Table 2.
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Characteristics of Surgical Procedures and Antibiotic Therapy in 98 Patients With Total Hip or Knee Prosthesis Infection Due to Staphylococcus aureus According to Outcome

CharacteristicRemission (n = 77)Treatment failure (n = 21)P
Delay from onset of infection to revision, mean days ± SD119.4 ± 238.279 ± 111.7.80
Removal of all infected implants45 (58.4)12 (57.1).99
Gentamicin-loaded cement spacera27 (35.1)7 (33.3).84
Adequate empirical postsurgical antibiotic therapyb73 (94.8)17 (80.9).04
Rifampin-fluoroquinolone combination therapy37 (48.1)2 (9.5).001
Rifampin combination therapy58 (75.3)10 (47.6).002
Total duration of antibiotic therapy, mean days ± SD165.7 ± 108.8145.1 ± 101.6.44
CharacteristicRemission (n = 77)Treatment failure (n = 21)P
Delay from onset of infection to revision, mean days ± SD119.4 ± 238.279 ± 111.7.80
Removal of all infected implants45 (58.4)12 (57.1).99
Gentamicin-loaded cement spacera27 (35.1)7 (33.3).84
Adequate empirical postsurgical antibiotic therapyb73 (94.8)17 (80.9).04
Rifampin-fluoroquinolone combination therapy37 (48.1)2 (9.5).001
Rifampin combination therapy58 (75.3)10 (47.6).002
Total duration of antibiotic therapy, mean days ± SD165.7 ± 108.8145.1 ± 101.6.44

NOTE.  Data are no. (%) of patients unless otherwise indicated. SD, standard deviation.

a

Including 26 patients with 2-stage replacement and 8 with arthrodesis.

b

At least 1 antibiotic agent active against intraoperative pathogen(s).

Table 2.
Open in new tab

Characteristics of Surgical Procedures and Antibiotic Therapy in 98 Patients With Total Hip or Knee Prosthesis Infection Due to Staphylococcus aureus According to Outcome

CharacteristicRemission (n = 77)Treatment failure (n = 21)P
Delay from onset of infection to revision, mean days ± SD119.4 ± 238.279 ± 111.7.80
Removal of all infected implants45 (58.4)12 (57.1).99
Gentamicin-loaded cement spacera27 (35.1)7 (33.3).84
Adequate empirical postsurgical antibiotic therapyb73 (94.8)17 (80.9).04
Rifampin-fluoroquinolone combination therapy37 (48.1)2 (9.5).001
Rifampin combination therapy58 (75.3)10 (47.6).002
Total duration of antibiotic therapy, mean days ± SD165.7 ± 108.8145.1 ± 101.6.44
CharacteristicRemission (n = 77)Treatment failure (n = 21)P
Delay from onset of infection to revision, mean days ± SD119.4 ± 238.279 ± 111.7.80
Removal of all infected implants45 (58.4)12 (57.1).99
Gentamicin-loaded cement spacera27 (35.1)7 (33.3).84
Adequate empirical postsurgical antibiotic therapyb73 (94.8)17 (80.9).04
Rifampin-fluoroquinolone combination therapy37 (48.1)2 (9.5).001
Rifampin combination therapy58 (75.3)10 (47.6).002
Total duration of antibiotic therapy, mean days ± SD165.7 ± 108.8145.1 ± 101.6.44

NOTE.  Data are no. (%) of patients unless otherwise indicated. SD, standard deviation.

a

Including 26 patients with 2-stage replacement and 8 with arthrodesis.

b

At least 1 antibiotic agent active against intraoperative pathogen(s).

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