Table 2. Open in new tab Biodistribution...

	10 Minutes	30 Minutes	60 Minutes
Tissue distribution (percentage of the injected dose per gram of tissue)
Blood	1.40 ± 0.13	0.08 ± 0.01	2.55 ± 0.16^a	0.08 ± 0.01	2.91 ± 0.09^a	0.09 ± 0.01
Whole brain	0.30 ± 0.02	0.01 ± 0.00	0.18 ± 0.02^a	0.01 ± 0.00	0.11 ± 0.00^a,^b	0.02 ± 0.00
Heart	0.48 ± 0.07	0.29 ± 0.07	0.74 ± 0.03^a	0.25 ± 0.06	0.77 ± 0.03^a	0.25 ± 0.03^a
Lungs	0.72 ± 0.05	0.60 ± 0.08	0.90 ± 0.09	0.39 ± 0.06^a	1.01 ± 0.03^a	0.43 ± 0.05^a
Stomach	0.52 ± 0.18	0.58 ± 0.16	0.46 ± 0.11	0.74 ± 0.08	0.41 ± 0.05	1.06 ± 0.22^a,^b
Liver	3.29 ± 0.08	5.58 ± 1.07	1.82 ± 0.04^a	5.90 ± 0.72	1.37 ± 0.06^a,^b	4.13 ± 0.83^b
Spleen	0.30 ± 0.02	3.65 ± 0.35	0.43 ± 0.04^a	4.05 ± 1.26	0.39 ± 0.03	3.92 ± 1.07
Sm. intestine	0.62 ± 0.03	1.05 ± 0.11	0.68 ± 0.06	1.87 ± 0.18^a	0.79 ± 0.11	2.98 ± 0.38^a,^b
Lg. intestine	0.10 ± 0.02	0.16 ± 0.02	0.12 ± 0.01	0.21 ± 0.02	0.14 ± 0.02	0.46 ± 0.23^a
Kidneys	0.70 ± 0.01	1.70 ± 0.47	1.10 ± 0.12^a	1.09 ± 0.19^a	1.10 ± 0.10^a	1.06 ± 0.13^a
Bladder, including urine	0.25 ± 0.27	0.24 ± 0.09	0.39 ± 0.08	1.19 ± 0.97	0.68 ± 0.30	2.16 ± 1.06^a
Muscle	0.18 ± 0.05	0.26 ± 0.27	0.18 ± 0.02	0.10 ± 0.01	0.16 ± 0.02	0.09 ± 0.01
Adrenal glands	22.14 ± 6.98	9.24 ± 1.45	17.66 ± 7.43	20.28 ± 4.23^a	19.70 ± 8.14	20.40 ± 6.35^a
Testes	0.52 ± 0.08	0.05 ± 0.01	0.32 ± 0.04^a	0.06 ± 0.03	0.33 ± 0.02^a	0.08 ± 0.01^a,^b
Carcass	0.29 ± 0.00	0.21 ± 0.03	0.31 ± 0.03	0.16 ± 0.01	0.34 ± 0.01	0.18 ± 0.03
Thyroids	1.30 ± 1.05	—	0.81 ± 0.16	—	1.29 ± 0.25	—
Thighbones	—	0.61 ± 0.07	—	0.59 ± 0.05	—	0.70 ± 0.10
Tissue distribution ratios relative to adrenal gland
Adrenal gland/blood	15.93 ± 4.94	126.00 ± 32.86	6.84 ± 2.49	258.85 ± 54.92^a	6.73 ± 2.57	236.62 ± 77.01
Adrenal gland/liver	6.72 ± 2.00	1.70 ± 0.38	9.74 ± 4.16	3.48 ± 0.80	14.20 ± 5.28	4.94 ± 1.41^a
Adrenal gland/kidney	31.76 ± 10.16	5.66 ± 1.31	16.66 ± 8.95	18.89 ± 4.50^a	18.20 ± 8.58	19.20 ± 6.01^a
Adrenal gland/Sm. intestine	35.65 ± 9.43	8.81 ± 1.41	25.49 ± 8.31	10.83 ± 1.77	24.59 ± 8.26	7.00 ± 2.62

