Table 3. Open in new tab Correlation...

Gene

CID

Time

Total Cholesterol

HDL Cholesterol

LDL Cholesterol

NEFA

PER1

PER2

PER3

TEF

SIRT1

CD14

CD180

NFKBIA

CCL3

ACOX3

IDH3A

Cortisol

CID2/CID1

8:00 am

0.381^a

11:15 am

3:45 pm

CID3/CID1

8:00 am

11:15 am

3:45 pm

PER1

CID2/CID1

8:00 am

−0.369^a

−0.380^a

11:15 am

0.393^a

0.374^a

0.412^a

3:45 pm

CID3/CID1

8:00 am

−0.456^a

11:15 am

0.512^b

0.538^b

0.432^a

3:45 pm

0.573^b

0.568^b

0.429^a

PER2

CID2/CID1

8:00 am

11:15 am

0.475^b

0.455^a

3:45 pm

CID3/CID1

8:00 am

0.461^a

0.601^b

11:15 am

0.512^b

0.636^b

0.479^b

3:45 pm

0.573^b

0.765^b

PER3

CID2/CID1

8:00 am

0.397^a

11:15 am

0.393^a

0.474^b

0.441^a

3:45 pm

CID3/CID1

8:00 am

0.601^b

0.450^a

11:15 am

0.538^b

0.636^b

0.724^b

3:45 pm

0.568^b

0.765^b

TEF

CID2/CID1

8:00 am

0.410^a

11:15 am

0.374^a

0.455^a

0.553^b

0.397^a

0.462^a

3:45 pm

CID3/CID1

8:00 am

0.450^a

0.401^a

11:15 am

0.432^a

0.479^b

0.724^b

0.438^a

0.590^b

3:45 pm

0.394^a

Table 3.

Open in new tab

Correlation Analysis of LC/HFD-Induced Changes of Gene Expression and Biochemical Parameters

Gene	CID	Time	Total Cholesterol	LDL Cholesterol	NEFA	PER1	PER2	PER3	TEF	SIRT1	CD14	CD180	NFKBIA	CCL3	ACOX3	IDH3A
Cortisol	CID2/CID1	8:00 am		0.381^a
		11:15 am
		3:45 pm
	CID3/CID1	8:00 am
		11:15 am
		3:45 pm
PER1	CID2/CID1	8:00 am	−0.369^a	−0.380^a
		11:15 am						0.393^a	0.374^a		0.412^a
		3:45 pm
	CID3/CID1	8:00 am										−0.456^a
		11:15 am					0.512^b	0.538^b	0.432^a
		3:45 pm					0.573^b	0.568^b							0.429^a
PER2	CID2/CID1	8:00 am
		11:15 am						0.475^b	0.455^a
		3:45 pm
	CID3/CID1	8:00 am			0.461^a			0.601^b
		11:15 am				0.512^b		0.636^b	0.479^b
		3:45 pm				0.573^b		0.765^b
PER3	CID2/CID1	8:00 am														0.397^a
		11:15 am				0.393^a	0.474^b			0.441^a
		3:45 pm
	CID3/CID1	8:00 am					0.601^b		0.450^a
		11:15 am				0.538^b	0.636^b		0.724^b
		3:45 pm				0.568^b	0.765^b
TEF	CID2/CID1	8:00 am											0.410^a
		11:15 am				0.374^a	0.455^a						0.553^b	0.397^a	0.462^a
		3:45 pm
	CID3/CID1	8:00 am						0.450^a				0.401^a
		11:15 am				0.432^a	0.479^b	0.724^b					0.438^a		0.590^b
		3:45 pm													0.394^a

Gene	CID	Time	Total Cholesterol	LDL Cholesterol	NEFA	PER1	PER2	PER3	TEF	SIRT1	CD14	CD180	NFKBIA	CCL3	ACOX3	IDH3A
Cortisol	CID2/CID1	8:00 am		0.381^a
		11:15 am
		3:45 pm
	CID3/CID1	8:00 am
		11:15 am
		3:45 pm
PER1	CID2/CID1	8:00 am	−0.369^a	−0.380^a
		11:15 am						0.393^a	0.374^a		0.412^a
		3:45 pm
	CID3/CID1	8:00 am										−0.456^a
		11:15 am					0.512^b	0.538^b	0.432^a
		3:45 pm					0.573^b	0.568^b							0.429^a
PER2	CID2/CID1	8:00 am
		11:15 am						0.475^b	0.455^a
		3:45 pm
	CID3/CID1	8:00 am			0.461^a			0.601^b
		11:15 am				0.512^b		0.636^b	0.479^b
		3:45 pm				0.573^b		0.765^b
PER3	CID2/CID1	8:00 am														0.397^a
		11:15 am				0.393^a	0.474^b			0.441^a
		3:45 pm
	CID3/CID1	8:00 am					0.601^b		0.450^a
		11:15 am				0.538^b	0.636^b		0.724^b
		3:45 pm				0.568^b	0.765^b
TEF	CID2/CID1	8:00 am											0.410^a
		11:15 am				0.374^a	0.455^a						0.553^b	0.397^a	0.462^a
		3:45 pm
	CID3/CID1	8:00 am						0.450^a				0.401^a
		11:15 am				0.432^a	0.479^b	0.724^b					0.438^a		0.590^b
		3:45 pm													0.394^a

Genes and parameters demonstrating significant expression changes in response on LC/HFD are shown (Supplemental Table 2). Parameter alterations were analyzed after 1 week (CID2/CID1) and 6 weeks (CID3/CID1) in the morning after overnight fasting (biochemical parameters) or at 3 time points (gene expression). Only significant correlation links (r values) are presented. Correlations significant after false discovery rate correction are in italics.

P < .05 without correction for multiple testing.

P < 0.01 without correction for multiple testing.

This Feature Is Available To Subscribers Only