Table 2. Open in new tab Effectiveness...

Treatment	Outcome	Efficacy	Drug/other treatment	Source
Depression
Treatment with older Antidepressants (TCA)	Remission	29%	Amtriptyline (100 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Disability	−31%
Treatment with newer Antidepressants (SSRI)	Remission	28%	Fluoxetine (20 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Disability	−31%
Psychotherapy	Remission	28%	Cognitive therapy (16–20 h)	de Maat et al . (2007) ; Andrews et al . (2000)
Disability	−31%
Comibnation of AD and psychotherapy	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000)
Disability	−31%
Proactive care	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000) ; Geddes et al . (2003)
Disability	−31%
Incidence	−35%
Schizophrenia
Older antipsychotics	Disability	−13%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Leutch et al . (1999)
Newer antipsychotics	Disability	−14%	Risperidone 4 mg daily	Leutch et al . (1999)
Older antipsychotics + psychosocial treatment	Disability	−23%	Chlorpromazine 100 mg daily/Fluphenazine deconate 25 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Newer antipsychotics + psychosocial treatment	Disability	−24%	Risperidone 4 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with older antipsychotics	Disability	−24%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with newer antipsychotics	Disability	−25%	Risperidone 4 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Bipolar disorder
Older mood stabilizer	Disability	−70%	Lithium Carbonate	Goodwin et al. (1990) ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Case-fatality	−65%
Newer mood stabilizer	Disability	−65%	Sodium Valproate	Goodwin et al . (1990) ; Bowden et al 1994 ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Case-fatality	−65%
Older Mood Stabilizer + psychosocial	Disability	−70%	Lithium Carbonate, supportive psychososial treatment	Goodwin et al . (1990) ; Angst et al. (2000) ; Bowden et al . (2000) ; Tondo et al . (2001) ; Lam et al. (2009)
Case-fatality	−65%
Newer mood stabilizer + psychosocial	Disability	−65%	Sodium Valproate, supportive psychosocial treatment	Goodwin et al. (1990) ; Bowden et al . (1994 , 2000) ; Angst et al . (2000) ; Tondo et al . (2001) ; Lam et al (2009)
Case-fatality	−65%
Epilepsy
Older antiepileptic	Remission	60%	Phenobarbital 100 mg daily	Annegers et al . (1979) ; Goodridge, et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Disability	−43%
Newer antiepileptic	Remission	60%	Carbamazepine 600 mg daily	Annegers et al . (1979) ; Goodridge et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Disability	−43 %

Treatment

Outcome

Efficacy

Drug/other treatment

Source

Depression

Treatment with older Antidepressants (TCA)

Remission

29%

Amtriptyline (100 mg daily)

Arroll et al . (2005) ; Andrews et al . (2000)

Disability

−31%

Treatment with newer Antidepressants (SSRI)

Remission

28%

Fluoxetine (20 mg daily)

Arroll et al . (2005) ; Andrews et al . (2000)

Disability

−31%

Psychotherapy

Remission

28%

Cognitive therapy (16–20 h)

de Maat et al . (2007) ; Andrews et al . (2000)

Disability

−31%

Comibnation of AD and psychotherapy

Remission

38%

Amtriptyline/Fluoxetine, cognitive therapy

de Maat et al . (2007) ; Andrews et al . (2000)

Disability

−31%

Proactive care

Remission

38%

Amtriptyline/Fluoxetine, cognitive therapy

de Maat et al . (2007) ; Andrews et al . (2000) ; Geddes et al . (2003)

Disability

−31%

Incidence

−35%

Schizophrenia

Older antipsychotics

Disability

−13%

Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily

Leutch et al . (1999)

Newer antipsychotics

Disability

−14%

Risperidone 4 mg daily

Leutch et al . (1999)

Older antipsychotics + psychosocial treatment

Disability

−23%

Chlorpromazine 100 mg daily/Fluphenazine deconate 25 mg daily, supportive psychosocial treatment

Mojtabai et al . (1998) ; Leutch et al . (1999)

Newer antipsychotics + psychosocial treatment

Disability

−24%

Risperidone 4 mg daily, supportive psychosocial treatment

Mojtabai et al . (1998) ; Leutch et al . (1999)

Case-management with older antipsychotics

Disability

−24%

Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily

Mojtabai et al . (1998) ; Leutch et al . (1999)

Case-management with newer antipsychotics

Disability

−25%

Risperidone 4 mg daily

Mojtabai et al . (1998) ; Leutch et al . (1999)

Bipolar disorder

Older mood stabilizer

Disability

−70%

Lithium Carbonate

Goodwin et al. (1990) ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)

