| Biomarker . | Assay used (laboratory) . |
|---|---|
| β2-Microglobulin (B2M, µg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Fibroblast growth factor 23 C-terminal (FGF23 C-Term, RU/mL) | ELISA (eBioscience, San Diego, CA, USA) |
| Granulocyte macrophage-colony stimulating factor (GM-CSF, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interferon gamma (IFN gamma, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-10 (IL-10, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-18 (IL18, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 (IL-2, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 receptor alpha (IL2.RA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-3 (IL-3, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-4 (IL-4, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-5 (IL-5, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-6 (IL-6, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-7 ( IL-7, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-8 ( IL8, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Latency-associated peptide transforming growth factor β1 (LAP.TGFB1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Monocyte chemotactic protein 1 (MCP1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteoprotegerin (OPG, pM) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Cystatin C (ng/mL) | RBM Human Custom MAP Core I, HMPC62, (Myriad RBM, Austin, TX, USA) |
| Eotaxin-2 (pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteopontin (OPN, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Major histocompatibility complex Class I-related chain A (MICA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 alpha (MIP1ALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 beta (MIP1BETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Matrix metalloproteinase-2 (MMP2, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Neutrophil gelatinase-associated lipocalin (NGAL, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tissue inhibitor of metalloproteinases 1 (TIMP1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor receptor Type I (TNFR1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor alpha (TNFALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor beta (TNFBETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Biomarker . | Assay used (laboratory) . |
|---|---|
| β2-Microglobulin (B2M, µg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Fibroblast growth factor 23 C-terminal (FGF23 C-Term, RU/mL) | ELISA (eBioscience, San Diego, CA, USA) |
| Granulocyte macrophage-colony stimulating factor (GM-CSF, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interferon gamma (IFN gamma, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-10 (IL-10, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-18 (IL18, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 (IL-2, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 receptor alpha (IL2.RA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-3 (IL-3, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-4 (IL-4, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-5 (IL-5, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-6 (IL-6, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-7 ( IL-7, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-8 ( IL8, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Latency-associated peptide transforming growth factor β1 (LAP.TGFB1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Monocyte chemotactic protein 1 (MCP1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteoprotegerin (OPG, pM) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Cystatin C (ng/mL) | RBM Human Custom MAP Core I, HMPC62, (Myriad RBM, Austin, TX, USA) |
| Eotaxin-2 (pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteopontin (OPN, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Major histocompatibility complex Class I-related chain A (MICA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 alpha (MIP1ALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 beta (MIP1BETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Matrix metalloproteinase-2 (MMP2, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Neutrophil gelatinase-associated lipocalin (NGAL, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tissue inhibitor of metalloproteinases 1 (TIMP1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor receptor Type I (TNFR1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor alpha (TNFALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor beta (TNFBETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
Shaded rows indicate biomarkers that were not included in the analysis because of high variability or low levels.
| Biomarker . | Assay used (laboratory) . |
|---|---|
| β2-Microglobulin (B2M, µg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Fibroblast growth factor 23 C-terminal (FGF23 C-Term, RU/mL) | ELISA (eBioscience, San Diego, CA, USA) |
| Granulocyte macrophage-colony stimulating factor (GM-CSF, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interferon gamma (IFN gamma, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-10 (IL-10, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-18 (IL18, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 (IL-2, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 receptor alpha (IL2.RA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-3 (IL-3, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-4 (IL-4, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-5 (IL-5, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-6 (IL-6, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-7 ( IL-7, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-8 ( IL8, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Latency-associated peptide transforming growth factor β1 (LAP.TGFB1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Monocyte chemotactic protein 1 (MCP1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteoprotegerin (OPG, pM) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Cystatin C (ng/mL) | RBM Human Custom MAP Core I, HMPC62, (Myriad RBM, Austin, TX, USA) |
| Eotaxin-2 (pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteopontin (OPN, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Major histocompatibility complex Class I-related chain A (MICA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 alpha (MIP1ALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 beta (MIP1BETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Matrix metalloproteinase-2 (MMP2, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Neutrophil gelatinase-associated lipocalin (NGAL, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tissue inhibitor of metalloproteinases 1 (TIMP1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor receptor Type I (TNFR1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor alpha (TNFALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor beta (TNFBETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Biomarker . | Assay used (laboratory) . |
|---|---|
| β2-Microglobulin (B2M, µg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Fibroblast growth factor 23 C-terminal (FGF23 C-Term, RU/mL) | ELISA (eBioscience, San Diego, CA, USA) |
| Granulocyte macrophage-colony stimulating factor (GM-CSF, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interferon gamma (IFN gamma, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-10 (IL-10, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-18 (IL18, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 (IL-2, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-2 receptor alpha (IL2.RA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-3 (IL-3, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-4 (IL-4, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-5 (IL-5, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-6 (IL-6, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-7 ( IL-7, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Interleukin-8 ( IL8, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Latency-associated peptide transforming growth factor β1 (LAP.TGFB1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Monocyte chemotactic protein 1 (MCP1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteoprotegerin (OPG, pM) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Cystatin C (ng/mL) | RBM Human Custom MAP Core I, HMPC62, (Myriad RBM, Austin, TX, USA) |
| Eotaxin-2 (pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Osteopontin (OPN, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Major histocompatibility complex Class I-related chain A (MICA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 alpha (MIP1ALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Macrophage inflammatory protein 1 beta (MIP1BETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Matrix metalloproteinase-2 (MMP2, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Neutrophil gelatinase-associated lipocalin (NGAL, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tissue inhibitor of metalloproteinases 1 (TIMP1, ng/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor receptor Type I (TNFR1, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor alpha (TNFALPHA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
| Tumour necrosis factor beta (TNFBETA, pg/mL) | RBM Human Custom MAP Core I, HMPC62, HMPC37 (Myriad RBM, Austin, TX, USA) |
Shaded rows indicate biomarkers that were not included in the analysis because of high variability or low levels.
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