Table 1. Open in new tab Cosinor...

Gene

CID

Cosinor Fitting

Mesor

P Value

Amplitude

P Value

Acrophase/Nadir

P Value

r²

P Value

CID1 vs CID2

CID2 vs CID3

CID1 vs CID3

CID1 vs CID2

CID2 vs CID3

CID1 vs CID3

CID1 vs CID2

CID2 vs CID3

CID1 vs CID3

Cortisol

CID1

0.42

<.001

1.50

1.60

11:59 pm

CID2

0.53

<.001

1.70

.335

.212

.139

2.80

.065

.062

.491

1:29 am

.009

.714

.002

CID3

0.48

<.001

1.80

1:16 am

BMAL1

CID1

0.28

<.001^a

1.15

0.53

1:54 pm

CID2

0.22

<.001^a

1.34

.130

.850

.074

0.28

.068

.840

.027

3:22 pm

.210

.970

.140

CID3

0.14

.002^a

1.36

0.26

3:19 pm

CLOCK

CID1

0.03

.340

CID2

0.03

.290

CID3

0.01

.780

CRY1

CID1

0.07

.046

1.06

0.44

11:38 am

CID2

0.01

.630

CID3

0.04

.150

CRY2

CID1

0.09

.016^a

1.24

0.36

11:08 am

CID2

0.06

.066

CID3

0.05

.120

DBP

CID1

0.08

.026

1.32

0.18

5:49 am

CID2

0.09

.016^a

1.35

.670

0.19

.620

6:18 am

.820

CID3

0.06

.070

NR1D1

CID1

0.12

.006^a

1.36

0.53

1:58 am

CID2

0.15

.001^a

1.32

.790

.320

.690

0.50

.830

.530

.760

2:42 am

.240

.220

1.000

CID3

0.10

.011^a

1.42

0.58

1:58 am

PER1

CID1

0.44

<.001^a

4.47

3.49

1:36 am

CID2

0.64

<.001^a

5.93

.009

.460

.030

4.99

.024

.410

.100

1:48 am

.300

.250

.810

CID3

0.64

<.001^a

5.53

4.43

1:38 am

PER2

CID1

0.25

<.001^a

2.22

0.50

6:09 am

CID2

0.29

<.001^a

2.79

.033

.630

<.001^a

0.68

.170

.490

.005

4:17 am

.380

1.000

.120

CID3

0.42

<.001^a

2.91

0.81

4:17 am

PER3

CID1

0.33

<.001^a

0.27

0.17

5:26 am

CID2

0.35

<.001^a

0.33

.093

.520

.028

0.21

.086

.360

.016

5:09 am

.850

.230

.120

CID3

0.44

<.001^a

0.36

0.24

4:03 am

TEF

CID1

0.27

<.001^a

0.87

0.39

4:20 am

CID2

0.38

<.001^a

0.97

.290

.990

.290

0.49

.140

.870

.140

4:25 am

.930

.890

.860

CID3

0.37

<.001^a

0.97

0.48

4:33 am

Table 1.

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Cosinor Analysis of Salivary Cortisol and Clock Gene Expression in Monocytes

Gene	CID	Cosinor Fitting		Mesor	P Value			Amplitude	P Value			Acrophase/Nadir	P Value
Gene	CID	r²	P Value	Mesor	CID1 vs CID2	CID2 vs CID3	CID1 vs CID3	Amplitude	CID1 vs CID2	CID2 vs CID3	CID1 vs CID3	Acrophase/Nadir	CID1 vs CID2	CID2 vs CID3	CID1 vs CID3
Cortisol	CID1	0.42	<.001	1.50				1.60				11:59 pm
	CID2	0.53	<.001	1.70	.335	.212	.139	2.80	.065	.062	.491	1:29 am	.009	.714	.002
	CID3	0.48	<.001	1.80				1.80				1:16 am
BMAL1	CID1	0.28	<.001^a	1.15				0.53				1:54 pm
	CID2	0.22	<.001^a	1.34	.130	.850	.074	0.28	.068	.840	.027	3:22 pm	.210	.970	.140
	CID3	0.14	.002^a	1.36				0.26				3:19 pm
CLOCK	CID1	0.03	.340
	CID2	0.03	.290
	CID3	0.01	.780
CRY1	CID1	0.07	.046	1.06				0.44				11:38 am
	CID2	0.01	.630
	CID3	0.04	.150
CRY2	CID1	0.09	.016^a	1.24				0.36				11:08 am
	CID2	0.06	.066
	CID3	0.05	.120
DBP	CID1	0.08	.026	1.32				0.18				5:49 am
	CID2	0.09	.016^a	1.35	.670			0.19	.620			6:18 am	.820
	CID3	0.06	.070
NR1D1	CID1	0.12	.006^a	1.36				0.53				1:58 am
	CID2	0.15	.001^a	1.32	.790	.320	.690	0.50	.830	.530	.760	2:42 am	.240	.220	1.000
	CID3	0.10	.011^a	1.42				0.58				1:58 am
PER1	CID1	0.44	<.001^a	4.47				3.49				1:36 am
	CID2	0.64	<.001^a	5.93	.009	.460	.030	4.99	.024	.410	.100	1:48 am	.300	.250	.810
	CID3	0.64	<.001^a	5.53				4.43				1:38 am
PER2	CID1	0.25	<.001^a	2.22				0.50				6:09 am
	CID2	0.29	<.001^a	2.79	.033	.630	<.001^a	0.68	.170	.490	.005	4:17 am	.380	1.000	.120
	CID3	0.42	<.001^a	2.91				0.81				4:17 am
PER3	CID1	0.33	<.001^a	0.27				0.17				5:26 am
	CID2	0.35	<.001^a	0.33	.093	.520	.028	0.21	.086	.360	.016	5:09 am	.850	.230	.120
	CID3	0.44	<.001^a	0.36				0.24				4:03 am
TEF	CID1	0.27	<.001^a	0.87				0.39				4:20 am
	CID2	0.38	<.001^a	0.97	.290	.990	.290	0.49	.140	.870	.140	4:25 am	.930	.890	.860
	CID3	0.37	<.001^a	0.97				0.48				4:33 am

