Table 3.
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COH Results Comparison Between Nonprimed Cycles and Primed Cycles (Phase 1 vs Phase 2) and Comparison Between Primed Cycles According to Intervention

T GroupE GroupEOCP GroupOverall Population
NonprimedPrimedNonprimedPrimedNonprimedPrimedNonprimedPrimed
FSH day 3, mIU/mL12.3 ± 6.110.3 ± 4.1a12.5 ± 6.2b4.9 ± 4.2a,b9.5 ± 4.911.1 ± 7.5a11.5 ± 5.9g8.5 ± 6.1g
AFC day 34.9 ± 1.54.8 ± 2.44.9 ± 2.35.9 ± 3.44.4 ± 1.84.2 ± 2.54.7 ± 1.95.0 ± 2.9
Days of stimulation8.9 ± 2.99.4 ± 2.19.6 ± 2.3c11.1 ± 2.5c10.9 ± 3.39.4 ± 2.29.7 ± 2.910 ± 2.4
Total IU of FSH2700 ± 8882810 ± 6422871 ± 7003271 ± 7993264 ± 9882841 ± 6722931 ± 8722989 ± 732
E2 on ovulation trigger day, pg/mL812.1 ± 391.9891.2 ± 516.9857.1 ± 511.71038 ± 469895.2 ± 394.4865 ± 322851.9 ± 429933.9 ± 450
Endometrial thickness on ovulation trigger day, mm9.6 ± 1.99.8 ± 2.39.7 ± 1.910.2 ± 1.911.0 ± 2.59.6 ± 1.610.0 ± 2.19.8 ± 1.7
No. of follicles >16 mm2.4 ± 1.22.4 ± 1.02.7 ± 1.6d3.8 ± 2.0d3.3 ± 1.52.3 ± 1.32.8 ± 1.42.8 ± 1.6
No. of oocytes retrieved2.3 ± 1.92.7 ± 1.92.2 ± 1.3e3.6 ± 2.5e2.3 ± 1.72.2 ± 1.22.2 ± 1.6h2.9 ± 2.0h
No. of MII oocytes retrieved1.8 ± 1.52.2 ± 2.01.6 ± 1.2f2.7 ± 1.7f1.9 ± 1.22.0 ± 1.31.7 ± 1.3i2.4 ± 1.7i
Pregnancy rate, n (%)0j7 (31.8)j2 (8.3)6 (25)04 (20)2 (3)k17 (25.7)k
Live birth rate, n (%)05 (22.7)03 (12.5)03 (15)0l11 (16.7)l
T GroupE GroupEOCP GroupOverall Population
NonprimedPrimedNonprimedPrimedNonprimedPrimedNonprimedPrimed
FSH day 3, mIU/mL12.3 ± 6.110.3 ± 4.1a12.5 ± 6.2b4.9 ± 4.2a,b9.5 ± 4.911.1 ± 7.5a11.5 ± 5.9g8.5 ± 6.1g
AFC day 34.9 ± 1.54.8 ± 2.44.9 ± 2.35.9 ± 3.44.4 ± 1.84.2 ± 2.54.7 ± 1.95.0 ± 2.9
Days of stimulation8.9 ± 2.99.4 ± 2.19.6 ± 2.3c11.1 ± 2.5c10.9 ± 3.39.4 ± 2.29.7 ± 2.910 ± 2.4
Total IU of FSH2700 ± 8882810 ± 6422871 ± 7003271 ± 7993264 ± 9882841 ± 6722931 ± 8722989 ± 732
E2 on ovulation trigger day, pg/mL812.1 ± 391.9891.2 ± 516.9857.1 ± 511.71038 ± 469895.2 ± 394.4865 ± 322851.9 ± 429933.9 ± 450
Endometrial thickness on ovulation trigger day, mm9.6 ± 1.99.8 ± 2.39.7 ± 1.910.2 ± 1.911.0 ± 2.59.6 ± 1.610.0 ± 2.19.8 ± 1.7
No. of follicles >16 mm2.4 ± 1.22.4 ± 1.02.7 ± 1.6d3.8 ± 2.0d3.3 ± 1.52.3 ± 1.32.8 ± 1.42.8 ± 1.6
No. of oocytes retrieved2.3 ± 1.92.7 ± 1.92.2 ± 1.3e3.6 ± 2.5e2.3 ± 1.72.2 ± 1.22.2 ± 1.6h2.9 ± 2.0h
No. of MII oocytes retrieved1.8 ± 1.52.2 ± 2.01.6 ± 1.2f2.7 ± 1.7f1.9 ± 1.22.0 ± 1.31.7 ± 1.3i2.4 ± 1.7i
Pregnancy rate, n (%)0j7 (31.8)j2 (8.3)6 (25)04 (20)2 (3)k17 (25.7)k
Live birth rate, n (%)05 (22.7)03 (12.5)03 (15)0l11 (16.7)l

