Tools/measure . | Frailty characteristics . | Frail versus non-frail cutoff value . |
---|---|---|
Gait speed | Measures ability to walk 5 m at a comfortable pace × 3, averaged | Slow: >6 s, very slow: >7–8 s, extremely slow: >>10 s |
The Katz index of activities of daily living | Measures ability to perform activities of daily living (bathing, dressing, transferring, walking, toileting, and feeding) independently | An abnormal score was defined as dependence in one or more activities of daily living |
The Mini–Cog | Measures cognition using paired three-item recall and clock-draw tasks | An abnormal cognition was defined as a Mini-Cog score ≤3 |
The Charlson index | Measures burden of disease by summing 19 categories of co-morbidities weighted on their risk of 1-year mortality | An abnormal chronic disease burden was defined as a Charlson score ≤3 |
Anaemia | Measures anaemia of chronic disease and disease burden | Anaemia was defined as haematocrit <35% |
Geriatric syndrome of falls | Measures self-reports of how many times the individual has fallen in the 6 months prior to surgery | A positive score of falls was defined as ≥ 1 fall in the 6 months prior to the operation |
CAF | Combines values from Fried + CFS + disability + balance + blood | CAF score ≤11 |
FORECAST | Measures ability to rise from a chair ×3, subjective reported weakness, stair climb, CFS, serum creatinine level | FORECAST score ≤5 |
Timed Up and Go test | Measures the time needed to stand up from a chair, walk 10 ft, return to the chair, and sit | An abnormal score was defined as ≥ 15 s |
Tools/measure . | Frailty characteristics . | Frail versus non-frail cutoff value . |
---|---|---|
Gait speed | Measures ability to walk 5 m at a comfortable pace × 3, averaged | Slow: >6 s, very slow: >7–8 s, extremely slow: >>10 s |
The Katz index of activities of daily living | Measures ability to perform activities of daily living (bathing, dressing, transferring, walking, toileting, and feeding) independently | An abnormal score was defined as dependence in one or more activities of daily living |
The Mini–Cog | Measures cognition using paired three-item recall and clock-draw tasks | An abnormal cognition was defined as a Mini-Cog score ≤3 |
The Charlson index | Measures burden of disease by summing 19 categories of co-morbidities weighted on their risk of 1-year mortality | An abnormal chronic disease burden was defined as a Charlson score ≤3 |
Anaemia | Measures anaemia of chronic disease and disease burden | Anaemia was defined as haematocrit <35% |
Geriatric syndrome of falls | Measures self-reports of how many times the individual has fallen in the 6 months prior to surgery | A positive score of falls was defined as ≥ 1 fall in the 6 months prior to the operation |
CAF | Combines values from Fried + CFS + disability + balance + blood | CAF score ≤11 |
FORECAST | Measures ability to rise from a chair ×3, subjective reported weakness, stair climb, CFS, serum creatinine level | FORECAST score ≤5 |
Timed Up and Go test | Measures the time needed to stand up from a chair, walk 10 ft, return to the chair, and sit | An abnormal score was defined as ≥ 15 s |
CAF: comprehensive assessment of frailty; CFS: Clinical Frailty Scale; FORECAST: Frailty predicts death One yeaR after Elective Cardiac Surgery Test.
