Profile of TSHR Antibodies to Active and Inactive A-Subunits Observed in Different Conditions
| Condition . | Active (Pathogenic) . | Inactive . | Reference . |
|---|---|---|---|
| Graves' disease (humans) | Yes | No | (5, 9) |
| TSHR A-subunit cDNA in vivo immunization (mice) | Yes | Yes | (10, 12–14) |
| Spontaneous TSHR antibodies (NOD/TSHR mice) | Yes | Yes | (15) |
| TSHR protein plus adjuvant immunization (mice) | No | Yes | (16) |
| Condition . | Active (Pathogenic) . | Inactive . | Reference . |
|---|---|---|---|
| Graves' disease (humans) | Yes | No | (5, 9) |
| TSHR A-subunit cDNA in vivo immunization (mice) | Yes | Yes | (10, 12–14) |
| Spontaneous TSHR antibodies (NOD/TSHR mice) | Yes | Yes | (15) |
| TSHR protein plus adjuvant immunization (mice) | No | Yes | (16) |
Profile of TSHR Antibodies to Active and Inactive A-Subunits Observed in Different Conditions
| Condition . | Active (Pathogenic) . | Inactive . | Reference . |
|---|---|---|---|
| Graves' disease (humans) | Yes | No | (5, 9) |
| TSHR A-subunit cDNA in vivo immunization (mice) | Yes | Yes | (10, 12–14) |
| Spontaneous TSHR antibodies (NOD/TSHR mice) | Yes | Yes | (15) |
| TSHR protein plus adjuvant immunization (mice) | No | Yes | (16) |
| Condition . | Active (Pathogenic) . | Inactive . | Reference . |
|---|---|---|---|
| Graves' disease (humans) | Yes | No | (5, 9) |
| TSHR A-subunit cDNA in vivo immunization (mice) | Yes | Yes | (10, 12–14) |
| Spontaneous TSHR antibodies (NOD/TSHR mice) | Yes | Yes | (15) |
| TSHR protein plus adjuvant immunization (mice) | No | Yes | (16) |
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