Association of Serum Cytokines/Chemokines With T1D in the Confirmation Dataset (1553 T1D Patients and 1493 Control Subjects)
| Protein Levels as Continuous Variable . | Protein Levels as Categorical Variable . | |||||||
|---|---|---|---|---|---|---|---|---|
| Quartile 2 . | Quartile 3 . | Quartile 4 . | ||||||
| Protein . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . |
| IL8 | 0.43 (0.37–0.49) | 8.86 × 10−32 | 0.92 (0.72–1.18) | NS | 0.44 (0.33–0.57) | 7 × 10−9 | 0.09 (0.06–0.14) | 2 × 10−27 |
| IL-1Ra | 0.56 (0.51–0.62) | 3.78 × 10−27 | 0.92 (0.74–1.15) | NS | 0.84 (0.67–1.05) | NS | 0.18 (0.14–0.25) | 1 × 10−26 |
| MCP-1 | 0.61 (0.55–0.69) | 4.33 × 10−17 | 0.88 (0.71–1.10) | NS | 0.83 (0.66–1.05) | NS | 0.38 (0.29–0.49) | 8 × 10−13 |
| MIP-1β | 0.69 (0.62–0.76) | 2.43 × 10−13 | 1.06 (0.83–1.34) | NS | 0.92 (0.72–1.17) | NS | 0.44 (0.33–0.58) | 3 × 10−9 |
| Protein Levels as Continuous Variable . | Protein Levels as Categorical Variable . | |||||||
|---|---|---|---|---|---|---|---|---|
| Quartile 2 . | Quartile 3 . | Quartile 4 . | ||||||
| Protein . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . |
| IL8 | 0.43 (0.37–0.49) | 8.86 × 10−32 | 0.92 (0.72–1.18) | NS | 0.44 (0.33–0.57) | 7 × 10−9 | 0.09 (0.06–0.14) | 2 × 10−27 |
| IL-1Ra | 0.56 (0.51–0.62) | 3.78 × 10−27 | 0.92 (0.74–1.15) | NS | 0.84 (0.67–1.05) | NS | 0.18 (0.14–0.25) | 1 × 10−26 |
| MCP-1 | 0.61 (0.55–0.69) | 4.33 × 10−17 | 0.88 (0.71–1.10) | NS | 0.83 (0.66–1.05) | NS | 0.38 (0.29–0.49) | 8 × 10−13 |
| MIP-1β | 0.69 (0.62–0.76) | 2.43 × 10−13 | 1.06 (0.83–1.34) | NS | 0.92 (0.72–1.17) | NS | 0.44 (0.33–0.58) | 3 × 10−9 |
Abbreviation: NS, Not significant.
First quartile was used as a reference.
Association of Serum Cytokines/Chemokines With T1D in the Confirmation Dataset (1553 T1D Patients and 1493 Control Subjects)
| Protein Levels as Continuous Variable . | Protein Levels as Categorical Variable . | |||||||
|---|---|---|---|---|---|---|---|---|
| Quartile 2 . | Quartile 3 . | Quartile 4 . | ||||||
| Protein . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . |
| IL8 | 0.43 (0.37–0.49) | 8.86 × 10−32 | 0.92 (0.72–1.18) | NS | 0.44 (0.33–0.57) | 7 × 10−9 | 0.09 (0.06–0.14) | 2 × 10−27 |
| IL-1Ra | 0.56 (0.51–0.62) | 3.78 × 10−27 | 0.92 (0.74–1.15) | NS | 0.84 (0.67–1.05) | NS | 0.18 (0.14–0.25) | 1 × 10−26 |
| MCP-1 | 0.61 (0.55–0.69) | 4.33 × 10−17 | 0.88 (0.71–1.10) | NS | 0.83 (0.66–1.05) | NS | 0.38 (0.29–0.49) | 8 × 10−13 |
| MIP-1β | 0.69 (0.62–0.76) | 2.43 × 10−13 | 1.06 (0.83–1.34) | NS | 0.92 (0.72–1.17) | NS | 0.44 (0.33–0.58) | 3 × 10−9 |
| Protein Levels as Continuous Variable . | Protein Levels as Categorical Variable . | |||||||
|---|---|---|---|---|---|---|---|---|
| Quartile 2 . | Quartile 3 . | Quartile 4 . | ||||||
| Protein . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . | OR (95% CI) . | Adj P . |
| IL8 | 0.43 (0.37–0.49) | 8.86 × 10−32 | 0.92 (0.72–1.18) | NS | 0.44 (0.33–0.57) | 7 × 10−9 | 0.09 (0.06–0.14) | 2 × 10−27 |
| IL-1Ra | 0.56 (0.51–0.62) | 3.78 × 10−27 | 0.92 (0.74–1.15) | NS | 0.84 (0.67–1.05) | NS | 0.18 (0.14–0.25) | 1 × 10−26 |
| MCP-1 | 0.61 (0.55–0.69) | 4.33 × 10−17 | 0.88 (0.71–1.10) | NS | 0.83 (0.66–1.05) | NS | 0.38 (0.29–0.49) | 8 × 10−13 |
| MIP-1β | 0.69 (0.62–0.76) | 2.43 × 10−13 | 1.06 (0.83–1.34) | NS | 0.92 (0.72–1.17) | NS | 0.44 (0.33–0.58) | 3 × 10−9 |
Abbreviation: NS, Not significant.
First quartile was used as a reference.
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