Tools/measure . | Frailty characteristics . | Frail versus non-frail cutoff value . |
---|---|---|
Gait speed | Measures ability to walk 5 m at a comfortable pace × 3, averaged | Slow: >6 s, very slow: >7–8 s, extremely slow: >>10 s |
The Katz index of activities of daily living | Measures ability to perform activities of daily living (bathing, dressing, transferring, walking, toileting, and feeding) independently | An abnormal score was defined as dependence in one or more activities of daily living |
The Mini–Cog | Measures cognition using paired three-item recall and clock-draw tasks | An abnormal cognition was defined as a Mini-Cog score ≤3 |
The Charlson index | Measures burden of disease by summing 19 categories of co-morbidities weighted on their risk of 1-year mortality | An abnormal chronic disease burden was defined as a Charlson score ≤3 |
Anaemia | Measures anaemia of chronic disease and disease burden | Anaemia was defined as haematocrit <35% |
Geriatric syndrome of falls | Measures self-reports of how many times the individual has fallen in the 6 months prior to surgery | A positive score of falls was defined as ≥ 1 fall in the 6 months prior to the operation |
CAF | Combines values from Fried + CFS + disability + balance + blood | CAF score ≤11 |
FORECAST | Measures ability to rise from a chair ×3, subjective reported weakness, stair climb, CFS, serum creatinine level | FORECAST score ≤5 |
Timed Up and Go test | Measures the time needed to stand up from a chair, walk 10 ft, return to the chair, and sit | An abnormal score was defined as ≥ 15 s |
Tools/measure . | Frailty characteristics . | Frail versus non-frail cutoff value . |
---|---|---|
Gait speed | Measures ability to walk 5 m at a comfortable pace × 3, averaged | Slow: >6 s, very slow: >7–8 s, extremely slow: >>10 s |
The Katz index of activities of daily living | Measures ability to perform activities of daily living (bathing, dressing, transferring, walking, toileting, and feeding) independently | An abnormal score was defined as dependence in one or more activities of daily living |
The Mini–Cog | Measures cognition using paired three-item recall and clock-draw tasks | An abnormal cognition was defined as a Mini-Cog score ≤3 |
The Charlson index | Measures burden of disease by summing 19 categories of co-morbidities weighted on their risk of 1-year mortality | An abnormal chronic disease burden was defined as a Charlson score ≤3 |
Anaemia | Measures anaemia of chronic disease and disease burden | Anaemia was defined as haematocrit <35% |
Geriatric syndrome of falls | Measures self-reports of how many times the individual has fallen in the 6 months prior to surgery | A positive score of falls was defined as ≥ 1 fall in the 6 months prior to the operation |
CAF | Combines values from Fried + CFS + disability + balance + blood | CAF score ≤11 |
FORECAST | Measures ability to rise from a chair ×3, subjective reported weakness, stair climb, CFS, serum creatinine level | FORECAST score ≤5 |
Timed Up and Go test | Measures the time needed to stand up from a chair, walk 10 ft, return to the chair, and sit | An abnormal score was defined as ≥ 15 s |
CAF: comprehensive assessment of frailty; CFS: Clinical Frailty Scale; FORECAST: Frailty predicts death One yeaR after Elective Cardiac Surgery Test.
Source . | N . | Gender M/F . | Age mean (SD) years . | Frailty measure . | Description . | Primary study outcomes . | Main outcome . |
---|---|---|---|---|---|---|---|
Odds ratio/confidence interval . | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | CAF | 6-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.10 (95% CI: 1.06–1.20) |
1-year mortality OR: 1.10 (95% CI: 1.06–1.10) | |||||||
1-year mortality independent of age OR: 1.091 (95% CI: 1.049–1.135) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.089 (95% CI: 1.045–1.135) | |||||||
When added to known STS score, 1-year mortality OR: 1.087 (95% CI: 1.037–1.139) | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | FORECAST | 5-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.30 (95% CI: 1.20–1.50) |
1-year mortality OR: 1.30 (95% CI: 1.20–1.40) | |||||||
1-year mortality independent of age OR: 1.265 (95% CI: 1.143–1.401) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.271 (95% CI: 1.141–1.415) | |||||||
When added to known STS score, 1-year mortality OR: 1.264 (95% CI: 1.116–1.431) | |||||||
Lee et al. 2010 [8] | 3826 | 2828/998 | 65 ± 10 | Katz index of ADL/ambulation independence/dementia diagnosis | 5-domain questionnaire | In-hospital mortality and discharge to an institution | Adjusted in-hospital mortality OR: 1.80 (95% CI: 1.10–3.00) |
Adjusted reduced mid-term survival HR 1.50 (95% CI: 1.10–2.20) | |||||||
Adjusted prediction for institutional discharge OR: 6.30 (95% CI: 4.20–9.40 | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Mortality or major morbidity OR: 2.63 (95% CI: 1.17–5.90) |
