Table 3 shows the maximum ICDSC score...

Table 3 shows the maximum ICDSC score during the data collection period and recovery index. ICDSC scores of ≥4 points were found in no patients (0%) in the Ramelteon group and in 5 (9%) in the control group, whereas ICDSC scores of 0 points occurred in 21 (88%) and 49 (85%) patients in the respective groups. There was a trend that did not reach statistical significance for a lower incidence of ICDSC events in the Ramelteon group (recovery index: 0.25 ± 0.74 vs 1.58 ± 4.93, P = 0.061). A pre-delirious state in the Ramelteon group occurred only on Day 0, whereas 8 days were required for complete recovery in the control group (Fig. 2). The index intensity was 0 on Day 1 in the Ramelteon group, but did not reach a peak until Day 5 in the control group (Fig. 3).

Table 3:

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Effects of Ramelteon administration after surgery

Maximum ICDSC score	Ramelteon group (n = 24)	Control group (n = 58)	P-value
≥4	0 (0%)	5 (9%)	0.328
3	1 (4%)	0 (0%)
2	1 (4%)	0 (0%)
1	1 (4%)	4 (7%)
0	21 (88%)	49 (85%)
Recovery index^a	0.25 ± 0.74	1.58 ± 4.93	0.061

Maximum ICDSC score	Ramelteon group (n = 24)	Control group (n = 58)	P-value
≥4	0 (0%)	5 (9%)	0.328
3	1 (4%)	0 (0%)
2	1 (4%)	0 (0%)
1	1 (4%)	4 (7%)
0	21 (88%)	49 (85%)
Recovery index^a	0.25 ± 0.74	1.58 ± 4.93	0.061

ICDSC: Intensive Care Delirium Screening Checklist.

^aTotal of ICDSC scores divided by the number of patients in each group.

Table 3:

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Effects of Ramelteon administration after surgery

Maximum ICDSC score	Ramelteon group (n = 24)	Control group (n = 58)	P-value
≥4	0 (0%)	5 (9%)	0.328
3	1 (4%)	0 (0%)
2	1 (4%)	0 (0%)
1	1 (4%)	4 (7%)
0	21 (88%)	49 (85%)
Recovery index^a	0.25 ± 0.74	1.58 ± 4.93	0.061

Maximum ICDSC score	Ramelteon group (n = 24)	Control group (n = 58)	P-value
≥4	0 (0%)	5 (9%)	0.328
3	1 (4%)	0 (0%)
2	1 (4%)	0 (0%)
1	1 (4%)	4 (7%)
0	21 (88%)	49 (85%)
Recovery index^a	0.25 ± 0.74	1.58 ± 4.93	0.061

ICDSC: Intensive Care Delirium Screening Checklist.

^aTotal of ICDSC scores divided by the number of patients in each group.

Figure 2:

The recovery index (average number of ICDSC events) was calculated as the total of scores on the ICDSC divided by the number of patients in each group. The recovery index in the Ramelteon group was lower than that in the control group (P = 0.061). SE: standard error; ICDSC: Intensive Care Delirium Screening Checklist.

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Figure 3:

The intensity index was calculated as the total scores for ICDSC events divided by the total number of scored patients. ICDSC: Intensive Care Delirium Screening Checklist.

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