Table 1. Open in new tab Clinical...

OB-PCOS^# n = 18

OB-C n = 10

NW-PCOS n = 11

NW-C n = 11

Age

28.2 ± 4.9

33.5 ± 3.4

28.4 ± 5.5

27.2 ± 5.9

BMI (kg/m²)

37.4 ± 5.4

34.0 ± 5.1

21.9 ± 1.8

21.7 ± 1.8

Endometrial thickness (mm)

5.6 ± 2.2^a

5.2 ± 1.3^a

3.6 ± 2.1^b

3.4 ± 1.5^b

Endocrinological variables

LH (IU/I)

4.6 ± 1.6^a

4.9 ± 2.0^a,^b

8.6 ± 3.1^b

4.7 ± 1.1^a

FSH (IU/I)

5.1 ± 1.1^a

7.3 ± 2.9^b

6.9 ± 2.1^b

6.7 ± 2.4^b

Total testosterone (nmol/liter)

1.3 ± 0.6^a

0.7 ± 0.2^b

1.2 ± 0.3^a,^b

1.0 ± 0.3^a,^b

SHBG (nmol/liter)

27.4 ± 11.3^a

41.9 ± 18.6^b

63.5 ± 25.7^b

68.4 ± 22.6^b

Free testosterone (pmol/liter)

31.4 ± 18.3^a

12.4 ± 5.1^b,^c

18.1 ± 5.5^a,^b

12.8 ± 3.7^c

Estradiol (pmol/liter)

148 ± 66

171 ± 70

108 ± 31

134 ± 70

Insulin (mIU/liter)

75.6 ± 81.2^a

31.5 ± 15.6^a,^b

17.8 ± 6.9^b

22.9 ± 14.6^b

Relative mRNA expression

ERα

1.0 (0.7–1.3)^a

2.1 (1.6–2.4)^b

1.6 (1.2–1.6)^a,^c

1.5 (1.3–1.8)^b,^c

ERβ

0.3 (0.2–0.3)^a,^b

0.3 (0.2–0.4)^b

0.1 (0.1–0.2)^c

0.2 (0.1–0.3)^a,^b,^c

ERα/ERβ ratio

4.3 (2.9–5.2)^a

7.5 (4.7–8.5)^b

10.1 (7.6–11.5)^b

6.9 (5.8–12.5)^b

ERα36

0.5 (0.4–0.7)^a,^c

1.8 (1.0–2.9)^b

0.8 (0.5–0.9)^a,^b,^c

0.8 (0.6–1.2)^c

GPER

0.08 (0.04–0.1)

0.06 (0.05–0.09)

0.04 (0.03–0.07)

0.06 (0.03–0.1)

GPER/ERα36 ratio

0.1 (0.05–0.3)^a

0.04 (0.01–0.08)^b

0.08 (0.05–0.1)^a,^b

0.07 (0.06–0.1)^a,^b

1.4 (0.9–1.9)

1.7 (0.6–3.0)

1.8 (1.6–2.1)

1.6 (1.1–2.2)

Table 1.

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Clinical Characteristics, Endocrinological Variables, and Relative mRNA Levels of ERs and the AR on Cycle Days 6–8 in OB-PCOS, OB-C, NW-PCOS, and NW-C Groups

