Table 3. Open in new tab Multivariate...

Pregnancy Weight Gain

Glucose

HbA1c

HOMA-IR

C-Peptide

P Value

miR-30a-5p

0.234

0.01

Pregestational BMI

−0.688

0.000

HOMA-IR

0.315

0.001

Adjusted R^b

0.544

miR-99b

−0.283

0.001

Pregestational BMI

−0.761

0.000

HOMA-IR

0.321

0.001

Adjusted R^b

0.586

miR-103

−0.264

0.003

Pregestational BMI

−0.711

0.000

HOMA-IR

0.284

0.002

Adjusted R^b

0.574

miR-122

−0.269

0.01

−0.242

0.02

−0.267

0.03

Pregestational BMI

0.587

0.000

0.691

0.000

Weight gain

0.408

0.006

0.361

0.01

Adjusted R^b

0.314

0.381

0.071

miR-128-a

−0.196

0.03

Pregestational BMI

−0.695

0.000

HOMA-IR

0.298

0.002

Adjusted R^b

0.541

miR-130a

0.211

0.02

Pregestational BMI

−0.682

0.000

HOMA-IR

0.306

0.002

Adjusted R^b

0.546

miR-221

−0.203

0.02

−0.358

0.003

−0.290

0.02

Pregestational BMI

−0.693

0.000

0.457

0.000

HOMA-IR

0.297

0.002

Adjusted R^b

0.544

0.249

0.084

miR-324–3p

−0.244

0.007

Pregestational BMI

−0.733

0.000

HOMA-IR

0.258

0.007

Adjusted R^b

0.563

miR-340

−0.315

0.007

−0.461

0.000

Pregestational BMI

0.362

0.002

Adjusted R^b

0.226

0.213

miR-375

−0.199

0.05

−0.252

0.02

−0.348

0.005

Pregestational BMI

0.553

0.001

0.627

0.000

Weight gain

0.416

0.007

0.344

0.01

Adjusted R^b

0.280

0.381

0.121

miR-423–5p

−0.316

0.007

−0.244

0.02

Pregestational BMI

0.383

0.001

0.634

0.000

Weight gain

0.433

0.004

Adjusted R^b

0.229

0.303

miR-652

−0.182

0.04

−0.312

0.008

−0.364

0.003

−0.287

0.01

Pregestational BMI

−0.715

0.000

0.400

0.001

0.704

0.000

HOMA-IR

0.271

0.006

0.301

0.03

Adjusted R^b

0.537

0.226

0.132

0.396

Table 3.

Open in new tab

Multivariate Regression Analyses of Obesity-Related Traits as Dependent Variables in All Pregnant Women Enrolled in this Study.

	Pregnancy Weight Gain		Glucose		HbA1c		HOMA-IR		C-Peptide		TG
	β	P Value	β	P Value	β	P Value	β	P Value	β	P Value	β	P Value
miR-30a-5p	0.234	0.01
Pregestational BMI	−0.688	0.000
HOMA-IR	0.315	0.001
Adjusted R^b	0.544
miR-99b	−0.283	0.001
Pregestational BMI	−0.761	0.000
HOMA-IR	0.321	0.001
Adjusted R^b	0.586
miR-103	−0.264	0.003
Pregestational BMI	−0.711	0.000
HOMA-IR	0.284	0.002
Adjusted R^b	0.574
miR-122							−0.269	0.01	−0.242	0.02	−0.267	0.03
Pregestational BMI							0.587	0.000	0.691	0.000
Weight gain							0.408	0.006	0.361	0.01
Adjusted R^b							0.314		0.381		0.071
miR-128-a	−0.196	0.03
Pregestational BMI	−0.695	0.000
HOMA-IR	0.298	0.002
Adjusted R^b	0.541
miR-130a	0.211	0.02
Pregestational BMI	−0.682	0.000
HOMA-IR	0.306	0.002
Adjusted R^b	0.546
miR-221	−0.203	0.02	−0.358	0.003	−0.290	0.02
Pregestational BMI	−0.693	0.000	0.457	0.000
HOMA-IR	0.297	0.002
Adjusted R^b	0.544		0.249		0.084
miR-324–3p	−0.244	0.007
Pregestational BMI	−0.733	0.000
HOMA-IR	0.258	0.007
Adjusted R^b	0.563
miR-340			−0.315	0.007	−0.461	0.000
Pregestational BMI			0.362	0.002
Adjusted R^b			0.226		0.213
miR-375							−0.199	0.05	−0.252	0.02	−0.348	0.005
Pregestational BMI							0.553	0.001	0.627	0.000
Weight gain							0.416	0.007	0.344	0.01
Adjusted R^b							0.280		0.381		0.121
miR-423–5p			−0.316	0.007			−0.244	0.02
Pregestational BMI			0.383	0.001			0.634	0.000
Weight gain							0.433	0.004
Adjusted R^b			0.229				0.303
miR-652	−0.182	0.04	−0.312	0.008	−0.364	0.003			−0.287	0.01
Pregestational BMI	−0.715	0.000	0.400	0.001					0.704	0.000
HOMA-IR	0.271	0.006							0.301	0.03
Adjusted R^b	0.537		0.226		0.132				0.396