Continuous variables were tested for normality using the Kolmogorov-Smirnov test; data are expressed as means ± SD if normally distributed. Comparisons between arms (primed cycles) were analyzed using one-way ANOVA followed by the Bonferroni test using a P value adjusted to 0.016. Comparisons within patients (primed vs nonprimed cycles) were done using the Student t test for paired samples. Differences were considered significant at P < .05 or P < .016, and they are marked with superscripts: a E group vs T group: P = .009; E group vs EOCP group , P = .003;

b

primed vs nonprimed, P < .001;

c

primed vs nonprimed, P = .032;

d

primed vs nonprimed, P = .021;

e

primed vs nonprimed, P = .033;

f

primed vs nonprimed, P = .029;

g

primed vs nonprimed, P = .011;

h

primed vs nonprimed, P = .031;

i

primed vs nonprimed, P = .026;

j

primed vs nonprimed, P = .03;

k

primed vs nonprimed, P = .002;

l

primed vs nonprimed, P = .002.

Table 3.
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COH Results Comparison Between Nonprimed Cycles and Primed Cycles (Phase 1 vs Phase 2) and Comparison Between Primed Cycles According to Intervention

T GroupE GroupEOCP GroupOverall Population
NonprimedPrimedNonprimedPrimedNonprimedPrimedNonprimedPrimed
FSH day 3, mIU/mL12.3 ± 6.110.3 ± 4.1a12.5 ± 6.2b4.9 ± 4.2a,b9.5 ± 4.911.1 ± 7.5a11.5 ± 5.9g8.5 ± 6.1g
AFC day 34.9 ± 1.54.8 ± 2.44.9 ± 2.35.9 ± 3.44.4 ± 1.84.2 ± 2.54.7 ± 1.95.0 ± 2.9
Days of stimulation8.9 ± 2.99.4 ± 2.19.6 ± 2.3c11.1 ± 2.5c10.9 ± 3.39.4 ± 2.29.7 ± 2.910 ± 2.4
Total IU of FSH2700 ± 8882810 ± 6422871 ± 7003271 ± 7993264 ± 9882841 ± 6722931 ± 8722989 ± 732
E2 on ovulation trigger day, pg/mL812.1 ± 391.9891.2 ± 516.9857.1 ± 511.71038 ± 469895.2 ± 394.4865 ± 322851.9 ± 429933.9 ± 450
Endometrial thickness on ovulation trigger day, mm9.6 ± 1.99.8 ± 2.39.7 ± 1.910.2 ± 1.911.0 ± 2.59.6 ± 1.610.0 ± 2.19.8 ± 1.7
No. of follicles >16 mm2.4 ± 1.22.4 ± 1.02.7 ± 1.6d3.8 ± 2.0d3.3 ± 1.52.3 ± 1.32.8 ± 1.42.8 ± 1.6
No. of oocytes retrieved2.3 ± 1.92.7 ± 1.92.2 ± 1.3e3.6 ± 2.5e2.3 ± 1.72.2 ± 1.22.2 ± 1.6h2.9 ± 2.0h
No. of MII oocytes retrieved1.8 ± 1.52.2 ± 2.01.6 ± 1.2f2.7 ± 1.7f1.9 ± 1.22.0 ± 1.31.7 ± 1.3i2.4 ± 1.7i
Pregnancy rate, n (%)0j7 (31.8)j2 (8.3)6 (25)04 (20)2 (3)k17 (25.7)k