10 Minutes

30 Minutes

60 Minutes

I-IMTO

^rF-CDP2230

I-IMTO

^rF-CDP2230

I-IMTO

^rF-CDP2230

Tissue distribution (percentage of the injected dose per gram of tissue)

Blood

1.40 ± 0.13

0.08 ± 0.01

2.55 ± 0.16^a

0.08 ± 0.01

2.91 ± 0.09^a

0.09 ± 0.01

Whole brain

0.30 ± 0.02

0.01 ± 0.00

0.18 ± 0.02^a

0.01 ± 0.00

0.11 ± 0.00^a,^b

0.02 ± 0.00

Heart

0.48 ± 0.07

0.29 ± 0.07

0.74 ± 0.03^a

0.25 ± 0.06

0.77 ± 0.03^a

0.25 ± 0.03^a

Lungs

0.72 ± 0.05

0.60 ± 0.08

0.90 ± 0.09

0.39 ± 0.06^a

1.01 ± 0.03^a

0.43 ± 0.05^a

Stomach

0.52 ± 0.18

0.58 ± 0.16

0.46 ± 0.11

0.74 ± 0.08

0.41 ± 0.05

1.06 ± 0.22^a,^b

Liver

3.29 ± 0.08

5.58 ± 1.07

1.82 ± 0.04^a

5.90 ± 0.72

1.37 ± 0.06^a,^b

4.13 ± 0.83^b

Spleen

0.30 ± 0.02

3.65 ± 0.35

0.43 ± 0.04^a

4.05 ± 1.26

0.39 ± 0.03

3.92 ± 1.07

Sm. intestine

0.62 ± 0.03

1.05 ± 0.11

0.68 ± 0.06

1.87 ± 0.18^a

0.79 ± 0.11

2.98 ± 0.38^a,^b

Lg. intestine

0.10 ± 0.02

0.16 ± 0.02

0.12 ± 0.01

0.21 ± 0.02

0.14 ± 0.02

0.46 ± 0.23^a

Kidneys

0.70 ± 0.01

1.70 ± 0.47

1.10 ± 0.12^a

1.09 ± 0.19^a

1.10 ± 0.10^a

1.06 ± 0.13^a

Bladder, including urine

0.25 ± 0.27

0.24 ± 0.09

0.39 ± 0.08

1.19 ± 0.97

0.68 ± 0.30

2.16 ± 1.06^a

Muscle

0.18 ± 0.05

0.26 ± 0.27

0.18 ± 0.02

0.10 ± 0.01

0.16 ± 0.02

0.09 ± 0.01

Adrenal glands

22.14 ± 6.98

9.24 ± 1.45

17.66 ± 7.43

20.28 ± 4.23^a

19.70 ± 8.14

20.40 ± 6.35^a

Testes

0.52 ± 0.08

0.05 ± 0.01

0.32 ± 0.04^a

0.06 ± 0.03

0.33 ± 0.02^a

0.08 ± 0.01^a,^b

Carcass

0.29 ± 0.00

0.21 ± 0.03

0.31 ± 0.03

0.16 ± 0.01

0.34 ± 0.01

0.18 ± 0.03

Thyroids

1.30 ± 1.05

—

0.81 ± 0.16

—

1.29 ± 0.25

—

Thighbones

—

0.61 ± 0.07

—

0.59 ± 0.05

—

0.70 ± 0.10

Tissue distribution ratios relative to adrenal gland

Adrenal gland/blood

15.93 ± 4.94

126.00 ± 32.86

6.84 ± 2.49

258.85 ± 54.92^a

6.73 ± 2.57

236.62 ± 77.01

Adrenal gland/liver

6.72 ± 2.00

1.70 ± 0.38

9.74 ± 4.16

3.48 ± 0.80

14.20 ± 5.28

4.94 ± 1.41^a

Adrenal gland/kidney

31.76 ± 10.16

5.66 ± 1.31

16.66 ± 8.95

18.89 ± 4.50^a

18.20 ± 8.58

19.20 ± 6.01^a

