Table 2 Open in new tab Metabolic and...

Table 2

Metabolic and Endocrine Status of Control and BATIGFIRKO Mice

	WT 3 mo	KO 3 mo	WT 12 mo	KO 12 mo
T₃, ng/mL	0.49 ± 0.04	0.56 ± 0.03	0.53 ± 0.05	0.76 ± 0.03^a,^g
IGF-I, ng/mL	141.88 ± 24.05	111.05 ± 18.69	113.51 ± 13.29	257.73 ± 36.83^b,^g
BMP7, pg/mL	2.44 ± 0.29	1.99 ± 0.17	4.22 ± 0.55^b	2.45 ± 0.30^a
Insulin, ng/mL	0.75 ± 0.05	1.44 ± 0.27	1.17 ± 0.17	1.31 ± 0.12
Glucose, mg/dL	143.06 ± 3.17	150.48 ± 3.01	137.62 ± 4.76	143 ± 3.99
TG, mg/dL	72.96 ± 6.64	104.52 ± 12.58^a	65.21 ± 10.85	133.41 ± 26.56^a
Leptin, ng/mL	2.74 ± 0.51	2.58 ± 0.45	2.05 ± 0.45	3.00 ± 0.38
Adiponectin, ng/mL	23.93 ± 0.58	22.94 ± 0.54	21.36 ± 1.12	21.74 ± 0.76
TNF-α, pg/mL	2.63 ± 0.37	1.01 ± 0.1	0.83 ± 0.09^b	0.67 ± 0.06

	WT 3 mo	KO 3 mo	WT 12 mo	KO 12 mo
T₃, ng/mL	0.49 ± 0.04	0.56 ± 0.03	0.53 ± 0.05	0.76 ± 0.03^a,^g
IGF-I, ng/mL	141.88 ± 24.05	111.05 ± 18.69	113.51 ± 13.29	257.73 ± 36.83^b,^g
BMP7, pg/mL	2.44 ± 0.29	1.99 ± 0.17	4.22 ± 0.55^b	2.45 ± 0.30^a
Insulin, ng/mL	0.75 ± 0.05	1.44 ± 0.27	1.17 ± 0.17	1.31 ± 0.12
Glucose, mg/dL	143.06 ± 3.17	150.48 ± 3.01	137.62 ± 4.76	143 ± 3.99
TG, mg/dL	72.96 ± 6.64	104.52 ± 12.58^a	65.21 ± 10.85	133.41 ± 26.56^a
Leptin, ng/mL	2.74 ± 0.51	2.58 ± 0.45	2.05 ± 0.45	3.00 ± 0.38
Adiponectin, ng/mL	23.93 ± 0.58	22.94 ± 0.54	21.36 ± 1.12	21.74 ± 0.76
TNF-α, pg/mL	2.63 ± 0.37	1.01 ± 0.1	0.83 ± 0.09^b	0.67 ± 0.06

Changes in fed plasma levels of endocrine signals such as IGFI, T3, BMP-7, insulin, leptin, adiponectin, and TNF-α and metabolites such as glucose or triglycerides are shown comparing L/L (n = 5–9) and BATIGFIRKO (n = 4–9) mice, at 3 and 12 mo, respectively. Statistical significance assessed by one-way ANOVA followed by the Bonferroni test.

P < .05;

P < .01;

P < .001 between KO and WT groups at 3 and 12 mo, respectively.

P < .05;

P < .01;

P < .001 between WT groups.

P < .05;

P < .01;

ⁱ

P < .001 between KO groups, respectively.

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