Table 4. Open in new tab Univariate and...

	Boys	Girls
Free T4 continuous, pmol/L	10.6	0.81 (0.71–0.91)^b	0.79 (0.69–0.90)^b	8.4	0.93 (0.82–1.05)	0.95 (0.84–1.09)
Free T4 quintiles
Q1	14.4	Reference	Reference	7.8	Reference	Reference
Q2	11.9	0.80 (0.53–1.21)	0.72 (0.46–1.12)	10.6	1.41 (0.87–2.28)	1.50 (0.91–2.47)
Q3	11.1	0.73 (0.47–1.11)	0.66 (0.42–1.04)	8.7	1.13 (0.68–1.85)	1.20 (0.72; 2.01)
Q4	9.1	0.59 (0.38–0.93)^a	0.59 (0.36–0.94)^a	7.4	0.94 (0.56–1.57)	0.99 (0.58; 1.70)
Q5	6.5	0.42 (0.26–0.68)^b	0.38 (0.22–0.63)^b	7.5	0.95 (0.57–1.60)	1.09 (0.63–1.86)
TSH continuous, mU/L	10.6	1.13 (0.98–1.37)^a	1.09 (0.93–1.27)	8.4	1.07 (0.93–1.22)	1.01 (0.86–1.18)
TSH quintiles
Q1	8.8	Reference	Reference	5.9	Reference	Reference
Q2	8.5	0.96 (0.58–1.60)	0.98 (0.58–1.67)	8.7	1.52 (0.90–2.58)	1.49 (0.87–2.55)
Q3	12.7	1.48 (0.92–2.40)	1.38 (0.84–2.28)	7.7	1.32 (0.77–2.26)	1.20 (0.69–2.07)
Q4	11.1	1.26 (0.77–2.06)	1.15 (0.69–1.93)	9.3	1.63 (0.97–2.74)	1.46 (0.85–2.48)
Q5	11.7	1.36 (0.84–2.21)	1.16 (0.70–1.92)	10.9	1.94 (1.17–3.24)^a	1.65 (0.97–2.81)

Boys

Girls

% LGA

OR (95% CI)

% LGA

OR (95% CI)

Model 1

Model 2

Model 1

Model 2

Free T4 continuous, pmol/L

10.6

0.81 (0.71–0.91)^b

0.79 (0.69–0.90)^b

8.4

0.93 (0.82–1.05)

0.95 (0.84–1.09)

Free T4 quintiles

14.4

Reference

7.8

Reference

11.9

0.80 (0.53–1.21)

0.72 (0.46–1.12)

10.6

1.41 (0.87–2.28)

1.50 (0.91–2.47)

11.1

0.73 (0.47–1.11)

0.66 (0.42–1.04)

8.7

1.13 (0.68–1.85)

1.20 (0.72; 2.01)

9.1

0.59 (0.38–0.93)^a

0.59 (0.36–0.94)^a

7.4

0.94 (0.56–1.57)

0.99 (0.58; 1.70)

6.5

0.42 (0.26–0.68)^b

0.38 (0.22–0.63)^b

7.5

0.95 (0.57–1.60)

1.09 (0.63–1.86)

TSH continuous, mU/L

10.6

1.13 (0.98–1.37)^a

1.09 (0.93–1.27)

8.4

1.07 (0.93–1.22)

1.01 (0.86–1.18)

TSH quintiles

8.8

Reference

5.9

Reference

8.5

0.96 (0.58–1.60)

0.98 (0.58–1.67)

8.7

1.52 (0.90–2.58)

1.49 (0.87–2.55)

12.7

1.48 (0.92–2.40)

1.38 (0.84–2.28)

7.7

1.32 (0.77–2.26)

1.20 (0.69–2.07)

11.1

1.26 (0.77–2.06)

1.15 (0.69–1.93)

9.3

1.63 (0.97–2.74)

1.46 (0.85–2.48)

11.7

1.36 (0.84–2.21)

1.16 (0.70–1.92)

10.9

1.94 (1.17–3.24)^a

1.65 (0.97–2.81)

	Boys	Girls
Free T4 continuous, pmol/L	10.6	0.81 (0.71–0.91)^b	0.79 (0.69–0.90)^b	8.4	0.93 (0.82–1.05)	0.95 (0.84–1.09)
Free T4 quintiles
Q1	14.4	Reference	Reference	7.8	Reference	Reference
Q2	11.9	0.80 (0.53–1.21)	0.72 (0.46–1.12)	10.6	1.41 (0.87–2.28)	1.50 (0.91–2.47)
Q3	11.1	0.73 (0.47–1.11)	0.66 (0.42–1.04)	8.7	1.13 (0.68–1.85)	1.20 (0.72; 2.01)
Q4	9.1	0.59 (0.38–0.93)^a	0.59 (0.36–0.94)^a	7.4	0.94 (0.56–1.57)	0.99 (0.58; 1.70)
Q5	6.5	0.42 (0.26–0.68)^b	0.38 (0.22–0.63)^b	7.5	0.95 (0.57–1.60)	1.09 (0.63–1.86)
TSH continuous, mU/L	10.6	1.13 (0.98–1.37)^a	1.09 (0.93–1.27)	8.4	1.07 (0.93–1.22)	1.01 (0.86–1.18)
TSH quintiles
Q1	8.8	Reference	Reference	5.9	Reference	Reference
Q2	8.5	0.96 (0.58–1.60)	0.98 (0.58–1.67)	8.7	1.52 (0.90–2.58)	1.49 (0.87–2.55)
Q3	12.7	1.48 (0.92–2.40)	1.38 (0.84–2.28)	7.7	1.32 (0.77–2.26)	1.20 (0.69–2.07)
Q4	11.1	1.26 (0.77–2.06)	1.15 (0.69–1.93)	9.3	1.63 (0.97–2.74)	1.46 (0.85–2.48)
Q5	11.7	1.36 (0.84–2.21)	1.16 (0.70–1.92)	10.9	1.94 (1.17–3.24)^a	1.65 (0.97–2.81)

Table 4.

