 and a minimum 4-fold rise in HI antibody titer for post-TIV sera.
Changea in 2009 A(H1N1) Pandemic Influenza Virus Hemagglutination Inhibition Antibody Titers After 2010–2011 Trivalent Inactivated Influenza Vaccine by 3 Levels of Preseason Titers Among 834 Healthcare Personnel With All 3 Serum Samples
| Change in HI Titer . | Preseason HI < 10 (n = 398 [48%]) . | Preseason HI 10 to <40 (n = 235 [28%]) . | Preseason HI ≥ 40 (n = 201 [24%]) . |
|---|---|---|---|
| HCP with seroconversionb at post-TIV | 61% | 66% | 33% |
| Mean (95% CI) fold change of HI titers from preseason to post-TIV | 32 (26–37) | 15 (11–18) | 4 (3–5) |
| HCP with HI titer ≥40 at preseason, post-TIV, and end-of-season | 0%; 61%; 35% | 0%; 79%; 43% | 100%; 99%; 96% |
| GMT (geometric SD) of HI titers at preseason, post-TIV, and end-of-season | 5 (1); 49 (5); 18 (4) | 14 (1); 81 (4); 30 (3) | 69 (2); 162 (2); 86 (2) |
| Change in HI Titer . | Preseason HI < 10 (n = 398 [48%]) . | Preseason HI 10 to <40 (n = 235 [28%]) . | Preseason HI ≥ 40 (n = 201 [24%]) . |
|---|---|---|---|
| HCP with seroconversionb at post-TIV | 61% | 66% | 33% |
| Mean (95% CI) fold change of HI titers from preseason to post-TIV | 32 (26–37) | 15 (11–18) | 4 (3–5) |
| HCP with HI titer ≥40 at preseason, post-TIV, and end-of-season | 0%; 61%; 35% | 0%; 79%; 43% | 100%; 99%; 96% |
| GMT (geometric SD) of HI titers at preseason, post-TIV, and end-of-season | 5 (1); 49 (5); 18 (4) | 14 (1); 81 (4); 30 (3) | 69 (2); 162 (2); 86 (2) |
Abbreviation: CI, confidence interval; GMT, geometric mean titer; SD, standard deviation; HCP, healthcare personnel; HI, hemagglutination inhibition; TIV, trivalent inactivated vaccine.
a Change in HI titers among 2010–2011 TIV vaccinees is described from preseason serum to post-TIV and end-of-season.
b Seroconversion was defined as a preseason serum HI titer <10 and a post-TIV serum HI titer ≥40 or a preseason titer ≥10 and a minimum 4-fold rise in HI antibody titer for post-TIV sera.
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