Table 2.

Cross-Sectional Studies Evaluating the Relationship Between BMF and BMD in Osteoporotic Populations

StudyPopulationAdiposity MeasureBone ParametersResultsAdjustment
Griffith et al, 2005 (31)82 men (67–101 y)Vertebral BMF content by MRS Vertebral BMF perfusion (average maximum enhancement) Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 42) Osteopenic (n = 23); osteoporotic (n = 17)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Yeung et al, 2005 (32)50 postmenopausal women (66–81 years of age) and 12 controls (18–43 years)Vertebral BMF content by MRS Vertebral BMF composition by MRS Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 15), osteopenic (n = 15), osteoporotic (n = 20), and controls (n = 12)BMF content↗ and fat unsaturation index ↘ 1/osteoporotic vs normal 2/osteopenic vs normal 3/osteoporotic vs controlsAge-matched
Tang et al, 2010 (55)78 postmenopausal women (55–81 years of age)Vertebral BMF content by MRS Vertebral BMF perfusion Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 24), osteopenic (n = 25), and osteoporotic (n = 29)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Li et al, 2011 (21)51 postmenopausal women (54–73 years of age)Vertebral BMF content by MRS Anatomic site: L1–L4 MRI: 3 TeslaVertebral BMD (DXA) Normal (n = 13), osteopenic/osteoporotic (n = 38)BMF content↗ 1/osteopenic/osteoporotic versus normalAge and body mass index
StudyPopulationAdiposity MeasureBone ParametersResultsAdjustment
Griffith et al, 2005 (31)82 men (67–101 y)Vertebral BMF content by MRS Vertebral BMF perfusion (average maximum enhancement) Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 42) Osteopenic (n = 23); osteoporotic (n = 17)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Yeung et al, 2005 (32)50 postmenopausal women (66–81 years of age) and 12 controls (18–43 years)Vertebral BMF content by MRS Vertebral BMF composition by MRS Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 15), osteopenic (n = 15), osteoporotic (n = 20), and controls (n = 12)BMF content↗ and fat unsaturation index ↘ 1/osteoporotic vs normal 2/osteopenic vs normal 3/osteoporotic vs controlsAge-matched
Tang et al, 2010 (55)78 postmenopausal women (55–81 years of age)Vertebral BMF content by MRS Vertebral BMF perfusion Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 24), osteopenic (n = 25), and osteoporotic (n = 29)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Li et al, 2011 (21)51 postmenopausal women (54–73 years of age)Vertebral BMF content by MRS Anatomic site: L1–L4 MRI: 3 TeslaVertebral BMD (DXA) Normal (n = 13), osteopenic/osteoporotic (n = 38)BMF content↗ 1/osteopenic/osteoporotic versus normalAge and body mass index
Table 2.

Cross-Sectional Studies Evaluating the Relationship Between BMF and BMD in Osteoporotic Populations

StudyPopulationAdiposity MeasureBone ParametersResultsAdjustment
Griffith et al, 2005 (31)82 men (67–101 y)Vertebral BMF content by MRS Vertebral BMF perfusion (average maximum enhancement) Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 42) Osteopenic (n = 23); osteoporotic (n = 17)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Yeung et al, 2005 (32)50 postmenopausal women (66–81 years of age) and 12 controls (18–43 years)Vertebral BMF content by MRS Vertebral BMF composition by MRS Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 15), osteopenic (n = 15), osteoporotic (n = 20), and controls (n = 12)BMF content↗ and fat unsaturation index ↘ 1/osteoporotic vs normal 2/osteopenic vs normal 3/osteoporotic vs controlsAge-matched
Tang et al, 2010 (55)78 postmenopausal women (55–81 years of age)Vertebral BMF content by MRS Vertebral BMF perfusion Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 24), osteopenic (n = 25), and osteoporotic (n = 29)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Li et al, 2011 (21)51 postmenopausal women (54–73 years of age)Vertebral BMF content by MRS Anatomic site: L1–L4 MRI: 3 TeslaVertebral BMD (DXA) Normal (n = 13), osteopenic/osteoporotic (n = 38)BMF content↗ 1/osteopenic/osteoporotic versus normalAge and body mass index
StudyPopulationAdiposity MeasureBone ParametersResultsAdjustment
Griffith et al, 2005 (31)82 men (67–101 y)Vertebral BMF content by MRS Vertebral BMF perfusion (average maximum enhancement) Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 42) Osteopenic (n = 23); osteoporotic (n = 17)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Yeung et al, 2005 (32)50 postmenopausal women (66–81 years of age) and 12 controls (18–43 years)Vertebral BMF content by MRS Vertebral BMF composition by MRS Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 15), osteopenic (n = 15), osteoporotic (n = 20), and controls (n = 12)BMF content↗ and fat unsaturation index ↘ 1/osteoporotic vs normal 2/osteopenic vs normal 3/osteoporotic vs controlsAge-matched
Tang et al, 2010 (55)78 postmenopausal women (55–81 years of age)Vertebral BMF content by MRS Vertebral BMF perfusion Anatomic site: L3 MRI: 1.5 TeslaVertebral BMD (DXA) Normal (n = 24), osteopenic (n = 25), and osteoporotic (n = 29)BMF content↗ and BMF perfusion↘ 1/osteoporotic versus normal 2/osteopenic versus normalAge-matched
Li et al, 2011 (21)51 postmenopausal women (54–73 years of age)Vertebral BMF content by MRS Anatomic site: L1–L4 MRI: 3 TeslaVertebral BMD (DXA) Normal (n = 13), osteopenic/osteoporotic (n = 38)BMF content↗ 1/osteopenic/osteoporotic versus normalAge and body mass index
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