Open in new tab

Univariate and Multivariate Associations Between Maternal fT4 and TSH and Odds of LGA Infant, Stratified by Fetal Sex

	Boys			Girls
	% LGA	OR (95% CI)		% LGA	OR (95% CI)
	% LGA	Model 1	Model 2	% LGA	Model 1	Model 2
Free T4 continuous, pmol/L	10.6	0.81 (0.71–0.91)^b	0.79 (0.69–0.90)^b	8.4	0.93 (0.82–1.05)	0.95 (0.84–1.09)
Free T4 quintiles
Q1	14.4	Reference	Reference	7.8	Reference	Reference
Q2	11.9	0.80 (0.53–1.21)	0.72 (0.46–1.12)	10.6	1.41 (0.87–2.28)	1.50 (0.91–2.47)
Q3	11.1	0.73 (0.47–1.11)	0.66 (0.42–1.04)	8.7	1.13 (0.68–1.85)	1.20 (0.72; 2.01)
Q4	9.1	0.59 (0.38–0.93)^a	0.59 (0.36–0.94)^a	7.4	0.94 (0.56–1.57)	0.99 (0.58; 1.70)
Q5	6.5	0.42 (0.26–0.68)^b	0.38 (0.22–0.63)^b	7.5	0.95 (0.57–1.60)	1.09 (0.63–1.86)
TSH continuous, mU/L	10.6	1.13 (0.98–1.37)^a	1.09 (0.93–1.27)	8.4	1.07 (0.93–1.22)	1.01 (0.86–1.18)
TSH quintiles
Q1	8.8	Reference	Reference	5.9	Reference	Reference
Q2	8.5	0.96 (0.58–1.60)	0.98 (0.58–1.67)	8.7	1.52 (0.90–2.58)	1.49 (0.87–2.55)
Q3	12.7	1.48 (0.92–2.40)	1.38 (0.84–2.28)	7.7	1.32 (0.77–2.26)	1.20 (0.69–2.07)
Q4	11.1	1.26 (0.77–2.06)	1.15 (0.69–1.93)	9.3	1.63 (0.97–2.74)	1.46 (0.85–2.48)
Q5	11.7	1.36 (0.84–2.21)	1.16 (0.70–1.92)	10.9	1.94 (1.17–3.24)^a	1.65 (0.97–2.81)

	Boys			Girls
	% LGA	OR (95% CI)		% LGA	OR (95% CI)
	% LGA	Model 1	Model 2	% LGA	Model 1	Model 2
Free T4 continuous, pmol/L	10.6	0.81 (0.71–0.91)^b	0.79 (0.69–0.90)^b	8.4	0.93 (0.82–1.05)	0.95 (0.84–1.09)
Free T4 quintiles
Q1	14.4	Reference	Reference	7.8	Reference	Reference
Q2	11.9	0.80 (0.53–1.21)	0.72 (0.46–1.12)	10.6	1.41 (0.87–2.28)	1.50 (0.91–2.47)
Q3	11.1	0.73 (0.47–1.11)	0.66 (0.42–1.04)	8.7	1.13 (0.68–1.85)	1.20 (0.72; 2.01)
Q4	9.1	0.59 (0.38–0.93)^a	0.59 (0.36–0.94)^a	7.4	0.94 (0.56–1.57)	0.99 (0.58; 1.70)
Q5	6.5	0.42 (0.26–0.68)^b	0.38 (0.22–0.63)^b	7.5	0.95 (0.57–1.60)	1.09 (0.63–1.86)
TSH continuous, mU/L	10.6	1.13 (0.98–1.37)^a	1.09 (0.93–1.27)	8.4	1.07 (0.93–1.22)	1.01 (0.86–1.18)
TSH quintiles
Q1	8.8	Reference	Reference	5.9	Reference	Reference
Q2	8.5	0.96 (0.58–1.60)	0.98 (0.58–1.67)	8.7	1.52 (0.90–2.58)	1.49 (0.87–2.55)
Q3	12.7	1.48 (0.92–2.40)	1.38 (0.84–2.28)	7.7	1.32 (0.77–2.26)	1.20 (0.69–2.07)
Q4	11.1	1.26 (0.77–2.06)	1.15 (0.69–1.93)	9.3	1.63 (0.97–2.74)	1.46 (0.85–2.48)
Q5	11.7	1.36 (0.84–2.21)	1.16 (0.70–1.92)	10.9	1.94 (1.17–3.24)^a	1.65 (0.97–2.81)

Model 1 was adjusted for gestational age at blood sampling. Model 2 was adjusted for model 1 plus maternal height, ethnicity, educational level, smoking, pBMI, diabetes, hypertension, and anti-TPO positivity.

P < 0.05.

P < 0.001.

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