When added to STS-PROM, mortality or major morbidity OR: 2.53 (95% CI: 1.15–5.52) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.28 (95% CI: 1.02–5.21) | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Nagi scale | 7 items | In-hospital mortality or major morbidity | Mortality or major morbidity OR:1.28 (95% CI: 1.06–1.54) |
When added to STS-PROM, mortality or major morbidity OR: 2.66 (95% CI: 1.18–5.96) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.17 (95% CI: 0.93–5.04) | |||||||
Afilalo et al. 2010 [10] | 131 | 87/44 | 75.8 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Adjusted mortality or major morbidity OR: 3.17 (95% CI: 1.7–2.59) |
Mortality or major morbidity after adjusting for STS risk score OR: 3.05 (95% CI: 1.23–7.54) | |||||||
Adjusted prolonged postoperative length of stay OR: 2.32 (95% CI: 0.95–5.67) | |||||||
Adjusted discharge to a healthcare facility OR: 3.19 (95% CI: 1.40–8.41) | |||||||
Robinson et al. 2013 [12] | 129 | 73 ± 6 | Katz index, Timed Up and Go test, Charlson index, Mini-Cog, albumin, anaemia, and fall | 7 different frailty tools | Complications | Increase in complications for every 1 year increase in age OR: 1.015 (95% CI: 0.943–1.092) | |
Likelihood for frail people to have a complication OR: 6.697 (95% CI: 2.565–17.483) | |||||||
Afilalo et al. 2011 [11] | 131 | 86/45 | 75.8 ± 4.4 | Fried scale, functional comorbidity, OARS instrumental ADL scales and Katz index of ADL | 5 items | Mortality and major morbidity | When adjusted for STS risk score, mortality or major morbidity OR: 3.14 (95% CI: 1.02–9.68) |
Source . | N . | Gender M/F . | Age mean (SD) years . | Frailty measure . | Description . | Primary study outcomes . | Main outcome . |
---|---|---|---|---|---|---|---|
Odds ratio/confidence interval . | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | CAF | 6-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.10 (95% CI: 1.06–1.20) |
1-year mortality OR: 1.10 (95% CI: 1.06–1.10) | |||||||
1-year mortality independent of age OR: 1.091 (95% CI: 1.049–1.135) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.089 (95% CI: 1.045–1.135) | |||||||
When added to known STS score, 1-year mortality OR: 1.087 (95% CI: 1.037–1.139) | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | FORECAST | 5-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.30 (95% CI: 1.20–1.50) |
1-year mortality OR: 1.30 (95% CI: 1.20–1.40) | |||||||
1-year mortality independent of age OR: 1.265 (95% CI: 1.143–1.401) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.271 (95% CI: 1.141–1.415) | |||||||
When added to known STS score, 1-year mortality OR: 1.264 (95% CI: 1.116–1.431) | |||||||
Lee et al. 2010 [8] | 3826 | 2828/998 | 65 ± 10 | Katz index of ADL/ambulation independence/dementia diagnosis | 5-domain questionnaire | In-hospital mortality and discharge to an institution | Adjusted in-hospital mortality OR: 1.80 (95% CI: 1.10–3.00) |
Adjusted reduced mid-term survival HR 1.50 (95% CI: 1.10–2.20) | |||||||
Adjusted prediction for institutional discharge OR: 6.30 (95% CI: 4.20–9.40 | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Mortality or major morbidity OR: 2.63 (95% CI: 1.17–5.90) |
When added to STS-PROM, mortality or major morbidity OR: 2.53 (95% CI: 1.15–5.52) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.28 (95% CI: 1.02–5.21) | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Nagi scale | 7 items | In-hospital mortality or major morbidity | Mortality or major morbidity OR:1.28 (95% CI: 1.06–1.54) |
When added to STS-PROM, mortality or major morbidity OR: 2.66 (95% CI: 1.18–5.96) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.17 (95% CI: 0.93–5.04) | |||||||
Afilalo et al. 2010 [10] | 131 | 87/44 | 75.8 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Adjusted mortality or major morbidity OR: 3.17 (95% CI: 1.7–2.59) |
Mortality or major morbidity after adjusting for STS risk score OR: 3.05 (95% CI: 1.23–7.54) | |||||||
Adjusted prolonged postoperative length of stay OR: 2.32 (95% CI: 0.95–5.67) | |||||||
Adjusted discharge to a healthcare facility OR: 3.19 (95% CI: 1.40–8.41) | |||||||
Robinson et al. 2013 [12] | 129 | 73 ± 6 | Katz index, Timed Up and Go test, Charlson index, Mini-Cog, albumin, anaemia, and fall | 7 different frailty tools | Complications | Increase in complications for every 1 year increase in age OR: 1.015 (95% CI: 0.943–1.092) | |
Likelihood for frail people to have a complication OR: 6.697 (95% CI: 2.565–17.483) | |||||||
Afilalo et al. 2011 [11] | 131 | 86/45 | 75.8 ± 4.4 | Fried scale, functional comorbidity, OARS instrumental ADL scales and Katz index of ADL | 5 items | Mortality and major morbidity | When adjusted for STS risk score, mortality or major morbidity OR: 3.14 (95% CI: 1.02–9.68) |
ADL: activity of daily living; CAF: comprehensive assessment of frailty; CI: confidence interval; FORECAST: Frailty predicts death One yeaR after Elective Cardiac Surgery test; OARS: Older American Resources and Services; OR: odds ratio; STS: Society of Thoracic Surgeons; STS-PROM: STS predicted risk of mortality.