Case-fatality

−65%

Newer mood stabilizer

Disability

−65%

Sodium Valproate

Goodwin et al . (1990) ; Bowden et al 1994 ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)

Case-fatality

−65%

Older Mood Stabilizer + psychosocial

Disability

−70%

Lithium Carbonate, supportive psychososial treatment

Goodwin et al . (1990) ; Angst et al. (2000) ; Bowden et al . (2000) ; Tondo et al . (2001) ; Lam et al. (2009)

Case-fatality

−65%

Newer mood stabilizer + psychosocial

Disability

−65%

Sodium Valproate, supportive psychosocial treatment

Goodwin et al. (1990) ; Bowden et al . (1994 , 2000) ; Angst et al . (2000) ; Tondo et al . (2001) ; Lam et al (2009)

Case-fatality

−65%

Epilepsy

Older antiepileptic

Remission

60%

Phenobarbital 100 mg daily

Annegers et al . (1979) ; Goodridge, et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)

Disability

−43%

Newer antiepileptic

Remission

60%

Carbamazepine 600 mg daily

Annegers et al . (1979) ; Goodridge et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)

Disability

−43 %

Treatment	Outcome	Efficacy	Drug/other treatment	Source
Depression
Treatment with older Antidepressants (TCA)	Remission	29%	Amtriptyline (100 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Disability	−31%
Treatment with newer Antidepressants (SSRI)	Remission	28%	Fluoxetine (20 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Disability	−31%
Psychotherapy	Remission	28%	Cognitive therapy (16–20 h)	de Maat et al . (2007) ; Andrews et al . (2000)
Disability	−31%
Comibnation of AD and psychotherapy	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000)
Disability	−31%
Proactive care	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000) ; Geddes et al . (2003)
Disability	−31%
Incidence	−35%
Schizophrenia
Older antipsychotics	Disability	−13%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Leutch et al . (1999)
Newer antipsychotics	Disability	−14%	Risperidone 4 mg daily	Leutch et al . (1999)
Older antipsychotics + psychosocial treatment	Disability	−23%	Chlorpromazine 100 mg daily/Fluphenazine deconate 25 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Newer antipsychotics + psychosocial treatment	Disability	−24%	Risperidone 4 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with older antipsychotics	Disability	−24%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with newer antipsychotics	Disability	−25%	Risperidone 4 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Bipolar disorder
Older mood stabilizer	Disability	−70%	Lithium Carbonate	Goodwin et al. (1990) ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Case-fatality	−65%
Newer mood stabilizer	Disability	−65%	Sodium Valproate	Goodwin et al . (1990) ; Bowden et al 1994 ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Case-fatality	−65%
Older Mood Stabilizer + psychosocial	Disability	−70%	Lithium Carbonate, supportive psychososial treatment	Goodwin et al . (1990) ; Angst et al. (2000) ; Bowden et al . (2000) ; Tondo et al . (2001) ; Lam et al. (2009)
Case-fatality	−65%
Newer mood stabilizer + psychosocial	Disability	−65%	Sodium Valproate, supportive psychosocial treatment	Goodwin et al. (1990) ; Bowden et al . (1994 , 2000) ; Angst et al . (2000) ; Tondo et al . (2001) ; Lam et al (2009)
Case-fatality	−65%
Epilepsy
Older antiepileptic	Remission	60%	Phenobarbital 100 mg daily	Annegers et al . (1979) ; Goodridge, et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Disability	−43%
Newer antiepileptic	Remission	60%	Carbamazepine 600 mg daily	Annegers et al . (1979) ; Goodridge et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Disability	−43 %

Treatment

Outcome

Efficacy

Drug/other treatment

Source

Depression

Treatment with older Antidepressants (TCA)

Remission

29%

Amtriptyline (100 mg daily)

Arroll et al . (2005) ; Andrews et al . (2000)

Disability

−31%

Treatment with newer Antidepressants (SSRI)

Remission

28%

Fluoxetine (20 mg daily)

Arroll et al . (2005) ; Andrews et al . (2000)

Disability

−31%

Psychotherapy

Remission

28%

Cognitive therapy (16–20 h)

de Maat et al . (2007) ; Andrews et al . (2000)

Disability

−31%

Comibnation of AD and psychotherapy

Remission

38%

Amtriptyline/Fluoxetine, cognitive therapy

de Maat et al . (2007) ; Andrews et al . (2000)

Disability

−31%

Proactive care

Remission

38%

Amtriptyline/Fluoxetine, cognitive therapy

de Maat et al . (2007) ; Andrews et al . (2000) ; Geddes et al . (2003)