	OB-PCOS^# n = 18	OB-C n = 10	NW-PCOS n = 11	NW-C n = 11
Age	28.2 ± 4.9	33.5 ± 3.4	28.4 ± 5.5	27.2 ± 5.9
BMI (kg/m²)	37.4 ± 5.4	34.0 ± 5.1	21.9 ± 1.8	21.7 ± 1.8
Endometrial thickness (mm)	5.6 ± 2.2^a	5.2 ± 1.3^a	3.6 ± 2.1^b	3.4 ± 1.5^b
Endocrinological variables
LH (IU/I)	4.6 ± 1.6^a	4.9 ± 2.0^a,^b	8.6 ± 3.1^b	4.7 ± 1.1^a
FSH (IU/I)	5.1 ± 1.1^a	7.3 ± 2.9^b	6.9 ± 2.1^b	6.7 ± 2.4^b
Total testosterone (nmol/liter)	1.3 ± 0.6^a	0.7 ± 0.2^b	1.2 ± 0.3^a,^b	1.0 ± 0.3^a,^b
SHBG (nmol/liter)	27.4 ± 11.3^a	41.9 ± 18.6^b	63.5 ± 25.7^b	68.4 ± 22.6^b
Free testosterone (pmol/liter)	31.4 ± 18.3^a	12.4 ± 5.1^b,^c	18.1 ± 5.5^a,^b	12.8 ± 3.7^c
Estradiol (pmol/liter)	148 ± 66	171 ± 70	108 ± 31	134 ± 70
Insulin (mIU/liter)	75.6 ± 81.2^a	31.5 ± 15.6^a,^b	17.8 ± 6.9^b	22.9 ± 14.6^b
Relative mRNA expression
ERα	1.0 (0.7–1.3)^a	2.1 (1.6–2.4)^b	1.6 (1.2–1.6)^a,^c	1.5 (1.3–1.8)^b,^c
ERβ	0.3 (0.2–0.3)^a,^b	0.3 (0.2–0.4)^b	0.1 (0.1–0.2)^c	0.2 (0.1–0.3)^a,^b,^c
ERα/ERβ ratio	4.3 (2.9–5.2)^a	7.5 (4.7–8.5)^b	10.1 (7.6–11.5)^b	6.9 (5.8–12.5)^b
ERα36	0.5 (0.4–0.7)^a,^c	1.8 (1.0–2.9)^b	0.8 (0.5–0.9)^a,^b,^c	0.8 (0.6–1.2)^c
GPER	0.08 (0.04–0.1)	0.06 (0.05–0.09)	0.04 (0.03–0.07)	0.06 (0.03–0.1)
GPER/ERα36 ratio	0.1 (0.05–0.3)^a	0.04 (0.01–0.08)^b	0.08 (0.05–0.1)^a,^b	0.07 (0.06–0.1)^a,^b
AR	1.4 (0.9–1.9)	1.7 (0.6–3.0)	1.8 (1.6–2.1)	1.6 (1.1–2.2)

	OB-PCOS^# n = 18	OB-C n = 10	NW-PCOS n = 11	NW-C n = 11
Age	28.2 ± 4.9	33.5 ± 3.4	28.4 ± 5.5	27.2 ± 5.9
BMI (kg/m²)	37.4 ± 5.4	34.0 ± 5.1	21.9 ± 1.8	21.7 ± 1.8
Endometrial thickness (mm)	5.6 ± 2.2^a	5.2 ± 1.3^a	3.6 ± 2.1^b	3.4 ± 1.5^b
Endocrinological variables
LH (IU/I)	4.6 ± 1.6^a	4.9 ± 2.0^a,^b	8.6 ± 3.1^b	4.7 ± 1.1^a
FSH (IU/I)	5.1 ± 1.1^a	7.3 ± 2.9^b	6.9 ± 2.1^b	6.7 ± 2.4^b
Total testosterone (nmol/liter)	1.3 ± 0.6^a	0.7 ± 0.2^b	1.2 ± 0.3^a,^b	1.0 ± 0.3^a,^b
SHBG (nmol/liter)	27.4 ± 11.3^a	41.9 ± 18.6^b	63.5 ± 25.7^b	68.4 ± 22.6^b
Free testosterone (pmol/liter)	31.4 ± 18.3^a	12.4 ± 5.1^b,^c	18.1 ± 5.5^a,^b	12.8 ± 3.7^c
Estradiol (pmol/liter)	148 ± 66	171 ± 70	108 ± 31	134 ± 70
Insulin (mIU/liter)	75.6 ± 81.2^a	31.5 ± 15.6^a,^b	17.8 ± 6.9^b	22.9 ± 14.6^b
Relative mRNA expression
ERα	1.0 (0.7–1.3)^a	2.1 (1.6–2.4)^b	1.6 (1.2–1.6)^a,^c	1.5 (1.3–1.8)^b,^c
ERβ	0.3 (0.2–0.3)^a,^b	0.3 (0.2–0.4)^b	0.1 (0.1–0.2)^c	0.2 (0.1–0.3)^a,^b,^c
ERα/ERβ ratio	4.3 (2.9–5.2)^a	7.5 (4.7–8.5)^b	10.1 (7.6–11.5)^b	6.9 (5.8–12.5)^b
ERα36	0.5 (0.4–0.7)^a,^c	1.8 (1.0–2.9)^b	0.8 (0.5–0.9)^a,^b,^c	0.8 (0.6–1.2)^c
GPER	0.08 (0.04–0.1)	0.06 (0.05–0.09)	0.04 (0.03–0.07)	0.06 (0.03–0.1)
GPER/ERα36 ratio	0.1 (0.05–0.3)^a	0.04 (0.01–0.08)^b	0.08 (0.05–0.1)^a,^b	0.07 (0.06–0.1)^a,^b
AR	1.4 (0.9–1.9)	1.7 (0.6–3.0)	1.8 (1.6–2.1)	1.6 (1.1–2.2)

The values are presented as means ± sd or medians with quartile range (25th–75th quartiles).

Before the intervention.

^a,b,c

Values with different designations are significantly different (P < 0.05).

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