Table 3
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Peak GATES gene-based associations with longitudinal change in amyloid PET burden

ChromosomeGene symbolGene nameGATES P
3IL1RAPInterleukin-1 receptor accessory protein9.45 × 10−8
20PSMA7Proteasome subunit, alpha type, 71.33 × 10−4
20LSM14BSCD6 homolog B (S. cerevisiae)1.46 × 10−4
21JAM2Junctional adhesion molecule 21.59 × 10−4
19APOC1Apolipoprotein C11.74 × 10−4
2UBR3Ubiquitin protein ligase E3 component n-recognin 3 (putative)1.75 × 10−4
19APOEApolipoprotein E2.26 × 10−4
10PNLIPRP1Pancreatic lipase-related protein 12.33 × 10−4
19TOMM40Translocase of outer mitochondrial membrane 40 homolog (yeast)3.10 × 10−4
3MIR6828MicroRNA 68283.12 × 10−4
14SNAPC1Small nuclear RNA activating complex, polypeptide 13.47 × 10−4
12BRI3BPBrain protein I3 binding protein3.82 × 10−4
20SS18L1Synovial sarcoma translocation gene on chromosome 18-like 14.09 × 10−4
3CLDN11Claudin 114.98 × 10−4
ChromosomeGene symbolGene nameGATES P
3IL1RAPInterleukin-1 receptor accessory protein9.45 × 10−8
20PSMA7Proteasome subunit, alpha type, 71.33 × 10−4
20LSM14BSCD6 homolog B (S. cerevisiae)1.46 × 10−4
21JAM2Junctional adhesion molecule 21.59 × 10−4
19APOC1Apolipoprotein C11.74 × 10−4
2UBR3Ubiquitin protein ligase E3 component n-recognin 3 (putative)1.75 × 10−4
19APOEApolipoprotein E2.26 × 10−4
10PNLIPRP1Pancreatic lipase-related protein 12.33 × 10−4
19TOMM40Translocase of outer mitochondrial membrane 40 homolog (yeast)3.10 × 10−4
3MIR6828MicroRNA 68283.12 × 10−4
14SNAPC1Small nuclear RNA activating complex, polypeptide 13.47 × 10−4
12BRI3BPBrain protein I3 binding protein3.82 × 10−4
20SS18L1Synovial sarcoma translocation gene on chromosome 18-like 14.09 × 10−4
3CLDN11Claudin 114.98 × 10−4
Table 3
Open in new tab

Peak GATES gene-based associations with longitudinal change in amyloid PET burden

ChromosomeGene symbolGene nameGATES P
3IL1RAPInterleukin-1 receptor accessory protein9.45 × 10−8
20PSMA7Proteasome subunit, alpha type, 71.33 × 10−4
20LSM14BSCD6 homolog B (S. cerevisiae)1.46 × 10−4
21JAM2Junctional adhesion molecule 21.59 × 10−4
19APOC1Apolipoprotein C11.74 × 10−4
2UBR3Ubiquitin protein ligase E3 component n-recognin 3 (putative)1.75 × 10−4
19APOEApolipoprotein E2.26 × 10−4
10PNLIPRP1Pancreatic lipase-related protein 12.33 × 10−4
19TOMM40Translocase of outer mitochondrial membrane 40 homolog (yeast)3.10 × 10−4
3MIR6828MicroRNA 68283.12 × 10−4
14SNAPC1Small nuclear RNA activating complex, polypeptide 13.47 × 10−4
12BRI3BPBrain protein I3 binding protein3.82 × 10−4
20SS18L1Synovial sarcoma translocation gene on chromosome 18-like 14.09 × 10−4
3CLDN11Claudin 114.98 × 10−4
ChromosomeGene symbolGene nameGATES P
3IL1RAPInterleukin-1 receptor accessory protein9.45 × 10−8
20PSMA7Proteasome subunit, alpha type, 71.33 × 10−4
20LSM14BSCD6 homolog B (S. cerevisiae)1.46 × 10−4
21JAM2Junctional adhesion molecule 21.59 × 10−4
19APOC1Apolipoprotein C11.74 × 10−4
2UBR3Ubiquitin protein ligase E3 component n-recognin 3 (putative)1.75 × 10−4
19APOEApolipoprotein E2.26 × 10−4
10PNLIPRP1Pancreatic lipase-related protein 12.33 × 10−4
19TOMM40Translocase of outer mitochondrial membrane 40 homolog (yeast)3.10 × 10−4
3MIR6828MicroRNA 68283.12 × 10−4
14SNAPC1Small nuclear RNA activating complex, polypeptide 13.47 × 10−4
12BRI3BPBrain protein I3 binding protein3.82 × 10−4
20SS18L1Synovial sarcoma translocation gene on chromosome 18-like 14.09 × 10−4
3CLDN11Claudin 114.98 × 10−4
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