Disability

−31%

Incidence

−35%

Schizophrenia

Older antipsychotics

Disability

−13%

Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily

Leutch et al . (1999)

Newer antipsychotics

Disability

−14%

Risperidone 4 mg daily

Leutch et al . (1999)

Older antipsychotics + psychosocial treatment

Disability

−23%

Chlorpromazine 100 mg daily/Fluphenazine deconate 25 mg daily, supportive psychosocial treatment

Mojtabai et al . (1998) ; Leutch et al . (1999)

Newer antipsychotics + psychosocial treatment

Disability

−24%

Risperidone 4 mg daily, supportive psychosocial treatment

Mojtabai et al . (1998) ; Leutch et al . (1999)

Case-management with older antipsychotics

Disability

−24%

Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily

Mojtabai et al . (1998) ; Leutch et al . (1999)

Case-management with newer antipsychotics

Disability

−25%

Risperidone 4 mg daily

Mojtabai et al . (1998) ; Leutch et al . (1999)

Bipolar disorder

Older mood stabilizer

Disability

−70%

Lithium Carbonate

Goodwin et al. (1990) ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)

Case-fatality

−65%

Newer mood stabilizer

Disability

−65%

Sodium Valproate

Goodwin et al . (1990) ; Bowden et al 1994 ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)

Case-fatality

−65%

Older Mood Stabilizer + psychosocial

Disability

−70%

Lithium Carbonate, supportive psychososial treatment

Goodwin et al . (1990) ; Angst et al. (2000) ; Bowden et al . (2000) ; Tondo et al . (2001) ; Lam et al. (2009)

Case-fatality

−65%

Newer mood stabilizer + psychosocial

Disability

−65%

Sodium Valproate, supportive psychosocial treatment

Goodwin et al. (1990) ; Bowden et al . (1994 , 2000) ; Angst et al . (2000) ; Tondo et al . (2001) ; Lam et al (2009)

Case-fatality

−65%

Epilepsy

Older antiepileptic

Remission

60%

Phenobarbital 100 mg daily

Annegers et al . (1979) ; Goodridge, et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)

Disability

−43%

Newer antiepileptic

Remission

60%

Carbamazepine 600 mg daily

Annegers et al . (1979) ; Goodridge et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)

Disability

−43 %

Table 2.

Open in new tab

Effectiveness assumptions

Treatment	Outcome	Efficacy	Drug/other treatment	Source
Depression
Treatment with older Antidepressants (TCA)	Remission	29%	Amtriptyline (100 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Treatment with older Antidepressants (TCA)	Disability	−31%	Amtriptyline (100 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Treatment with newer Antidepressants (SSRI)	Remission	28%	Fluoxetine (20 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Treatment with newer Antidepressants (SSRI)	Disability	−31%	Fluoxetine (20 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Psychotherapy	Remission	28%	Cognitive therapy (16–20 h)	de Maat et al . (2007) ; Andrews et al . (2000)
Psychotherapy	Disability	−31%	Cognitive therapy (16–20 h)	de Maat et al . (2007) ; Andrews et al . (2000)
Comibnation of AD and psychotherapy	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000)
Comibnation of AD and psychotherapy	Disability	−31%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000)
Proactive care	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000) ; Geddes et al . (2003)
	Disability	−31%
	Incidence	−35%
Schizophrenia
Older antipsychotics	Disability	−13%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Leutch et al . (1999)
Newer antipsychotics	Disability	−14%	Risperidone 4 mg daily	Leutch et al . (1999)
Older antipsychotics + psychosocial treatment	Disability	−23%	Chlorpromazine 100 mg daily/Fluphenazine deconate 25 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Newer antipsychotics + psychosocial treatment	Disability	−24%	Risperidone 4 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with older antipsychotics	Disability	−24%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with newer antipsychotics	Disability	−25%	Risperidone 4 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Bipolar disorder
Older mood stabilizer	Disability	−70%	Lithium Carbonate	Goodwin et al. (1990) ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Older mood stabilizer	Case-fatality	−65%	Lithium Carbonate
Newer mood stabilizer	Disability	−65%	Sodium Valproate	Goodwin et al . (1990) ; Bowden et al 1994 ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Newer mood stabilizer	Case-fatality	−65%	Sodium Valproate
Older Mood Stabilizer + psychosocial	Disability	−70%	Lithium Carbonate, supportive psychososial treatment	Goodwin et al . (1990) ; Angst et al. (2000) ; Bowden et al . (2000) ; Tondo et al . (2001) ; Lam et al. (2009)
Older Mood Stabilizer + psychosocial	Case-fatality	−65%	Lithium Carbonate, supportive psychososial treatment
Newer mood stabilizer + psychosocial	Disability	−65%	Sodium Valproate, supportive psychosocial treatment	Goodwin et al. (1990) ; Bowden et al . (1994 , 2000) ; Angst et al . (2000) ; Tondo et al . (2001) ; Lam et al (2009)
Newer mood stabilizer + psychosocial	Case-fatality	−65%	Sodium Valproate, supportive psychosocial treatment
Epilepsy
Older antiepileptic	Remission	60%	Phenobarbital 100 mg daily	Annegers et al . (1979) ; Goodridge, et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Older antiepileptic	Disability	−43%	Phenobarbital 100 mg daily
Newer antiepileptic	Remission	60%	Carbamazepine 600 mg daily	Annegers et al . (1979) ; Goodridge et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Newer antiepileptic	Disability	−43 %	Carbamazepine 600 mg daily