Gene	CID	Cosinor Fitting		Mesor	P Value			Amplitude	P Value			Acrophase/Nadir	P Value
Gene	CID	r²	P Value	Mesor	CID1 vs CID2	CID2 vs CID3	CID1 vs CID3	Amplitude	CID1 vs CID2	CID2 vs CID3	CID1 vs CID3	Acrophase/Nadir	CID1 vs CID2	CID2 vs CID3	CID1 vs CID3
Cortisol	CID1	0.42	<.001	1.50				1.60				11:59 pm
	CID2	0.53	<.001	1.70	.335	.212	.139	2.80	.065	.062	.491	1:29 am	.009	.714	.002
	CID3	0.48	<.001	1.80				1.80				1:16 am
BMAL1	CID1	0.28	<.001^a	1.15				0.53				1:54 pm
	CID2	0.22	<.001^a	1.34	.130	.850	.074	0.28	.068	.840	.027	3:22 pm	.210	.970	.140
	CID3	0.14	.002^a	1.36				0.26				3:19 pm
CLOCK	CID1	0.03	.340
	CID2	0.03	.290
	CID3	0.01	.780
CRY1	CID1	0.07	.046	1.06				0.44				11:38 am
	CID2	0.01	.630
	CID3	0.04	.150
CRY2	CID1	0.09	.016^a	1.24				0.36				11:08 am
	CID2	0.06	.066
	CID3	0.05	.120
DBP	CID1	0.08	.026	1.32				0.18				5:49 am
	CID2	0.09	.016^a	1.35	.670			0.19	.620			6:18 am	.820
	CID3	0.06	.070
NR1D1	CID1	0.12	.006^a	1.36				0.53				1:58 am
	CID2	0.15	.001^a	1.32	.790	.320	.690	0.50	.830	.530	.760	2:42 am	.240	.220	1.000
	CID3	0.10	.011^a	1.42				0.58				1:58 am
PER1	CID1	0.44	<.001^a	4.47				3.49				1:36 am
	CID2	0.64	<.001^a	5.93	.009	.460	.030	4.99	.024	.410	.100	1:48 am	.300	.250	.810
	CID3	0.64	<.001^a	5.53				4.43				1:38 am
PER2	CID1	0.25	<.001^a	2.22				0.50				6:09 am
	CID2	0.29	<.001^a	2.79	.033	.630	<.001^a	0.68	.170	.490	.005	4:17 am	.380	1.000	.120
	CID3	0.42	<.001^a	2.91				0.81				4:17 am
PER3	CID1	0.33	<.001^a	0.27				0.17				5:26 am
	CID2	0.35	<.001^a	0.33	.093	.520	.028	0.21	.086	.360	.016	5:09 am	.850	.230	.120
	CID3	0.44	<.001^a	0.36				0.24				4:03 am
TEF	CID1	0.27	<.001^a	0.87				0.39				4:20 am
	CID2	0.38	<.001^a	0.97	.290	.990	.290	0.49	.140	.870	.140	4:25 am	.930	.890	.860
	CID3	0.37	<.001^a	0.97				0.48				4:33 am

The fitting was performed using a sinus model and an extended sinus model for clock genes and salivary cortisol, respectively. For clock genes, acrophase times are shown and for cortisol nadir times (corresponding acrophase times for cortisol are 7:04 am, 6:26 am, and 7:22 am for CID1, CID2, and CID3, respectively, P = 0.058 for CID1 vs CID2, P = 0.041 for CID2 vs CID3, P = 0.594 CID1 vs CID3; see Results for details).

P < .05 after false discovery rate correction for clock genes.

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