Table 3. Open in new tab Linear Multiple...

Predictor

95% CI

R²

∆Fasting glucose

ΔFMI

0.20

(0.01, 0.38)

0.042

0.09

253

ΔFFMI

0.05

(−0.35, 0.45)

0.816

ΔVO₂max/FFM

−0.02

(−0.18, 0.14)

0.820

∆HOMA-IR

ΔFMI

0.59

(0.22, 0.96)

0.002

0.28

229

ΔFFMI

−0.13

(−0.42, 0.17)

0.405

ΔVO₂max/FFM

−0.16

(−0.33, 0.02)

0.084

∆BIGTT-SI

ΔFMI

−0.68

(−0.87, −0.49)

<0.001

0.47

224

ΔFFMI

0.05

(−0.13, 0.24)

0.578

ΔVO₂max/FFM

0.17

(−0.01, 0.36)

0.068

∆BIGTT-AIR

ΔFMI

0.48

(0.18, 0.77)

0.001

0.25

224

ΔFFMI

0.01

(−0.15, 0.17)

0.947

ΔVO₂max/FFM

−0.08

(−0.21, 0.04)

0.196

∆Metabolic syndrome score

ΔFMI

0.55

(0.40, 0.70)

<0.001

0.39

215

ΔFFMI

0.08

(−0.08, 0.24)

0.333

ΔVO₂max/FFM

−0.09

(−0.19, 0.01)

0.083

∆Waist-to-height ratio

ΔFMI

0.79

(0.68, 0.89)

<0.001

0.85

255

ΔFFMI

0.19

(0.12, 0.26)

<0.001

ΔVO₂max/FFM

−0.03

(−0.12, 0.06)

0.458

∆Systolic blood pressure

ΔFMI

0.36

(0.15, 0.57)

0.001

0.13

231

ΔFFMI

−0.04

(−0.23, 0.16)

0.718

ΔVO₂max/FFM

0.04

(−0.10, 0.17)

0.608

∆Diastolic blood pressure

ΔFMI

0.40

(0.20, 0.59)

<0.001

0.13

231

ΔFFMI

−0.07

(−0.34, 0.20)

0.604

ΔVO₂max/FFM

0.04

(−0.10, 0.19)

0.554

∆LDL

ΔFMI

0.47

(0.28, 0.67)

<0.001

0.16

243

ΔFFMI

−0.18

(−0.40, 0.04)

0.103

ΔVO₂max/FFM

−0.10

(−0.23, 0.03)

0.119

∆HDL

ΔFMI

−0.23

(−0.60, 0.13)

0.205

0.14

249

ΔFFMI

−0.12

(−0.30, 0.06)

0.197

ΔVO₂max/FFM

0.13

(0.03, 0.24)

0.016

∆Triglycerides

ΔFMI

0.30

(−0.03, 0.63)

0.077

0.11

245

ΔFFMI

0.02

(−0.14, 0.18)

0.834

ΔVO₂max/FFM

−0.04

(−0.23, 0.16)

0.718

∆Visceral fat volume

ΔFMI

0.98

(0.86, 1.09)

<0.001

0.85

41^a

ΔFFMI

−0.13

(−0.27, 0.04)

0.439

ΔVO₂max/FFM

−0.05

(−0.21, 0.13)

0.764

∆Liver fat %

ΔFMI

0.77

(0.52, 0.98)

<0.001

0.58

41^a

ΔFFMI

−0.11

(−0.35, 0.17)

0.504

ΔVO₂max/FFM

−0.16

(−0.41, 0.12)

0.335

Table 3.

Open in new tab

Linear Multiple Regressions of MZ Intrapair Differences (Δ) in Metabolic Health Variables by Intrapair Differences in FMI, FFMI, and VO₂max/FFM

	Predictor	β	95% CI	P	R²	N
∆Fasting glucose	ΔFMI	0.20	(0.01, 0.38)	0.042	0.09	253
	ΔFFMI	0.05	(−0.35, 0.45)	0.816
	ΔVO₂max/FFM	−0.02	(−0.18, 0.14)	0.820
∆HOMA-IR	ΔFMI	0.59	(0.22, 0.96)	0.002	0.28	229
	ΔFFMI	−0.13	(−0.42, 0.17)	0.405
	ΔVO₂max/FFM	−0.16	(−0.33, 0.02)	0.084
∆BIGTT-SI	ΔFMI	−0.68	(−0.87, −0.49)	<0.001	0.47	224
	ΔFFMI	0.05	(−0.13, 0.24)	0.578
	ΔVO₂max/FFM	0.17	(−0.01, 0.36)	0.068
∆BIGTT-AIR	ΔFMI	0.48	(0.18, 0.77)	0.001	0.25	224
	ΔFFMI	0.01	(−0.15, 0.17)	0.947
	ΔVO₂max/FFM	−0.08	(−0.21, 0.04)	0.196
∆Metabolic syndrome score	ΔFMI	0.55	(0.40, 0.70)	<0.001	0.39	215
	ΔFFMI	0.08	(−0.08, 0.24)	0.333
	ΔVO₂max/FFM	−0.09	(−0.19, 0.01)	0.083
∆Waist-to-height ratio	ΔFMI	0.79	(0.68, 0.89)	<0.001	0.85	255
	ΔFFMI	0.19	(0.12, 0.26)	<0.001
	ΔVO₂max/FFM	−0.03	(−0.12, 0.06)	0.458
∆Systolic blood pressure	ΔFMI	0.36	(0.15, 0.57)	0.001	0.13	231
	ΔFFMI	−0.04	(−0.23, 0.16)	0.718
	ΔVO₂max/FFM	0.04	(−0.10, 0.17)	0.608
∆Diastolic blood pressure	ΔFMI	0.40	(0.20, 0.59)	<0.001	0.13	231
	ΔFFMI	−0.07	(−0.34, 0.20)	0.604
	ΔVO₂max/FFM	0.04	(−0.10, 0.19)	0.554
∆LDL	ΔFMI	0.47	(0.28, 0.67)	<0.001	0.16	243
	ΔFFMI	−0.18	(−0.40, 0.04)	0.103
	ΔVO₂max/FFM	−0.10	(−0.23, 0.03)	0.119
∆HDL	ΔFMI	−0.23	(−0.60, 0.13)	0.205	0.14	249
	ΔFFMI	−0.12	(−0.30, 0.06)	0.197
	ΔVO₂max/FFM	0.13	(0.03, 0.24)	0.016
∆Triglycerides	ΔFMI	0.30	(−0.03, 0.63)	0.077	0.11	245
	ΔFFMI	0.02	(−0.14, 0.18)	0.834
	ΔVO₂max/FFM	−0.04	(−0.23, 0.16)	0.718
∆Visceral fat volume	ΔFMI	0.98	(0.86, 1.09)	<0.001	0.85	41^a
	ΔFFMI	−0.13	(−0.27, 0.04)	0.439
	ΔVO₂max/FFM	−0.05	(−0.21, 0.13)	0.764
∆Liver fat %	ΔFMI	0.77	(0.52, 0.98)	<0.001	0.58	41^a
	ΔFFMI	−0.11	(−0.35, 0.17)	0.504
	ΔVO₂max/FFM	−0.16	(−0.41, 0.12)	0.335

