| USPSTF . | OCEBM . | GRADE . | PORT . |
|---|---|---|---|
| Systematic review of randomized trials or n-of-1 trials | High quality | Level A: Good research-based evidence, with some expert opinion, to support the recommendation | |
| Level I: Evidence obtained from at least one properly designed randomized controlled trial. | Randomized trial or observational study with dramatic effect | ||
| Level II-1: Evidence obtained from well-designed controlled trials without randomization. | Medium quality | Level B: Fair research-based evidence, with substantial expert opinion, to support the recommendation | |
| Nonrandomized controlled cohort/follow-up study | Low quality | ||
| Level II-2: Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group. | Case-series, case-control studies, or historically controlled studies | Very low quality | |
| Level II-3: Evidence obtained from multiple time series designs with or without the intervention. Dramatic results in uncontrolled trials might also be regarded as this type of evidence. | |||
| Mechanism-based reasoning | Level C: Recommendation based primarily on expert opinion, with minimal research-based evidence, but significant clinical experience | ||
| Level III: Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees. |
| USPSTF . | OCEBM . | GRADE . | PORT . |
|---|---|---|---|
| Systematic review of randomized trials or n-of-1 trials | High quality | Level A: Good research-based evidence, with some expert opinion, to support the recommendation | |
| Level I: Evidence obtained from at least one properly designed randomized controlled trial. | Randomized trial or observational study with dramatic effect | ||
| Level II-1: Evidence obtained from well-designed controlled trials without randomization. | Medium quality | Level B: Fair research-based evidence, with substantial expert opinion, to support the recommendation | |
| Nonrandomized controlled cohort/follow-up study | Low quality | ||
| Level II-2: Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group. | Case-series, case-control studies, or historically controlled studies | Very low quality | |
| Level II-3: Evidence obtained from multiple time series designs with or without the intervention. Dramatic results in uncontrolled trials might also be regarded as this type of evidence. | |||
| Mechanism-based reasoning | Level C: Recommendation based primarily on expert opinion, with minimal research-based evidence, but significant clinical experience | ||
| Level III: Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees. |
| USPSTF . | OCEBM . | GRADE . | PORT . |
|---|---|---|---|
| Systematic review of randomized trials or n-of-1 trials | High quality | Level A: Good research-based evidence, with some expert opinion, to support the recommendation | |
| Level I: Evidence obtained from at least one properly designed randomized controlled trial. | Randomized trial or observational study with dramatic effect | ||
| Level II-1: Evidence obtained from well-designed controlled trials without randomization. | Medium quality | Level B: Fair research-based evidence, with substantial expert opinion, to support the recommendation | |
| Nonrandomized controlled cohort/follow-up study | Low quality | ||
| Level II-2: Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group. | Case-series, case-control studies, or historically controlled studies | Very low quality | |
| Level II-3: Evidence obtained from multiple time series designs with or without the intervention. Dramatic results in uncontrolled trials might also be regarded as this type of evidence. | |||
| Mechanism-based reasoning | Level C: Recommendation based primarily on expert opinion, with minimal research-based evidence, but significant clinical experience | ||
| Level III: Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees. |
| USPSTF . | OCEBM . | GRADE . | PORT . |
|---|---|---|---|
| Systematic review of randomized trials or n-of-1 trials | High quality | Level A: Good research-based evidence, with some expert opinion, to support the recommendation | |
| Level I: Evidence obtained from at least one properly designed randomized controlled trial. | Randomized trial or observational study with dramatic effect | ||
| Level II-1: Evidence obtained from well-designed controlled trials without randomization. | Medium quality | Level B: Fair research-based evidence, with substantial expert opinion, to support the recommendation | |
| Nonrandomized controlled cohort/follow-up study | Low quality | ||
| Level II-2: Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group. | Case-series, case-control studies, or historically controlled studies | Very low quality | |
| Level II-3: Evidence obtained from multiple time series designs with or without the intervention. Dramatic results in uncontrolled trials might also be regarded as this type of evidence. | |||
| Mechanism-based reasoning | Level C: Recommendation based primarily on expert opinion, with minimal research-based evidence, but significant clinical experience | ||
| Level III: Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees. |
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