	Pregnancy Weight Gain		Glucose		HbA1c		HOMA-IR		C-Peptide		TG
	β	P Value	β	P Value	β	P Value	β	P Value	β	P Value	β	P Value
miR-30a-5p	0.234	0.01
Pregestational BMI	−0.688	0.000
HOMA-IR	0.315	0.001
Adjusted R^b	0.544
miR-99b	−0.283	0.001
Pregestational BMI	−0.761	0.000
HOMA-IR	0.321	0.001
Adjusted R^b	0.586
miR-103	−0.264	0.003
Pregestational BMI	−0.711	0.000
HOMA-IR	0.284	0.002
Adjusted R^b	0.574
miR-122							−0.269	0.01	−0.242	0.02	−0.267	0.03
Pregestational BMI							0.587	0.000	0.691	0.000
Weight gain							0.408	0.006	0.361	0.01
Adjusted R^b							0.314		0.381		0.071
miR-128-a	−0.196	0.03
Pregestational BMI	−0.695	0.000
HOMA-IR	0.298	0.002
Adjusted R^b	0.541
miR-130a	0.211	0.02
Pregestational BMI	−0.682	0.000
HOMA-IR	0.306	0.002
Adjusted R^b	0.546
miR-221	−0.203	0.02	−0.358	0.003	−0.290	0.02
Pregestational BMI	−0.693	0.000	0.457	0.000
HOMA-IR	0.297	0.002
Adjusted R^b	0.544		0.249		0.084
miR-324–3p	−0.244	0.007
Pregestational BMI	−0.733	0.000
HOMA-IR	0.258	0.007
Adjusted R^b	0.563
miR-340			−0.315	0.007	−0.461	0.000
Pregestational BMI			0.362	0.002
Adjusted R^b			0.226		0.213
miR-375							−0.199	0.05	−0.252	0.02	−0.348	0.005
Pregestational BMI							0.553	0.001	0.627	0.000
Weight gain							0.416	0.007	0.344	0.01
Adjusted R^b							0.280		0.381		0.121
miR-423–5p			−0.316	0.007			−0.244	0.02
Pregestational BMI			0.383	0.001			0.634	0.000
Weight gain							0.433	0.004
Adjusted R^b			0.229				0.303
miR-652	−0.182	0.04	−0.312	0.008	−0.364	0.003			−0.287	0.01
Pregestational BMI	−0.715	0.000	0.400	0.001					0.704	0.000
HOMA-IR	0.271	0.006							0.301	0.03
Adjusted R^b	0.537		0.226		0.132				0.396

Data are obtained by independent multiple regression analysis in a stepwise manner. Nonpredicted variables include the following: newborns' gender, maternal age, and lipids.

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