	Predictor	β	95% CI	P	R²	N
∆Fasting glucose	ΔFMI	0.20	(0.01, 0.38)	0.042	0.09	253
	ΔFFMI	0.05	(−0.35, 0.45)	0.816
	ΔVO₂max/FFM	−0.02	(−0.18, 0.14)	0.820
∆HOMA-IR	ΔFMI	0.59	(0.22, 0.96)	0.002	0.28	229
	ΔFFMI	−0.13	(−0.42, 0.17)	0.405
	ΔVO₂max/FFM	−0.16	(−0.33, 0.02)	0.084
∆BIGTT-SI	ΔFMI	−0.68	(−0.87, −0.49)	<0.001	0.47	224
	ΔFFMI	0.05	(−0.13, 0.24)	0.578
	ΔVO₂max/FFM	0.17	(−0.01, 0.36)	0.068
∆BIGTT-AIR	ΔFMI	0.48	(0.18, 0.77)	0.001	0.25	224
	ΔFFMI	0.01	(−0.15, 0.17)	0.947
	ΔVO₂max/FFM	−0.08	(−0.21, 0.04)	0.196
∆Metabolic syndrome score	ΔFMI	0.55	(0.40, 0.70)	<0.001	0.39	215
	ΔFFMI	0.08	(−0.08, 0.24)	0.333
	ΔVO₂max/FFM	−0.09	(−0.19, 0.01)	0.083
∆Waist-to-height ratio	ΔFMI	0.79	(0.68, 0.89)	<0.001	0.85	255
	ΔFFMI	0.19	(0.12, 0.26)	<0.001
	ΔVO₂max/FFM	−0.03	(−0.12, 0.06)	0.458
∆Systolic blood pressure	ΔFMI	0.36	(0.15, 0.57)	0.001	0.13	231
	ΔFFMI	−0.04	(−0.23, 0.16)	0.718
	ΔVO₂max/FFM	0.04	(−0.10, 0.17)	0.608
∆Diastolic blood pressure	ΔFMI	0.40	(0.20, 0.59)	<0.001	0.13	231
	ΔFFMI	−0.07	(−0.34, 0.20)	0.604
	ΔVO₂max/FFM	0.04	(−0.10, 0.19)	0.554
∆LDL	ΔFMI	0.47	(0.28, 0.67)	<0.001	0.16	243
	ΔFFMI	−0.18	(−0.40, 0.04)	0.103
	ΔVO₂max/FFM	−0.10	(−0.23, 0.03)	0.119
∆HDL	ΔFMI	−0.23	(−0.60, 0.13)	0.205	0.14	249
	ΔFFMI	−0.12	(−0.30, 0.06)	0.197
	ΔVO₂max/FFM	0.13	(0.03, 0.24)	0.016
∆Triglycerides	ΔFMI	0.30	(−0.03, 0.63)	0.077	0.11	245
	ΔFFMI	0.02	(−0.14, 0.18)	0.834
	ΔVO₂max/FFM	−0.04	(−0.23, 0.16)	0.718
∆Visceral fat volume	ΔFMI	0.98	(0.86, 1.09)	<0.001	0.85	41^a
	ΔFFMI	−0.13	(−0.27, 0.04)	0.439
	ΔVO₂max/FFM	−0.05	(−0.21, 0.13)	0.764
∆Liver fat %	ΔFMI	0.77	(0.52, 0.98)	<0.001	0.58	41^a
	ΔFFMI	−0.11	(−0.35, 0.17)	0.504
	ΔVO₂max/FFM	−0.16	(−0.41, 0.12)	0.335

Abbreviation: CI, confidence interval.

Subjects only from TwinFat. β denotes standardized regression coefficients, which correspond to how many standard deviations the outcome variable will change for an increase in the predictor of 1 standard deviation.

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