Table 2 Open in new tab TFs Controlling...

	d_R/d_S	d_C/d_S
Charge	0.0471 ± 0.006	0.0325 ± 0.003*	0.1084 ± 0.008	0.0586 ± 0.005***
Polarity	0.0793 ± 0.007	0.0361 ± 0.004***	0.0849 ± 0.007	0.0554 ± 0.004***
Volume & polarity	0.0587 ± 0.005	0.0360 ± 0.003***	0.1347 ± 0.011	0.0748 ± 0.006***
Charge &aromatic	0.0498 ± 0.005	0.0369 ± 0.003*	0.1209 ± 0.010	0.0619 ± 0.005***
Charge & polarity	0.0635 ± 0.006	0.0359 ± 0.003***	0.1193 ± 0.009	0.0677 ± 0.005***

	d_R/d_S	d_C/d_S
Charge	0.0471 ± 0.006	0.0325 ± 0.003*	0.1084 ± 0.008	0.0586 ± 0.005***
Polarity	0.0793 ± 0.007	0.0361 ± 0.004***	0.0849 ± 0.007	0.0554 ± 0.004***
Volume & polarity	0.0587 ± 0.005	0.0360 ± 0.003***	0.1347 ± 0.011	0.0748 ± 0.006***
Charge &aromatic	0.0498 ± 0.005	0.0369 ± 0.003*	0.1209 ± 0.010	0.0619 ± 0.005***
Charge & polarity	0.0635 ± 0.006	0.0359 ± 0.003***	0.1193 ± 0.009	0.0677 ± 0.005***

Table 2

TFs Controlling Chemosensory Neuron Differentiation Exhibit Higher Levels of Radical Nonsynonymous/Synonymous (d_R/d_S) and Conservative Nonsynonymous/Synonymous (d_C/d_S) Rate Ratios Than Structural Chemosensory Genes

	d_R/d_S		d_C/d_S
Chemical Classification	TF	Structural	TF	Structural
Charge	0.0471 ± 0.006	0.0325 ± 0.003*	0.1084 ± 0.008	0.0586 ± 0.005***
Polarity	0.0793 ± 0.007	0.0361 ± 0.004***	0.0849 ± 0.007	0.0554 ± 0.004***
Volume & polarity	0.0587 ± 0.005	0.0360 ± 0.003***	0.1347 ± 0.011	0.0748 ± 0.006***
Charge &aromatic	0.0498 ± 0.005	0.0369 ± 0.003*	0.1209 ± 0.010	0.0619 ± 0.005***
Charge & polarity	0.0635 ± 0.006	0.0359 ± 0.003***	0.1193 ± 0.009	0.0677 ± 0.005***

	d_R/d_S		d_C/d_S
Chemical Classification	TF	Structural	TF	Structural
Charge	0.0471 ± 0.006	0.0325 ± 0.003*	0.1084 ± 0.008	0.0586 ± 0.005***
Polarity	0.0793 ± 0.007	0.0361 ± 0.004***	0.0849 ± 0.007	0.0554 ± 0.004***
Volume & polarity	0.0587 ± 0.005	0.0360 ± 0.003***	0.1347 ± 0.011	0.0748 ± 0.006***
Charge &aromatic	0.0498 ± 0.005	0.0369 ± 0.003*	0.1209 ± 0.010	0.0619 ± 0.005***
Charge & polarity	0.0635 ± 0.006	0.0359 ± 0.003***	0.1193 ± 0.009	0.0677 ± 0.005***

NOTE.—Mean ± 1 standard error. Significance is obtained from a nonparametric Wilcoxon two-sample test: *P < 0.05, **P < 0.01, and ***P < 0.001. The list of TFs used in this analysis is reported in supplementary table 3, Supplementary Material online.

The radical and conservative amino acid changes are based on five amino acid chemical classifications. Caenorhabditis remanei and Caenorhabditis briggsae were used to compute divergence.

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