| Resistance mechanism . | GAS factor . | Function . |
|---|---|---|
| Surface/secreted protein | M protein | Impaired fusion of azurophilic granules with phagolysosome |
| HA capsule | H2O2 resistance by aggregation | |
| Mac-1 | Reduced phagocytosis and ROS production | |
| Mac-2 | Reduced phagocytosis and ROS production | |
| Enzymatic detoxification | SodA | Superoxide resistance |
| AhpC | H2O2 resistance | |
| GpoA | Superoxide resistance | |
| NoxA | Superoxide resistance and H2O2 resistance | |
| Enzymatic repair | HtrA | Protein repair upon ROS damage |
| PolA1 | DNA repair upon ROS damage, H2O2 resistance and inhibition of Fenton reaction | |
| Metal ion binding | PmtA | Metal transporter and H2O2 resistance |
| Dpr | Iron sequestration and H2O2 resistance | |
| MtsABC | Metal transporter, superoxide and H2O2 resistance, inhibition of Fenton reaction | |
| Shr | Iron sequestration and H2O2 resistance |
| Resistance mechanism . | GAS factor . | Function . |
|---|---|---|
| Surface/secreted protein | M protein | Impaired fusion of azurophilic granules with phagolysosome |
| HA capsule | H2O2 resistance by aggregation | |
| Mac-1 | Reduced phagocytosis and ROS production | |
| Mac-2 | Reduced phagocytosis and ROS production | |
| Enzymatic detoxification | SodA | Superoxide resistance |
| AhpC | H2O2 resistance | |
| GpoA | Superoxide resistance | |
| NoxA | Superoxide resistance and H2O2 resistance | |
| Enzymatic repair | HtrA | Protein repair upon ROS damage |
| PolA1 | DNA repair upon ROS damage, H2O2 resistance and inhibition of Fenton reaction | |
| Metal ion binding | PmtA | Metal transporter and H2O2 resistance |
| Dpr | Iron sequestration and H2O2 resistance | |
| MtsABC | Metal transporter, superoxide and H2O2 resistance, inhibition of Fenton reaction | |
| Shr | Iron sequestration and H2O2 resistance |
| Resistance mechanism . | GAS factor . | Function . |
|---|---|---|
| Surface/secreted protein | M protein | Impaired fusion of azurophilic granules with phagolysosome |
| HA capsule | H2O2 resistance by aggregation | |
| Mac-1 | Reduced phagocytosis and ROS production | |
| Mac-2 | Reduced phagocytosis and ROS production | |
| Enzymatic detoxification | SodA | Superoxide resistance |
| AhpC | H2O2 resistance | |
| GpoA | Superoxide resistance | |
| NoxA | Superoxide resistance and H2O2 resistance | |
| Enzymatic repair | HtrA | Protein repair upon ROS damage |
| PolA1 | DNA repair upon ROS damage, H2O2 resistance and inhibition of Fenton reaction | |
| Metal ion binding | PmtA | Metal transporter and H2O2 resistance |
| Dpr | Iron sequestration and H2O2 resistance | |
| MtsABC | Metal transporter, superoxide and H2O2 resistance, inhibition of Fenton reaction | |
| Shr | Iron sequestration and H2O2 resistance |
| Resistance mechanism . | GAS factor . | Function . |
|---|---|---|
| Surface/secreted protein | M protein | Impaired fusion of azurophilic granules with phagolysosome |
| HA capsule | H2O2 resistance by aggregation | |
| Mac-1 | Reduced phagocytosis and ROS production | |
| Mac-2 | Reduced phagocytosis and ROS production | |
| Enzymatic detoxification | SodA | Superoxide resistance |
| AhpC | H2O2 resistance | |
| GpoA | Superoxide resistance | |
| NoxA | Superoxide resistance and H2O2 resistance | |
| Enzymatic repair | HtrA | Protein repair upon ROS damage |
| PolA1 | DNA repair upon ROS damage, H2O2 resistance and inhibition of Fenton reaction | |
| Metal ion binding | PmtA | Metal transporter and H2O2 resistance |
| Dpr | Iron sequestration and H2O2 resistance | |
| MtsABC | Metal transporter, superoxide and H2O2 resistance, inhibition of Fenton reaction | |
| Shr | Iron sequestration and H2O2 resistance |
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