Final population pharmacokinetic parameter estimates for 30 children with CF receiving prolonged-infusion meropenem
| . | Mean . | SD . | Median . |
|---|---|---|---|
| Model-derived pharmacokinetic parameters | |||
| CL0 (L/h/kg) | 0.41 | 0.23 | 0.37 |
| Vc0 (L) | 12.29 | 6.79 | 12.31 |
| Kcp (h−1) | 0.738 | 1.165 | 0.195 |
| Kpc (h−1) | 1.71 | 1.598 | 0.950 |
| Calculated pharmacokinetic parameters | |||
| CL (L/h), CL = CL0 × body weight in kg | 16.14 | 9.25 | 14.31 |
| Vc (L), Vc = Vc0 × body weight in kg/40.9 | 11.57 | 5.60 | 9.88 |
| Vc (L/kg) | 0.30 | 0.17 | 0.30 |
| Vss (L/kg) | 0.43 | 0.34 | 0.38 |
| half-life (h) | 1.11 | 0.38 | 1.00 |
| . | Mean . | SD . | Median . |
|---|---|---|---|
| Model-derived pharmacokinetic parameters | |||
| CL0 (L/h/kg) | 0.41 | 0.23 | 0.37 |
| Vc0 (L) | 12.29 | 6.79 | 12.31 |
| Kcp (h−1) | 0.738 | 1.165 | 0.195 |
| Kpc (h−1) | 1.71 | 1.598 | 0.950 |
| Calculated pharmacokinetic parameters | |||
| CL (L/h), CL = CL0 × body weight in kg | 16.14 | 9.25 | 14.31 |
| Vc (L), Vc = Vc0 × body weight in kg/40.9 | 11.57 | 5.60 | 9.88 |
| Vc (L/kg) | 0.30 | 0.17 | 0.30 |
| Vss (L/kg) | 0.43 | 0.34 | 0.38 |
| half-life (h) | 1.11 | 0.38 | 1.00 |
CL0, clearance; Vc0, allometric volume of distribution of the central compartment; Kcp, microtransfer rate constant from the central compartment to the peripheral compartment; Kpc, microtransfer rate constant from the peripheral compartment to the central compartment; CL, clearance; Vc, volume of distribution of the central compartment, Vss, total volume of distribution at steady state.
Final population pharmacokinetic parameter estimates for 30 children with CF receiving prolonged-infusion meropenem
| . | Mean . | SD . | Median . |
|---|---|---|---|
| Model-derived pharmacokinetic parameters | |||
| CL0 (L/h/kg) | 0.41 | 0.23 | 0.37 |
| Vc0 (L) | 12.29 | 6.79 | 12.31 |
| Kcp (h−1) | 0.738 | 1.165 | 0.195 |
| Kpc (h−1) | 1.71 | 1.598 | 0.950 |
| Calculated pharmacokinetic parameters | |||
| CL (L/h), CL = CL0 × body weight in kg | 16.14 | 9.25 | 14.31 |
| Vc (L), Vc = Vc0 × body weight in kg/40.9 | 11.57 | 5.60 | 9.88 |
| Vc (L/kg) | 0.30 | 0.17 | 0.30 |
| Vss (L/kg) | 0.43 | 0.34 | 0.38 |
| half-life (h) | 1.11 | 0.38 | 1.00 |
| . | Mean . | SD . | Median . |
|---|---|---|---|
| Model-derived pharmacokinetic parameters | |||
| CL0 (L/h/kg) | 0.41 | 0.23 | 0.37 |
| Vc0 (L) | 12.29 | 6.79 | 12.31 |
| Kcp (h−1) | 0.738 | 1.165 | 0.195 |
| Kpc (h−1) | 1.71 | 1.598 | 0.950 |
| Calculated pharmacokinetic parameters | |||
| CL (L/h), CL = CL0 × body weight in kg | 16.14 | 9.25 | 14.31 |
| Vc (L), Vc = Vc0 × body weight in kg/40.9 | 11.57 | 5.60 | 9.88 |
| Vc (L/kg) | 0.30 | 0.17 | 0.30 |
| Vss (L/kg) | 0.43 | 0.34 | 0.38 |
| half-life (h) | 1.11 | 0.38 | 1.00 |
CL0, clearance; Vc0, allometric volume of distribution of the central compartment; Kcp, microtransfer rate constant from the central compartment to the peripheral compartment; Kpc, microtransfer rate constant from the peripheral compartment to the central compartment; CL, clearance; Vc, volume of distribution of the central compartment, Vss, total volume of distribution at steady state.
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