Background Profiles in Subjects for Longitudinal Studies of CKD and Diabetes by MT2A A-5G Genotype
| Cohort . | . | MT2A A-5G Genotype . | P . | ||
|---|---|---|---|---|---|
| AA . | GA . | GG . | |||
| For CKD study (n = 2649) | Number of subjects | 2168 (81.8%) | 462 (17.4%) | 19 (0.7%) | — |
| CKD at baseline survey (samples excluded) | 101 | 21 | 2 | .412 | |
| Age (years) | 58.7 ± 9.8 | 58.6 ± 10.0 | 59.2 ± 7.5 | .995 | |
| Men | 571 (26.3%) | 126 (27.3%) | 3 (12.8%) | .586 | |
| BMI (kg/m2) | 21.7 ± 3.2 | 21.4 ± 2.9 | 21.3 ± 2.6 | .316 | |
| Current smokers | 162 (7.5%) | 28 (6.1%) | 6 (31.6%) | .002 | |
| Current alcohol drinkers | 1145 (52.8%) | 241 (52.2%) | 8 (42.1%) | .632 | |
| HT | 516 (23.8%) | 113 (24.5%) | 5 (26.3%) | .875 | |
| CKD | 251 (11.5%) | 44 (9.5%) | 5 (26.3%) | .054 | |
| ΔeGFR (ml/min/1.73 m2) | −10.5 ± 8.8 | −10.1 ± 8.6 | −14.5 ± 8.4 | .088 | |
| For DM study (n = 2656) | Number of subjects | 2178 (82.0%) | 457 (17.2%) | 21 (0.8%) | |
| DM at baseline survey (samples excluded) | 88 (91a) | 26 (27a) | 0 (0) | .227 | |
| Age (years) | 58.8 ± 9.8 | 58.6 ± 10.1 | 59.5 ± 8.0 | .964 | |
| Men | 554 (25.4%) | 121 (26.5%) | 4 (19.0%) | .748 | |
| BMI (kg/m2) | 21.6 ± 3.1 | 21.4 ± 2.9 | 21.4 ± 2.5 | .342 | |
| Current smokers | 152 (7.0%) | 29 (6.3%) | 6 (28.6%) | .005 | |
| Current alcohol drinkers | 1146 (52.6%) | 243 (53.2%) | 10 (47.6%) | .868 | |
| Energy intake (kcal/d) | 2,362 ± 927 | 2,305 ± 941 | 2,089 ± 715 | .211 | |
| Physical activity (METs/d) | 37.4 ± 9.0 | 37.5 ± 8.9 | 41.4 ± 10.7 | .130 | |
| Diabetes | 55 (2.5%) | 21 (4.6%) | 0 | .058 | |
| Cohort . | . | MT2A A-5G Genotype . | P . | ||
|---|---|---|---|---|---|
| AA . | GA . | GG . | |||
| For CKD study (n = 2649) | Number of subjects | 2168 (81.8%) | 462 (17.4%) | 19 (0.7%) | — |
| CKD at baseline survey (samples excluded) | 101 | 21 | 2 | .412 | |
| Age (years) | 58.7 ± 9.8 | 58.6 ± 10.0 | 59.2 ± 7.5 | .995 | |
| Men | 571 (26.3%) | 126 (27.3%) | 3 (12.8%) | .586 | |
| BMI (kg/m2) | 21.7 ± 3.2 | 21.4 ± 2.9 | 21.3 ± 2.6 | .316 | |
| Current smokers | 162 (7.5%) | 28 (6.1%) | 6 (31.6%) | .002 | |
| Current alcohol drinkers | 1145 (52.8%) | 241 (52.2%) | 8 (42.1%) | .632 | |
| HT | 516 (23.8%) | 113 (24.5%) | 5 (26.3%) | .875 | |
| CKD | 251 (11.5%) | 44 (9.5%) | 5 (26.3%) | .054 | |
| ΔeGFR (ml/min/1.73 m2) | −10.5 ± 8.8 | −10.1 ± 8.6 | −14.5 ± 8.4 | .088 | |
| For DM study (n = 2656) | Number of subjects | 2178 (82.0%) | 457 (17.2%) | 21 (0.8%) | |
| DM at baseline survey (samples excluded) | 88 (91a) | 26 (27a) | 0 (0) | .227 | |
| Age (years) | 58.8 ± 9.8 | 58.6 ± 10.1 | 59.5 ± 8.0 | .964 | |
| Men | 554 (25.4%) | 121 (26.5%) | 4 (19.0%) | .748 | |
| BMI (kg/m2) | 21.6 ± 3.1 | 21.4 ± 2.9 | 21.4 ± 2.5 | .342 | |
| Current smokers | 152 (7.0%) | 29 (6.3%) | 6 (28.6%) | .005 | |
| Current alcohol drinkers | 1146 (52.6%) | 243 (53.2%) | 10 (47.6%) | .868 | |
| Energy intake (kcal/d) | 2,362 ± 927 | 2,305 ± 941 | 2,089 ± 715 | .211 | |
| Physical activity (METs/d) | 37.4 ± 9.0 | 37.5 ± 8.9 | 41.4 ± 10.7 | .130 | |
| Diabetes | 55 (2.5%) | 21 (4.6%) | 0 | .058 | |
DM, diabetes mellitus; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; METs, metabolic equivalents.
± values indicate mean ± SD. P values < .05 are bolded.
aNumbers including participants without available data on DM at baseline survey.