Live birth rate, n (%)05 (22.7)03 (12.5)03 (15)0l11 (16.7)l
T GroupE GroupEOCP GroupOverall Population
NonprimedPrimedNonprimedPrimedNonprimedPrimedNonprimedPrimed
FSH day 3, mIU/mL12.3 ± 6.110.3 ± 4.1a12.5 ± 6.2b4.9 ± 4.2a,b9.5 ± 4.911.1 ± 7.5a11.5 ± 5.9g8.5 ± 6.1g
AFC day 34.9 ± 1.54.8 ± 2.44.9 ± 2.35.9 ± 3.44.4 ± 1.84.2 ± 2.54.7 ± 1.95.0 ± 2.9
Days of stimulation8.9 ± 2.99.4 ± 2.19.6 ± 2.3c11.1 ± 2.5c10.9 ± 3.39.4 ± 2.29.7 ± 2.910 ± 2.4
Total IU of FSH2700 ± 8882810 ± 6422871 ± 7003271 ± 7993264 ± 9882841 ± 6722931 ± 8722989 ± 732
E2 on ovulation trigger day, pg/mL812.1 ± 391.9891.2 ± 516.9857.1 ± 511.71038 ± 469895.2 ± 394.4865 ± 322851.9 ± 429933.9 ± 450
Endometrial thickness on ovulation trigger day, mm9.6 ± 1.99.8 ± 2.39.7 ± 1.910.2 ± 1.911.0 ± 2.59.6 ± 1.610.0 ± 2.19.8 ± 1.7
No. of follicles >16 mm2.4 ± 1.22.4 ± 1.02.7 ± 1.6d3.8 ± 2.0d3.3 ± 1.52.3 ± 1.32.8 ± 1.42.8 ± 1.6
No. of oocytes retrieved2.3 ± 1.92.7 ± 1.92.2 ± 1.3e3.6 ± 2.5e2.3 ± 1.72.2 ± 1.22.2 ± 1.6h2.9 ± 2.0h
No. of MII oocytes retrieved1.8 ± 1.52.2 ± 2.01.6 ± 1.2f2.7 ± 1.7f1.9 ± 1.22.0 ± 1.31.7 ± 1.3i2.4 ± 1.7i
Pregnancy rate, n (%)0j7 (31.8)j2 (8.3)6 (25)04 (20)2 (3)k17 (25.7)k
Live birth rate, n (%)05 (22.7)03 (12.5)03 (15)0l11 (16.7)l

Continuous variables were tested for normality using the Kolmogorov-Smirnov test; data are expressed as means ± SD if normally distributed. Comparisons between arms (primed cycles) were analyzed using one-way ANOVA followed by the Bonferroni test using a P value adjusted to 0.016. Comparisons within patients (primed vs nonprimed cycles) were done using the Student t test for paired samples. Differences were considered significant at P < .05 or P < .016, and they are marked with superscripts: a E group vs T group: P = .009; E group vs EOCP group , P = .003;

b

primed vs nonprimed, P < .001;

c

primed vs nonprimed, P = .032;

d

primed vs nonprimed, P = .021;

e

primed vs nonprimed, P = .033;

f

primed vs nonprimed, P = .029;

g

primed vs nonprimed, P = .011;

h

primed vs nonprimed, P = .031;

i

primed vs nonprimed, P = .026;

j

primed vs nonprimed, P = .03;

k

primed vs nonprimed, P = .002;

l

primed vs nonprimed, P = .002.

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