Source . | N . | Gender M/F . | Age mean (SD) years . | Frailty measure . | Description . | Primary study outcomes . | Main outcome . |
---|---|---|---|---|---|---|---|
Odds ratio/confidence interval . | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | CAF | 6-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.10 (95% CI: 1.06–1.20) |
1-year mortality OR: 1.10 (95% CI: 1.06–1.10) | |||||||
1-year mortality independent of age OR: 1.091 (95% CI: 1.049–1.135) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.089 (95% CI: 1.045–1.135) | |||||||
When added to known STS score, 1-year mortality OR: 1.087 (95% CI: 1.037–1.139) | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | FORECAST | 5-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.30 (95% CI: 1.20–1.50) |
1-year mortality OR: 1.30 (95% CI: 1.20–1.40) | |||||||
1-year mortality independent of age OR: 1.265 (95% CI: 1.143–1.401) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.271 (95% CI: 1.141–1.415) | |||||||
When added to known STS score, 1-year mortality OR: 1.264 (95% CI: 1.116–1.431) | |||||||
Lee et al. 2010 [8] | 3826 | 2828/998 | 65 ± 10 | Katz index of ADL/ambulation independence/dementia diagnosis | 5-domain questionnaire | In-hospital mortality and discharge to an institution | Adjusted in-hospital mortality OR: 1.80 (95% CI: 1.10–3.00) |
Adjusted reduced mid-term survival HR 1.50 (95% CI: 1.10–2.20) | |||||||
Adjusted prediction for institutional discharge OR: 6.30 (95% CI: 4.20–9.40 | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Mortality or major morbidity OR: 2.63 (95% CI: 1.17–5.90) |
When added to STS-PROM, mortality or major morbidity OR: 2.53 (95% CI: 1.15–5.52) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.28 (95% CI: 1.02–5.21) | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Nagi scale | 7 items | In-hospital mortality or major morbidity | Mortality or major morbidity OR:1.28 (95% CI: 1.06–1.54) |
When added to STS-PROM, mortality or major morbidity OR: 2.66 (95% CI: 1.18–5.96) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.17 (95% CI: 0.93–5.04) | |||||||
Afilalo et al. 2010 [10] | 131 | 87/44 | 75.8 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Adjusted mortality or major morbidity OR: 3.17 (95% CI: 1.7–2.59) |
Mortality or major morbidity after adjusting for STS risk score OR: 3.05 (95% CI: 1.23–7.54) | |||||||
Adjusted prolonged postoperative length of stay OR: 2.32 (95% CI: 0.95–5.67) | |||||||
Adjusted discharge to a healthcare facility OR: 3.19 (95% CI: 1.40–8.41) | |||||||
Robinson et al. 2013 [12] | 129 | 73 ± 6 | Katz index, Timed Up and Go test, Charlson index, Mini-Cog, albumin, anaemia, and fall | 7 different frailty tools | Complications | Increase in complications for every 1 year increase in age OR: 1.015 (95% CI: 0.943–1.092) | |
Likelihood for frail people to have a complication OR: 6.697 (95% CI: 2.565–17.483) | |||||||
Afilalo et al. 2011 [11] | 131 | 86/45 | 75.8 ± 4.4 | Fried scale, functional comorbidity, OARS instrumental ADL scales and Katz index of ADL | 5 items | Mortality and major morbidity | When adjusted for STS risk score, mortality or major morbidity OR: 3.14 (95% CI: 1.02–9.68) |
Source . | N . | Gender M/F . | Age mean (SD) years . | Frailty measure . | Description . | Primary study outcomes . | Main outcome . |
---|---|---|---|---|---|---|---|