Adrenal gland/Sm. intestine

35.65 ± 9.43

8.81 ± 1.41

25.49 ± 8.31

10.83 ± 1.77

24.59 ± 8.26

7.00 ± 2.62

	10 Minutes	30 Minutes	60 Minutes
Tissue distribution (percentage of the injected dose per gram of tissue)
Blood	1.40 ± 0.13	0.08 ± 0.01	2.55 ± 0.16^a	0.08 ± 0.01	2.91 ± 0.09^a	0.09 ± 0.01
Whole brain	0.30 ± 0.02	0.01 ± 0.00	0.18 ± 0.02^a	0.01 ± 0.00	0.11 ± 0.00^a,^b	0.02 ± 0.00
Heart	0.48 ± 0.07	0.29 ± 0.07	0.74 ± 0.03^a	0.25 ± 0.06	0.77 ± 0.03^a	0.25 ± 0.03^a
Lungs	0.72 ± 0.05	0.60 ± 0.08	0.90 ± 0.09	0.39 ± 0.06^a	1.01 ± 0.03^a	0.43 ± 0.05^a
Stomach	0.52 ± 0.18	0.58 ± 0.16	0.46 ± 0.11	0.74 ± 0.08	0.41 ± 0.05	1.06 ± 0.22^a,^b
Liver	3.29 ± 0.08	5.58 ± 1.07	1.82 ± 0.04^a	5.90 ± 0.72	1.37 ± 0.06^a,^b	4.13 ± 0.83^b
Spleen	0.30 ± 0.02	3.65 ± 0.35	0.43 ± 0.04^a	4.05 ± 1.26	0.39 ± 0.03	3.92 ± 1.07
Sm. intestine	0.62 ± 0.03	1.05 ± 0.11	0.68 ± 0.06	1.87 ± 0.18^a	0.79 ± 0.11	2.98 ± 0.38^a,^b
Lg. intestine	0.10 ± 0.02	0.16 ± 0.02	0.12 ± 0.01	0.21 ± 0.02	0.14 ± 0.02	0.46 ± 0.23^a
Kidneys	0.70 ± 0.01	1.70 ± 0.47	1.10 ± 0.12^a	1.09 ± 0.19^a	1.10 ± 0.10^a	1.06 ± 0.13^a
Bladder, including urine	0.25 ± 0.27	0.24 ± 0.09	0.39 ± 0.08	1.19 ± 0.97	0.68 ± 0.30	2.16 ± 1.06^a
Muscle	0.18 ± 0.05	0.26 ± 0.27	0.18 ± 0.02	0.10 ± 0.01	0.16 ± 0.02	0.09 ± 0.01
Adrenal glands	22.14 ± 6.98	9.24 ± 1.45	17.66 ± 7.43	20.28 ± 4.23^a	19.70 ± 8.14	20.40 ± 6.35^a
Testes	0.52 ± 0.08	0.05 ± 0.01	0.32 ± 0.04^a	0.06 ± 0.03	0.33 ± 0.02^a	0.08 ± 0.01^a,^b
Carcass	0.29 ± 0.00	0.21 ± 0.03	0.31 ± 0.03	0.16 ± 0.01	0.34 ± 0.01	0.18 ± 0.03
Thyroids	1.30 ± 1.05	—	0.81 ± 0.16	—	1.29 ± 0.25	—
Thighbones	—	0.61 ± 0.07	—	0.59 ± 0.05	—	0.70 ± 0.10
Tissue distribution ratios relative to adrenal gland
Adrenal gland/blood	15.93 ± 4.94	126.00 ± 32.86	6.84 ± 2.49	258.85 ± 54.92^a	6.73 ± 2.57	236.62 ± 77.01
Adrenal gland/liver	6.72 ± 2.00	1.70 ± 0.38	9.74 ± 4.16	3.48 ± 0.80	14.20 ± 5.28	4.94 ± 1.41^a
Adrenal gland/kidney	31.76 ± 10.16	5.66 ± 1.31	16.66 ± 8.95	18.89 ± 4.50^a	18.20 ± 8.58	19.20 ± 6.01^a
Adrenal gland/Sm. intestine	35.65 ± 9.43	8.81 ± 1.41	25.49 ± 8.31	10.83 ± 1.77	24.59 ± 8.26	7.00 ± 2.62

Table 2.

