| ILR findings in Phase 1 . | ISSUE classification . | Therapy . | Phase 2 . |
|---|---|---|---|
| ECG documentation of non-syncopal (asymptomatic or pre-syncopal) asystolic events of ≥ 6 s | Type 1 | Pacemaker | RCT |
| Syncope, asystolic | Type 1 | Pacemaker | RCT |
| Syncope, bradycardia | Type 2 | CPM | PC 2 study |
| Syncope, slight or no rhythm variations | Type 3 | CPM | PC 2 study |
| Syncope, sinus tachycardia | Type 4A | CPM | PC 2 study |
| Syncope, tachycardia | Type 4B,C,D | Individual | Noa |
| ILR findings in Phase 1 . | ISSUE classification . | Therapy . | Phase 2 . |
|---|---|---|---|
| ECG documentation of non-syncopal (asymptomatic or pre-syncopal) asystolic events of ≥ 6 s | Type 1 | Pacemaker | RCT |
| Syncope, asystolic | Type 1 | Pacemaker | RCT |
| Syncope, bradycardia | Type 2 | CPM | PC 2 study |
| Syncope, slight or no rhythm variations | Type 3 | CPM | PC 2 study |
| Syncope, sinus tachycardia | Type 4A | CPM | PC 2 study |
| Syncope, tachycardia | Type 4B,C,D | Individual | Noa |
RCT, randomized controlled trial; CPM, counterpressure manoeuvres.
aUsual clinical management outside the trial.
| ILR findings in Phase 1 . | ISSUE classification . | Therapy . | Phase 2 . |
|---|---|---|---|
| ECG documentation of non-syncopal (asymptomatic or pre-syncopal) asystolic events of ≥ 6 s | Type 1 | Pacemaker | RCT |
| Syncope, asystolic | Type 1 | Pacemaker | RCT |
| Syncope, bradycardia | Type 2 | CPM | PC 2 study |
| Syncope, slight or no rhythm variations | Type 3 | CPM | PC 2 study |
| Syncope, sinus tachycardia | Type 4A | CPM | PC 2 study |
| Syncope, tachycardia | Type 4B,C,D | Individual | Noa |
| ILR findings in Phase 1 . | ISSUE classification . | Therapy . | Phase 2 . |
|---|---|---|---|
| ECG documentation of non-syncopal (asymptomatic or pre-syncopal) asystolic events of ≥ 6 s | Type 1 | Pacemaker | RCT |
| Syncope, asystolic | Type 1 | Pacemaker | RCT |
| Syncope, bradycardia | Type 2 | CPM | PC 2 study |
| Syncope, slight or no rhythm variations | Type 3 | CPM | PC 2 study |
| Syncope, sinus tachycardia | Type 4A | CPM | PC 2 study |
| Syncope, tachycardia | Type 4B,C,D | Individual | Noa |
RCT, randomized controlled trial; CPM, counterpressure manoeuvres.
aUsual clinical management outside the trial.
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