Table 7

Elements of the TIMI380 and GUSTO381 bleeding definitions

TIMI bleeding classification380
MajorIntracranial haemorrhage or clinically overt bleeding (including imaging) ≥ 5 g/dL decrease in the haemoglobin concentration
MinorClinically overt bleeding (including imaging) with 3 to < 5 g/dL decrease in the haemoglobin concentration
MinimalClinically overt bleeding (including imaging) with a < 3 g/dL decrease in the haemoglobin concentration
GUSTO bleeding classification381
Severe or life threateningEither intracranial haemorrhage or bleeding that causes haemodynamic compromise and requires intervention
ModerateBleeding that requires blood transfusion but does not result in haemodynamic compromise
MildBleeding that does not meet criteria for either severe or moderate bleeding
TIMI bleeding classification380
MajorIntracranial haemorrhage or clinically overt bleeding (including imaging) ≥ 5 g/dL decrease in the haemoglobin concentration
MinorClinically overt bleeding (including imaging) with 3 to < 5 g/dL decrease in the haemoglobin concentration
MinimalClinically overt bleeding (including imaging) with a < 3 g/dL decrease in the haemoglobin concentration
GUSTO bleeding classification381
Severe or life threateningEither intracranial haemorrhage or bleeding that causes haemodynamic compromise and requires intervention
ModerateBleeding that requires blood transfusion but does not result in haemodynamic compromise
MildBleeding that does not meet criteria for either severe or moderate bleeding

All TIMI definitions take into account blood transfusions, such that haemoglobin values are adjusted by 1 g/dL for each unit of packed red blood transfused.

Table 7

Elements of the TIMI380 and GUSTO381 bleeding definitions

TIMI bleeding classification380
MajorIntracranial haemorrhage or clinically overt bleeding (including imaging) ≥ 5 g/dL decrease in the haemoglobin concentration
MinorClinically overt bleeding (including imaging) with 3 to < 5 g/dL decrease in the haemoglobin concentration
MinimalClinically overt bleeding (including imaging) with a < 3 g/dL decrease in the haemoglobin concentration
GUSTO bleeding classification381
Severe or life threateningEither intracranial haemorrhage or bleeding that causes haemodynamic compromise and requires intervention
ModerateBleeding that requires blood transfusion but does not result in haemodynamic compromise
MildBleeding that does not meet criteria for either severe or moderate bleeding
TIMI bleeding classification380
MajorIntracranial haemorrhage or clinically overt bleeding (including imaging) ≥ 5 g/dL decrease in the haemoglobin concentration
MinorClinically overt bleeding (including imaging) with 3 to < 5 g/dL decrease in the haemoglobin concentration
MinimalClinically overt bleeding (including imaging) with a < 3 g/dL decrease in the haemoglobin concentration
GUSTO bleeding classification381
Severe or life threateningEither intracranial haemorrhage or bleeding that causes haemodynamic compromise and requires intervention
ModerateBleeding that requires blood transfusion but does not result in haemodynamic compromise
MildBleeding that does not meet criteria for either severe or moderate bleeding

All TIMI definitions take into account blood transfusions, such that haemoglobin values are adjusted by 1 g/dL for each unit of packed red blood transfused.

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