| Population . | rs7634898 . | rs7635012 . | rs6790260 . | rs28637341 . | rs6444284 . | rs6444285 . | rs4686483 . | rs4686484 . | rs6778720 . | rs2030520 . | rs2030519 . | rs6785284 . | rs1035765 . | rs12634152 . | Frequency . | Freq cases . | Freq controls . | OR . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meta-analysisa | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.454 | 0.4219 | 0.4857 | 0.768 | 9.41E−45 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.435 | 0.4609 | 0.4081 | 1.25 | 8.70E−32 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0477 | 0.05143 | 0.044 | 1.18 | 0.000115 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0619 | 0.06375 | 0.06003 | 1.06 | 0.111 | |
| UK | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.447 | 0.4094 | 0.4818 | 0.74 | 2.84E−38 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.438 | 0.4673 | 0.41 | 1.28 | 1.45E−25 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0465 | 0.05092 | 0.0423 | 1.22 | 0.000294 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0673 | 0.07046 | 0.06442 | 1.09 | 0.051 | |
| Italy | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.487 | 0.4556 | 0.5248 | 0.755 | 4.12E−07 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.431 | 0.4599 | 0.398 | 1.29 | 4.67E−06 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0292 | 0.03131 | 0.02677 | 1.2 | 0.262 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05051 | 0.04567 | 1.09 | 0.503 | |
| The Netherlands | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.437 | 0.4143 | 0.4595 | 0.843 | 0.00482 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.456 | 0.4796 | 0.4335 | 1.2 | 0.00277 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0575 | 0.05696 | 0.05797 | 0.945 | 0.659 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0474 | 0.04783 | 0.04646 | 1.02 | 0.879 | |
| Spain | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.488 | 0.4654 | 0.5257 | 0.783 | 0.000551 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.4 | 0.4149 | 0.3754 | 1.17 | 0.0245 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05275 | 0.04079 | 1.3 | 0.131 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0623 | 0.06605 | 0.05589 | 1.21 | 0.199 |
| Population . | rs7634898 . | rs7635012 . | rs6790260 . | rs28637341 . | rs6444284 . | rs6444285 . | rs4686483 . | rs4686484 . | rs6778720 . | rs2030520 . | rs2030519 . | rs6785284 . | rs1035765 . | rs12634152 . | Frequency . | Freq cases . | Freq controls . | OR . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meta-analysisa | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.454 | 0.4219 | 0.4857 | 0.768 | 9.41E−45 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.435 | 0.4609 | 0.4081 | 1.25 | 8.70E−32 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0477 | 0.05143 | 0.044 | 1.18 | 0.000115 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0619 | 0.06375 | 0.06003 | 1.06 | 0.111 | |
| UK | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.447 | 0.4094 | 0.4818 | 0.74 | 2.84E−38 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.438 | 0.4673 | 0.41 | 1.28 | 1.45E−25 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0465 | 0.05092 | 0.0423 | 1.22 | 0.000294 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0673 | 0.07046 | 0.06442 | 1.09 | 0.051 | |
| Italy | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.487 | 0.4556 | 0.5248 | 0.755 | 4.12E−07 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.431 | 0.4599 | 0.398 | 1.29 | 4.67E−06 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0292 | 0.03131 | 0.02677 | 1.2 | 0.262 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05051 | 0.04567 | 1.09 | 0.503 | |
| The Netherlands | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.437 | 0.4143 | 0.4595 | 0.843 | 0.00482 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.456 | 0.4796 | 0.4335 | 1.2 | 0.00277 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0575 | 0.05696 | 0.05797 | 0.945 | 0.659 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0474 | 0.04783 | 0.04646 | 1.02 | 0.879 | |
| Spain | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.488 | 0.4654 | 0.5257 | 0.783 | 0.000551 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.4 | 0.4149 | 0.3754 | 1.17 | 0.0245 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05275 | 0.04079 | 1.3 | 0.131 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0623 | 0.06605 | 0.05589 | 1.21 | 0.199 |
The SNP in bold is the top SNP from the meta-analysis. The minor alleles from each SNP are bold. The SNP that differentiate the risk to non-risk haplotype are highlighted in bold. OR are shown for minor haplotypes. P-values (P) were calculated according to a haplotype logistic regression association test.
aMeta-analysis without Indian and Polish cohorts.