Odds ratio/confidence interval . | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | CAF | 6-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.10 (95% CI: 1.06–1.20) |
1-year mortality OR: 1.10 (95% CI: 1.06–1.10) | |||||||
1-year mortality independent of age OR: 1.091 (95% CI: 1.049–1.135) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.089 (95% CI: 1.045–1.135) | |||||||
When added to known STS score, 1-year mortality OR: 1.087 (95% CI: 1.037–1.139) | |||||||
Sundermann et al. 2014 [9] | 450 | 227/223 | 79 ± 4 | FORECAST | 5-domain questionnaire | 30-day mortality, 1-year mortality | 30-day mortality OR: 1.30 (95% CI: 1.20–1.50) |
1-year mortality OR: 1.30 (95% CI: 1.20–1.40) | |||||||
1-year mortality independent of age OR: 1.265 (95% CI: 1.143–1.401) | |||||||
When added to known EuroSCORE, 1-year mortality OR: 1.271 (95% CI: 1.141–1.415) | |||||||
When added to known STS score, 1-year mortality OR: 1.264 (95% CI: 1.116–1.431) | |||||||
Lee et al. 2010 [8] | 3826 | 2828/998 | 65 ± 10 | Katz index of ADL/ambulation independence/dementia diagnosis | 5-domain questionnaire | In-hospital mortality and discharge to an institution | Adjusted in-hospital mortality OR: 1.80 (95% CI: 1.10–3.00) |
Adjusted reduced mid-term survival HR 1.50 (95% CI: 1.10–2.20) | |||||||
Adjusted prediction for institutional discharge OR: 6.30 (95% CI: 4.20–9.40 | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Mortality or major morbidity OR: 2.63 (95% CI: 1.17–5.90) |
When added to STS-PROM, mortality or major morbidity OR: 2.53 (95% CI: 1.15–5.52) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.28 (95% CI: 1.02–5.21) | |||||||
Afilalo et al. 2012 [6] | 152 | 100/52 | 75.9 ± 4.4 | Nagi scale | 7 items | In-hospital mortality or major morbidity | Mortality or major morbidity OR:1.28 (95% CI: 1.06–1.54) |
When added to STS-PROM, mortality or major morbidity OR: 2.66 (95% CI: 1.18–5.96) | |||||||
When added to the Parsonnet score, mortality or major morbidity OR: 2.17 (95% CI: 0.93–5.04) | |||||||
Afilalo et al. 2010 [10] | 131 | 87/44 | 75.8 ± 4.4 | Gait speed | 5-m gait speed for more than 6 s | In-hospital mortality or major morbidity | Adjusted mortality or major morbidity OR: 3.17 (95% CI: 1.7–2.59) |
Mortality or major morbidity after adjusting for STS risk score OR: 3.05 (95% CI: 1.23–7.54) | |||||||
Adjusted prolonged postoperative length of stay OR: 2.32 (95% CI: 0.95–5.67) | |||||||
Adjusted discharge to a healthcare facility OR: 3.19 (95% CI: 1.40–8.41) | |||||||
Robinson et al. 2013 [12] | 129 | 73 ± 6 | Katz index, Timed Up and Go test, Charlson index, Mini-Cog, albumin, anaemia, and fall | 7 different frailty tools | Complications | Increase in complications for every 1 year increase in age OR: 1.015 (95% CI: 0.943–1.092) | |
Likelihood for frail people to have a complication OR: 6.697 (95% CI: 2.565–17.483) | |||||||
Afilalo et al. 2011 [11] | 131 | 86/45 | 75.8 ± 4.4 | Fried scale, functional comorbidity, OARS instrumental ADL scales and Katz index of ADL | 5 items | Mortality and major morbidity | When adjusted for STS risk score, mortality or major morbidity OR: 3.14 (95% CI: 1.02–9.68) |
ADL: activity of daily living; CAF: comprehensive assessment of frailty; CI: confidence interval; FORECAST: Frailty predicts death One yeaR after Elective Cardiac Surgery test; OARS: Older American Resources and Services; OR: odds ratio; STS: Society of Thoracic Surgeons; STS-PROM: STS predicted risk of mortality.
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