Open in new tab

Biodistribution of I-IMTO and ^rF-CDP2230 in Rats at 10, 30, and 60 Minutes After Injection

	10 Minutes		30 Minutes		60 Minutes
	I-IMTO	^rF-CDP2230	I-IMTO	^rF-CDP2230	I-IMTO	^rF-CDP2230
Tissue distribution (percentage of the injected dose per gram of tissue)
Blood	1.40 ± 0.13	0.08 ± 0.01	2.55 ± 0.16^a	0.08 ± 0.01	2.91 ± 0.09^a	0.09 ± 0.01
Whole brain	0.30 ± 0.02	0.01 ± 0.00	0.18 ± 0.02^a	0.01 ± 0.00	0.11 ± 0.00^a,^b	0.02 ± 0.00
Heart	0.48 ± 0.07	0.29 ± 0.07	0.74 ± 0.03^a	0.25 ± 0.06	0.77 ± 0.03^a	0.25 ± 0.03^a
Lungs	0.72 ± 0.05	0.60 ± 0.08	0.90 ± 0.09	0.39 ± 0.06^a	1.01 ± 0.03^a	0.43 ± 0.05^a
Stomach	0.52 ± 0.18	0.58 ± 0.16	0.46 ± 0.11	0.74 ± 0.08	0.41 ± 0.05	1.06 ± 0.22^a,^b
Liver	3.29 ± 0.08	5.58 ± 1.07	1.82 ± 0.04^a	5.90 ± 0.72	1.37 ± 0.06^a,^b	4.13 ± 0.83^b
Spleen	0.30 ± 0.02	3.65 ± 0.35	0.43 ± 0.04^a	4.05 ± 1.26	0.39 ± 0.03	3.92 ± 1.07
Sm. intestine	0.62 ± 0.03	1.05 ± 0.11	0.68 ± 0.06	1.87 ± 0.18^a	0.79 ± 0.11	2.98 ± 0.38^a,^b
Lg. intestine	0.10 ± 0.02	0.16 ± 0.02	0.12 ± 0.01	0.21 ± 0.02	0.14 ± 0.02	0.46 ± 0.23^a
Kidneys	0.70 ± 0.01	1.70 ± 0.47	1.10 ± 0.12^a	1.09 ± 0.19^a	1.10 ± 0.10^a	1.06 ± 0.13^a
Bladder, including urine	0.25 ± 0.27	0.24 ± 0.09	0.39 ± 0.08	1.19 ± 0.97	0.68 ± 0.30	2.16 ± 1.06^a
Muscle	0.18 ± 0.05	0.26 ± 0.27	0.18 ± 0.02	0.10 ± 0.01	0.16 ± 0.02	0.09 ± 0.01
Adrenal glands	22.14 ± 6.98	9.24 ± 1.45	17.66 ± 7.43	20.28 ± 4.23^a	19.70 ± 8.14	20.40 ± 6.35^a
Testes	0.52 ± 0.08	0.05 ± 0.01	0.32 ± 0.04^a	0.06 ± 0.03	0.33 ± 0.02^a	0.08 ± 0.01^a,^b
Carcass	0.29 ± 0.00	0.21 ± 0.03	0.31 ± 0.03	0.16 ± 0.01	0.34 ± 0.01	0.18 ± 0.03
Thyroids	1.30 ± 1.05	—	0.81 ± 0.16	—	1.29 ± 0.25	—
Thighbones	—	0.61 ± 0.07	—	0.59 ± 0.05	—	0.70 ± 0.10
Tissue distribution ratios relative to adrenal gland
Adrenal gland/blood	15.93 ± 4.94	126.00 ± 32.86	6.84 ± 2.49	258.85 ± 54.92^a	6.73 ± 2.57	236.62 ± 77.01
Adrenal gland/liver	6.72 ± 2.00	1.70 ± 0.38	9.74 ± 4.16	3.48 ± 0.80	14.20 ± 5.28	4.94 ± 1.41^a
Adrenal gland/kidney	31.76 ± 10.16	5.66 ± 1.31	16.66 ± 8.95	18.89 ± 4.50^a	18.20 ± 8.58	19.20 ± 6.01^a
Adrenal gland/Sm. intestine	35.65 ± 9.43	8.81 ± 1.41	25.49 ± 8.31	10.83 ± 1.77	24.59 ± 8.26	7.00 ± 2.62

