Longitudinal Study of Diabetes: ORs of MT2A A-5G Genotypes for the Risk of Diabetes Derived from Logistic Regression Analysis
| . | MT2A A-5G Genotype . | Confounders . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | AA (n = 2178) . | GA (n = 457) . | GG (n = 21) . | Age (/year) . | Sex (women) . | BMI (/kg· m−2) . | Smoking status (current) . | Alcohol intake (current) . | Energy intake (/kcal· day−1) . | Physical activity (/METs·day−1) . |
| Crude modela | 1 (Reference) | 1.86(1.11, 3.11) | — | |||||||
| Basic adjustment modelb | 1 (Reference) | 2.08(1.22, 3.53) | — | 1.06(1.03, 1.09) | 0.77 (0.48, 1.25) | 1.28(1.20, 3.53) | ||||
| Full modelc | 1 (Reference) | 2.06(1.21, 3.50) | — | 1.06(1.03, 1.09) | 0.71 (0.40, 1.29) | 1.27(1.20, 1.36) | 1.96 (0.89, 4.28) | 0.55(0.32, 0.95) | 1.000 0.999, 1.000) | 0.985 (0.959, 1.012) |
| . | MT2A A-5G Genotype . | Confounders . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | AA (n = 2178) . | GA (n = 457) . | GG (n = 21) . | Age (/year) . | Sex (women) . | BMI (/kg· m−2) . | Smoking status (current) . | Alcohol intake (current) . | Energy intake (/kcal· day−1) . | Physical activity (/METs·day−1) . |
| Crude modela | 1 (Reference) | 1.86(1.11, 3.11) | — | |||||||
| Basic adjustment modelb | 1 (Reference) | 2.08(1.22, 3.53) | — | 1.06(1.03, 1.09) | 0.77 (0.48, 1.25) | 1.28(1.20, 3.53) | ||||
| Full modelc | 1 (Reference) | 2.06(1.21, 3.50) | — | 1.06(1.03, 1.09) | 0.71 (0.40, 1.29) | 1.27(1.20, 1.36) | 1.96 (0.89, 4.28) | 0.55(0.32, 0.95) | 1.000 0.999, 1.000) | 0.985 (0.959, 1.012) |
BMI, body mass index; eGFR, estimated glomerular filtration rate; METs, metabolic equivalents.
Table items show ORs and their 95% CIs (lower, upper) for each genotype of MT2A A-5G and confounders. ORs are calculated from coefficients of logistic regression models. P values < .05 are shown in bold text and P < .01 are underlined. Since there was no DM case in GG genotype group, OR for GG could not be calculated and left blank.
aCrude effect of the polymorphism without any confounders.
bAdjusted for basic confounders: age, sex, and BMI.
cAdjusted for all possible confounders in addition to the basic adjustment model: smoking status, alcohol drinking habit, daily energy intake, and physical activity.
Longitudinal Study of Diabetes: ORs of MT2A A-5G Genotypes for the Risk of Diabetes Derived from Logistic Regression Analysis
| . | MT2A A-5G Genotype . | Confounders . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | AA (n = 2178) . | GA (n = 457) . | GG (n = 21) . | Age (/year) . | Sex (women) . | BMI (/kg· m−2) . | Smoking status (current) . | Alcohol intake (current) . | Energy intake (/kcal· day−1) . | Physical activity (/METs·day−1) . |
| Crude modela | 1 (Reference) | 1.86(1.11, 3.11) | — | |||||||
| Basic adjustment modelb | 1 (Reference) | 2.08(1.22, 3.53) | — | 1.06(1.03, 1.09) | 0.77 (0.48, 1.25) | 1.28(1.20, 3.53) | ||||
| Full modelc | 1 (Reference) | 2.06(1.21, 3.50) | — | 1.06(1.03, 1.09) | 0.71 (0.40, 1.29) | 1.27(1.20, 1.36) | 1.96 (0.89, 4.28) | 0.55(0.32, 0.95) | 1.000 0.999, 1.000) | 0.985 (0.959, 1.012) |
| . | MT2A A-5G Genotype . | Confounders . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | AA (n = 2178) . | GA (n = 457) . | GG (n = 21) . | Age (/year) . | Sex (women) . | BMI (/kg· m−2) . | Smoking status (current) . | Alcohol intake (current) . | Energy intake (/kcal· day−1) . | Physical activity (/METs·day−1) . |
| Crude modela | 1 (Reference) | 1.86(1.11, 3.11) | — | |||||||
| Basic adjustment modelb | 1 (Reference) | 2.08(1.22, 3.53) | — | 1.06(1.03, 1.09) | 0.77 (0.48, 1.25) | 1.28(1.20, 3.53) | ||||
| Full modelc | 1 (Reference) | 2.06(1.21, 3.50) | — | 1.06(1.03, 1.09) | 0.71 (0.40, 1.29) | 1.27(1.20, 1.36) | 1.96 (0.89, 4.28) | 0.55(0.32, 0.95) | 1.000 0.999, 1.000) | 0.985 (0.959, 1.012) |
BMI, body mass index; eGFR, estimated glomerular filtration rate; METs, metabolic equivalents.
Table items show ORs and their 95% CIs (lower, upper) for each genotype of MT2A A-5G and confounders. ORs are calculated from coefficients of logistic regression models. P values < .05 are shown in bold text and P < .01 are underlined. Since there was no DM case in GG genotype group, OR for GG could not be calculated and left blank.
aCrude effect of the polymorphism without any confounders.
bAdjusted for basic confounders: age, sex, and BMI.
cAdjusted for all possible confounders in addition to the basic adjustment model: smoking status, alcohol drinking habit, daily energy intake, and physical activity.
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