Table 1. Open in new tab IC 50 for...

Table 1.

IC₅₀ for CYP11B2 and CYP11B1 Activity

Compound	IC₅₀ for CYP11B2 (nM)	IC₅₀ for CYP11B1 (nM)	Selectivity Factor^a
MTO	0.59 ± 0.64^b	0.24 ± 0.05^b	0.41
IMTO	0.24 ± 0.14^b	0.28 ± 0.22^b	1.16
CDP2230	6.90 ± 2.93	109 ± 5.99	15.8

Compound	IC₅₀ for CYP11B2 (nM)	IC₅₀ for CYP11B1 (nM)	Selectivity Factor^a
MTO	0.59 ± 0.64^b	0.24 ± 0.05^b	0.41
IMTO	0.24 ± 0.14^b	0.28 ± 0.22^b	1.16
CDP2230	6.90 ± 2.93	109 ± 5.99	15.8

The results are expressed as the mean ± SD of 3–6 independent experiments.

IC₅₀ for CYP11B1/IC₅₀ for CYP11B2.

Significantly different from the value for CDP2230 (P < .01).