Treatment	Outcome	Efficacy	Drug/other treatment	Source
Depression
Treatment with older Antidepressants (TCA)	Remission	29%	Amtriptyline (100 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Treatment with older Antidepressants (TCA)	Disability	−31%	Amtriptyline (100 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Treatment with newer Antidepressants (SSRI)	Remission	28%	Fluoxetine (20 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Treatment with newer Antidepressants (SSRI)	Disability	−31%	Fluoxetine (20 mg daily)	Arroll et al . (2005) ; Andrews et al . (2000)
Psychotherapy	Remission	28%	Cognitive therapy (16–20 h)	de Maat et al . (2007) ; Andrews et al . (2000)
Psychotherapy	Disability	−31%	Cognitive therapy (16–20 h)	de Maat et al . (2007) ; Andrews et al . (2000)
Comibnation of AD and psychotherapy	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000)
Comibnation of AD and psychotherapy	Disability	−31%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000)
Proactive care	Remission	38%	Amtriptyline/Fluoxetine, cognitive therapy	de Maat et al . (2007) ; Andrews et al . (2000) ; Geddes et al . (2003)
	Disability	−31%
	Incidence	−35%
Schizophrenia
Older antipsychotics	Disability	−13%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Leutch et al . (1999)
Newer antipsychotics	Disability	−14%	Risperidone 4 mg daily	Leutch et al . (1999)
Older antipsychotics + psychosocial treatment	Disability	−23%	Chlorpromazine 100 mg daily/Fluphenazine deconate 25 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Newer antipsychotics + psychosocial treatment	Disability	−24%	Risperidone 4 mg daily, supportive psychosocial treatment	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with older antipsychotics	Disability	−24%	Chlorpromazine 300 mg daily/Fluphenazine deconate 25 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Case-management with newer antipsychotics	Disability	−25%	Risperidone 4 mg daily	Mojtabai et al . (1998) ; Leutch et al . (1999)
Bipolar disorder
Older mood stabilizer	Disability	−70%	Lithium Carbonate	Goodwin et al. (1990) ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Older mood stabilizer	Case-fatality	−65%	Lithium Carbonate
Newer mood stabilizer	Disability	−65%	Sodium Valproate	Goodwin et al . (1990) ; Bowden et al 1994 ; Angst et al . (2000) ; Bowden et al . (2000) ; Tondo et al . (2001)
Newer mood stabilizer	Case-fatality	−65%	Sodium Valproate
Older Mood Stabilizer + psychosocial	Disability	−70%	Lithium Carbonate, supportive psychososial treatment	Goodwin et al . (1990) ; Angst et al. (2000) ; Bowden et al . (2000) ; Tondo et al . (2001) ; Lam et al. (2009)
Older Mood Stabilizer + psychosocial	Case-fatality	−65%	Lithium Carbonate, supportive psychososial treatment
Newer mood stabilizer + psychosocial	Disability	−65%	Sodium Valproate, supportive psychosocial treatment	Goodwin et al. (1990) ; Bowden et al . (1994 , 2000) ; Angst et al . (2000) ; Tondo et al . (2001) ; Lam et al (2009)
Newer mood stabilizer + psychosocial	Case-fatality	−65%	Sodium Valproate, supportive psychosocial treatment
Epilepsy
Older antiepileptic	Remission	60%	Phenobarbital 100 mg daily	Annegers et al . (1979) ; Goodridge, et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Older antiepileptic	Disability	−43%	Phenobarbital 100 mg daily
Newer antiepileptic	Remission	60%	Carbamazepine 600 mg daily	Annegers et al . (1979) ; Goodridge et al . (1983) ; Placenica et al . (1994) ; Cockerell et al . (1995) , Tudur Smith et al . (2009)
Newer antiepileptic	Disability	−43 %	Carbamazepine 600 mg daily

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