	10 Minutes		30 Minutes		60 Minutes
	I-IMTO	^rF-CDP2230	I-IMTO	^rF-CDP2230	I-IMTO	^rF-CDP2230
Tissue distribution (percentage of the injected dose per gram of tissue)
Blood	1.40 ± 0.13	0.08 ± 0.01	2.55 ± 0.16^a	0.08 ± 0.01	2.91 ± 0.09^a	0.09 ± 0.01
Whole brain	0.30 ± 0.02	0.01 ± 0.00	0.18 ± 0.02^a	0.01 ± 0.00	0.11 ± 0.00^a,^b	0.02 ± 0.00
Heart	0.48 ± 0.07	0.29 ± 0.07	0.74 ± 0.03^a	0.25 ± 0.06	0.77 ± 0.03^a	0.25 ± 0.03^a
Lungs	0.72 ± 0.05	0.60 ± 0.08	0.90 ± 0.09	0.39 ± 0.06^a	1.01 ± 0.03^a	0.43 ± 0.05^a
Stomach	0.52 ± 0.18	0.58 ± 0.16	0.46 ± 0.11	0.74 ± 0.08	0.41 ± 0.05	1.06 ± 0.22^a,^b
Liver	3.29 ± 0.08	5.58 ± 1.07	1.82 ± 0.04^a	5.90 ± 0.72	1.37 ± 0.06^a,^b	4.13 ± 0.83^b
Spleen	0.30 ± 0.02	3.65 ± 0.35	0.43 ± 0.04^a	4.05 ± 1.26	0.39 ± 0.03	3.92 ± 1.07
Sm. intestine	0.62 ± 0.03	1.05 ± 0.11	0.68 ± 0.06	1.87 ± 0.18^a	0.79 ± 0.11	2.98 ± 0.38^a,^b
Lg. intestine	0.10 ± 0.02	0.16 ± 0.02	0.12 ± 0.01	0.21 ± 0.02	0.14 ± 0.02	0.46 ± 0.23^a
Kidneys	0.70 ± 0.01	1.70 ± 0.47	1.10 ± 0.12^a	1.09 ± 0.19^a	1.10 ± 0.10^a	1.06 ± 0.13^a
Bladder, including urine	0.25 ± 0.27	0.24 ± 0.09	0.39 ± 0.08	1.19 ± 0.97	0.68 ± 0.30	2.16 ± 1.06^a
Muscle	0.18 ± 0.05	0.26 ± 0.27	0.18 ± 0.02	0.10 ± 0.01	0.16 ± 0.02	0.09 ± 0.01
Adrenal glands	22.14 ± 6.98	9.24 ± 1.45	17.66 ± 7.43	20.28 ± 4.23^a	19.70 ± 8.14	20.40 ± 6.35^a
Testes	0.52 ± 0.08	0.05 ± 0.01	0.32 ± 0.04^a	0.06 ± 0.03	0.33 ± 0.02^a	0.08 ± 0.01^a,^b
Carcass	0.29 ± 0.00	0.21 ± 0.03	0.31 ± 0.03	0.16 ± 0.01	0.34 ± 0.01	0.18 ± 0.03
Thyroids	1.30 ± 1.05	—	0.81 ± 0.16	—	1.29 ± 0.25	—
Thighbones	—	0.61 ± 0.07	—	0.59 ± 0.05	—	0.70 ± 0.10
Tissue distribution ratios relative to adrenal gland
Adrenal gland/blood	15.93 ± 4.94	126.00 ± 32.86	6.84 ± 2.49	258.85 ± 54.92^a	6.73 ± 2.57	236.62 ± 77.01
Adrenal gland/liver	6.72 ± 2.00	1.70 ± 0.38	9.74 ± 4.16	3.48 ± 0.80	14.20 ± 5.28	4.94 ± 1.41^a
Adrenal gland/kidney	31.76 ± 10.16	5.66 ± 1.31	16.66 ± 8.95	18.89 ± 4.50^a	18.20 ± 8.58	19.20 ± 6.01^a
Adrenal gland/Sm. intestine	35.65 ± 9.43	8.81 ± 1.41	25.49 ± 8.31	10.83 ± 1.77	24.59 ± 8.26	7.00 ± 2.62

The results are expressed as the mean ± SD of 3–6 independent experiments.

Significantly different from the value at 10 minutes (P < .01).

Significantly different from the value at 30 minutes (P < .01).

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