Table 1.
Open in new tab

Research Laboratory Results of Cases Who Had an Amniocentesis to Rule Out Intraamniotic Infection (n = 129)

Variables(−) AFC and Intact and TD n = 28(−) AFC and Intact and PTB n = 20(−) AFC and PPROM and PTB n = 20(+) AFC and Intact & PTB n = 28(+) AFC and PPROM and PTBn = 33P Value
Intraamniotic inflammation
    Absent (MR = 0)18131201<.001
    Mild (MR = 1 or 2)107805
    Severe (MR = 3 or 4)0002827
IL-6, ng/mLa0.2 [0.1–0.2]0.7 [0.2–2.1]0.5 [0.2–1.0]85.4 [31.9–122.9]17.1 [9.0–42.5]<.001
Activin A, ng/mLa7.8 [5.3–10.4]9.2 [6.0–11.2]5.9 [4.6–9.0]18.1 [12.9–25.6]13.1 [7.7–22.7]<.001
Follistatin, ng/mLa3.2 [2.2–6.0]4.0 [2.1–6.2]3.1 [2.3–4.2]3.4 [2.3–5.5]2.8 [1.8–4.2].578
Activin A to follistatin ratio†2.9 [1.9–5.1]3.0 [2.2–5.3]2.4 [1.9–5.0]7.0 [4.1–11.7]5.7 [3.6–16.2]<.001
Variables(−) AFC and Intact and TD n = 28(−) AFC and Intact and PTB n = 20(−) AFC and PPROM and PTB n = 20(+) AFC and Intact & PTB n = 28(+) AFC and PPROM and PTBn = 33P Value
Intraamniotic inflammation
    Absent (MR = 0)18131201<.001
    Mild (MR = 1 or 2)107805
    Severe (MR = 3 or 4)0002827
IL-6, ng/mLa0.2 [0.1–0.2]0.7 [0.2–2.1]0.5 [0.2–1.0]85.4 [31.9–122.9]17.1 [9.0–42.5]<.001
Activin A, ng/mLa7.8 [5.3–10.4]9.2 [6.0–11.2]5.9 [4.6–9.0]18.1 [12.9–25.6]13.1 [7.7–22.7]<.001
Follistatin, ng/mLa3.2 [2.2–6.0]4.0 [2.1–6.2]3.1 [2.3–4.2]3.4 [2.3–5.5]2.8 [1.8–4.2].578
Activin A to follistatin ratio†2.9 [1.9–5.1]3.0 [2.2–5.3]2.4 [1.9–5.0]7.0 [4.1–11.7]5.7 [3.6–16.2]<.001

Intraamniotic inflammation was assessed by proteomics analysis of AF and the MR score.

a

Data are presented as median [interquartile range] and analyzed by a Kruskal-Wallis one-way ANOVA.

Table 1.
Open in new tab

Research Laboratory Results of Cases Who Had an Amniocentesis to Rule Out Intraamniotic Infection (n = 129)

Variables(−) AFC and Intact and TD n = 28(−) AFC and Intact and PTB n = 20(−) AFC and PPROM and PTB n = 20(+) AFC and Intact & PTB n = 28(+) AFC and PPROM and PTBn = 33P Value
Intraamniotic inflammation
    Absent (MR = 0)18131201<.001
    Mild (MR = 1 or 2)107805
    Severe (MR = 3 or 4)0002827
IL-6, ng/mLa0.2 [0.1–0.2]0.7 [0.2–2.1]0.5 [0.2–1.0]85.4 [31.9–122.9]17.1 [9.0–42.5]<.001
Activin A, ng/mLa7.8 [5.3–10.4]9.2 [6.0–11.2]5.9 [4.6–9.0]18.1 [12.9–25.6]13.1 [7.7–22.7]<.001
Follistatin, ng/mLa3.2 [2.2–6.0]4.0 [2.1–6.2]3.1 [2.3–4.2]3.4 [2.3–5.5]2.8 [1.8–4.2].578
Activin A to follistatin ratio†2.9 [1.9–5.1]3.0 [2.2–5.3]2.4 [1.9–5.0]7.0 [4.1–11.7]5.7 [3.6–16.2]<.001
Variables(−) AFC and Intact and TD n = 28(−) AFC and Intact and PTB n = 20(−) AFC and PPROM and PTB n = 20(+) AFC and Intact & PTB n = 28(+) AFC and PPROM and PTBn = 33P Value
Intraamniotic inflammation
    Absent (MR = 0)18131201<.001
    Mild (MR = 1 or 2)107805
    Severe (MR = 3 or 4)0002827
IL-6, ng/mLa0.2 [0.1–0.2]0.7 [0.2–2.1]0.5 [0.2–1.0]85.4 [31.9–122.9]17.1 [9.0–42.5]<.001
Activin A, ng/mLa7.8 [5.3–10.4]9.2 [6.0–11.2]5.9 [4.6–9.0]18.1 [12.9–25.6]13.1 [7.7–22.7]<.001
Follistatin, ng/mLa3.2 [2.2–6.0]4.0 [2.1–6.2]3.1 [2.3–4.2]3.4 [2.3–5.5]2.8 [1.8–4.2].578
Activin A to follistatin ratio†2.9 [1.9–5.1]3.0 [2.2–5.3]2.4 [1.9–5.0]7.0 [4.1–11.7]5.7 [3.6–16.2]<.001

Intraamniotic inflammation was assessed by proteomics analysis of AF and the MR score.

a

Data are presented as median [interquartile range] and analyzed by a Kruskal-Wallis one-way ANOVA.

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