| Population . | rs7634898 . | rs7635012 . | rs6790260 . | rs28637341 . | rs6444284 . | rs6444285 . | rs4686483 . | rs4686484 . | rs6778720 . | rs2030520 . | rs2030519 . | rs6785284 . | rs1035765 . | rs12634152 . | Frequency . | Freq cases . | Freq controls . | OR . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meta-analysisa | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.454 | 0.4219 | 0.4857 | 0.768 | 9.41E−45 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.435 | 0.4609 | 0.4081 | 1.25 | 8.70E−32 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0477 | 0.05143 | 0.044 | 1.18 | 0.000115 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0619 | 0.06375 | 0.06003 | 1.06 | 0.111 | |
| UK | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.447 | 0.4094 | 0.4818 | 0.74 | 2.84E−38 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.438 | 0.4673 | 0.41 | 1.28 | 1.45E−25 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0465 | 0.05092 | 0.0423 | 1.22 | 0.000294 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0673 | 0.07046 | 0.06442 | 1.09 | 0.051 | |
| Italy | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.487 | 0.4556 | 0.5248 | 0.755 | 4.12E−07 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.431 | 0.4599 | 0.398 | 1.29 | 4.67E−06 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0292 | 0.03131 | 0.02677 | 1.2 | 0.262 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05051 | 0.04567 | 1.09 | 0.503 | |
| The Netherlands | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.437 | 0.4143 | 0.4595 | 0.843 | 0.00482 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.456 | 0.4796 | 0.4335 | 1.2 | 0.00277 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0575 | 0.05696 | 0.05797 | 0.945 | 0.659 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0474 | 0.04783 | 0.04646 | 1.02 | 0.879 | |
| Spain | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.488 | 0.4654 | 0.5257 | 0.783 | 0.000551 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.4 | 0.4149 | 0.3754 | 1.17 | 0.0245 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05275 | 0.04079 | 1.3 | 0.131 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0623 | 0.06605 | 0.05589 | 1.21 | 0.199 |
| Population . | rs7634898 . | rs7635012 . | rs6790260 . | rs28637341 . | rs6444284 . | rs6444285 . | rs4686483 . | rs4686484 . | rs6778720 . | rs2030520 . | rs2030519 . | rs6785284 . | rs1035765 . | rs12634152 . | Frequency . | Freq cases . | Freq controls . | OR . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Meta-analysisa | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.454 | 0.4219 | 0.4857 | 0.768 | 9.41E−45 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.435 | 0.4609 | 0.4081 | 1.25 | 8.70E−32 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0477 | 0.05143 | 0.044 | 1.18 | 0.000115 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0619 | 0.06375 | 0.06003 | 1.06 | 0.111 | |
| UK | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.447 | 0.4094 | 0.4818 | 0.74 | 2.84E−38 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.438 | 0.4673 | 0.41 | 1.28 | 1.45E−25 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0465 | 0.05092 | 0.0423 | 1.22 | 0.000294 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0673 | 0.07046 | 0.06442 | 1.09 | 0.051 | |
| Italy | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.487 | 0.4556 | 0.5248 | 0.755 | 4.12E−07 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.431 | 0.4599 | 0.398 | 1.29 | 4.67E−06 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0292 | 0.03131 | 0.02677 | 1.2 | 0.262 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05051 | 0.04567 | 1.09 | 0.503 | |
| The Netherlands | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.437 | 0.4143 | 0.4595 | 0.843 | 0.00482 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.456 | 0.4796 | 0.4335 | 1.2 | 0.00277 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0575 | 0.05696 | 0.05797 | 0.945 | 0.659 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0474 | 0.04783 | 0.04646 | 1.02 | 0.879 | |
| Spain | C | C | G | A | T | C | T | G | G | C | G | C | A | T | 0.488 | 0.4654 | 0.5257 | 0.783 | 0.000551 |
| C | C | C | T | C | T | A | A | A | T | A | T | T | C | 0.4 | 0.4149 | 0.3754 | 1.17 | 0.0245 | |
| T | A | C | A | T | T | A | A | A | T | A | C | A | C | 0.0483 | 0.05275 | 0.04079 | 1.3 | 0.131 | |
| C | A | C | A | T | T | A | A | A | T | A | C | A | T | 0.0623 | 0.06605 | 0.05589 | 1.21 | 0.199 |
The SNP in bold is the top SNP from the meta-analysis. The minor alleles from each SNP are bold. The SNP that differentiate the risk to non-risk haplotype are highlighted in bold. OR are shown for minor haplotypes. P-values (P) were calculated according to a haplotype logistic regression association test.
aMeta-analysis without Indian and Polish cohorts.
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