Background Profiles in Subjects for Longitudinal Studies of CKD and Diabetes by MT2A A-5G Genotype
| Cohort . | . | MT2A A-5G Genotype . | P . | ||
|---|---|---|---|---|---|
| AA . | GA . | GG . | |||
| For CKD study (n = 2649) | Number of subjects | 2168 (81.8%) | 462 (17.4%) | 19 (0.7%) | — |
| CKD at baseline survey (samples excluded) | 101 | 21 | 2 | .412 | |
| Age (years) | 58.7 ± 9.8 | 58.6 ± 10.0 | 59.2 ± 7.5 | .995 | |
| Men | 571 (26.3%) | 126 (27.3%) | 3 (12.8%) | .586 | |
| BMI (kg/m2) | 21.7 ± 3.2 | 21.4 ± 2.9 | 21.3 ± 2.6 | .316 | |
| Current smokers | 162 (7.5%) | 28 (6.1%) | 6 (31.6%) | .002 | |
| Current alcohol drinkers | 1145 (52.8%) | 241 (52.2%) | 8 (42.1%) | .632 | |
| HT | 516 (23.8%) | 113 (24.5%) | 5 (26.3%) | .875 | |
| CKD | 251 (11.5%) | 44 (9.5%) | 5 (26.3%) | .054 | |
| ΔeGFR (ml/min/1.73 m2) | −10.5 ± 8.8 | −10.1 ± 8.6 | −14.5 ± 8.4 | .088 | |
| For DM study (n = 2656) | Number of subjects | 2178 (82.0%) | 457 (17.2%) | 21 (0.8%) | |
| DM at baseline survey (samples excluded) | 88 (91a) | 26 (27a) | 0 (0) | .227 | |
| Age (years) | 58.8 ± 9.8 | 58.6 ± 10.1 | 59.5 ± 8.0 | .964 | |
| Men | 554 (25.4%) | 121 (26.5%) | 4 (19.0%) | .748 | |
| BMI (kg/m2) | 21.6 ± 3.1 | 21.4 ± 2.9 | 21.4 ± 2.5 | .342 | |
| Current smokers | 152 (7.0%) | 29 (6.3%) | 6 (28.6%) | .005 | |
| Current alcohol drinkers | 1146 (52.6%) | 243 (53.2%) | 10 (47.6%) | .868 | |
| Energy intake (kcal/d) | 2,362 ± 927 | 2,305 ± 941 | 2,089 ± 715 | .211 | |
| Physical activity (METs/d) | 37.4 ± 9.0 | 37.5 ± 8.9 | 41.4 ± 10.7 | .130 | |
| Diabetes | 55 (2.5%) | 21 (4.6%) | 0 | .058 | |
| Cohort . | . | MT2A A-5G Genotype . | P . | ||
|---|---|---|---|---|---|
| AA . | GA . | GG . | |||
| For CKD study (n = 2649) | Number of subjects | 2168 (81.8%) | 462 (17.4%) | 19 (0.7%) | — |
| CKD at baseline survey (samples excluded) | 101 | 21 | 2 | .412 | |
| Age (years) | 58.7 ± 9.8 | 58.6 ± 10.0 | 59.2 ± 7.5 | .995 | |
| Men | 571 (26.3%) | 126 (27.3%) | 3 (12.8%) | .586 | |
| BMI (kg/m2) | 21.7 ± 3.2 | 21.4 ± 2.9 | 21.3 ± 2.6 | .316 | |
| Current smokers | 162 (7.5%) | 28 (6.1%) | 6 (31.6%) | .002 | |
| Current alcohol drinkers | 1145 (52.8%) | 241 (52.2%) | 8 (42.1%) | .632 | |
| HT | 516 (23.8%) | 113 (24.5%) | 5 (26.3%) | .875 | |
| CKD | 251 (11.5%) | 44 (9.5%) | 5 (26.3%) | .054 | |
| ΔeGFR (ml/min/1.73 m2) | −10.5 ± 8.8 | −10.1 ± 8.6 | −14.5 ± 8.4 | .088 | |
| For DM study (n = 2656) | Number of subjects | 2178 (82.0%) | 457 (17.2%) | 21 (0.8%) | |
| DM at baseline survey (samples excluded) | 88 (91a) | 26 (27a) | 0 (0) | .227 | |
| Age (years) | 58.8 ± 9.8 | 58.6 ± 10.1 | 59.5 ± 8.0 | .964 | |
| Men | 554 (25.4%) | 121 (26.5%) | 4 (19.0%) | .748 | |
| BMI (kg/m2) | 21.6 ± 3.1 | 21.4 ± 2.9 | 21.4 ± 2.5 | .342 | |
| Current smokers | 152 (7.0%) | 29 (6.3%) | 6 (28.6%) | .005 | |
| Current alcohol drinkers | 1146 (52.6%) | 243 (53.2%) | 10 (47.6%) | .868 | |
| Energy intake (kcal/d) | 2,362 ± 927 | 2,305 ± 941 | 2,089 ± 715 | .211 | |
| Physical activity (METs/d) | 37.4 ± 9.0 | 37.5 ± 8.9 | 41.4 ± 10.7 | .130 | |
| Diabetes | 55 (2.5%) | 21 (4.6%) | 0 | .058 | |
DM, diabetes mellitus; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; METs, metabolic equivalents.
± values indicate mean ± SD. P values < .05 are bolded.
aNumbers including participants without available data on DM at baseline survey.
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