Patient Demographics, Markers of Glucose Homeostasis, and Lipid Parameters at Baseline and Postleptin Treatment
| Clinical Variables . | Baseline . | Postleptin Treatment . | P Value . |
|---|---|---|---|
| Age (y) | 18 ± 5.5 | ||
| Weight (kg) | 50.9 ± 23.3 | 47.9 ± 21.2 | .07 |
| BMI (kg/m2) | 20.8 ± 3.2 | 19.6 ± 3.4 | .05 |
| Leptin (ng/mL) | 6.4 ± 11.1 | 53.8 ± 51.2 | .09 |
| Fasting plasma glucose (mg/dL) | 144 ± 79 | 111 ± 41 | .34 |
| Fasting plasma insulin (μU/mL) | 119.4 ± 87.4 | 41.6 ± 42.5 | .03 |
| 2-h OGTT plasma glucose (mg/dL) | 180 ± 75 | 156 ± 71 | .35 |
| Hemoglobin A1C (%) | 7.9 ± 1.6 | 6.0 ± 1.8 | .04 |
| OGIS (mL/min · m2) | 360 ± 200 | 343 ± 155 | .89 |
| Total cholesterol (mg/dL) | 195 ± 64 | 146 ± 38 | .08 |
| LDL cholesterol (mg/dL) | 82 ± 46 | 68 ± 19 | .43 |
| HDL cholesterol (mg/dL) | 28 ± 8 | 29 ± 6 | .89 |
| Triglycerides (mg/dL) | 402 ± 182 | 225 ± 89 | .10 |
| Clinical Variables . | Baseline . | Postleptin Treatment . | P Value . |
|---|---|---|---|
| Age (y) | 18 ± 5.5 | ||
| Weight (kg) | 50.9 ± 23.3 | 47.9 ± 21.2 | .07 |
| BMI (kg/m2) | 20.8 ± 3.2 | 19.6 ± 3.4 | .05 |
| Leptin (ng/mL) | 6.4 ± 11.1 | 53.8 ± 51.2 | .09 |
| Fasting plasma glucose (mg/dL) | 144 ± 79 | 111 ± 41 | .34 |
| Fasting plasma insulin (μU/mL) | 119.4 ± 87.4 | 41.6 ± 42.5 | .03 |
| 2-h OGTT plasma glucose (mg/dL) | 180 ± 75 | 156 ± 71 | .35 |
| Hemoglobin A1C (%) | 7.9 ± 1.6 | 6.0 ± 1.8 | .04 |
| OGIS (mL/min · m2) | 360 ± 200 | 343 ± 155 | .89 |
| Total cholesterol (mg/dL) | 195 ± 64 | 146 ± 38 | .08 |
| LDL cholesterol (mg/dL) | 82 ± 46 | 68 ± 19 | .43 |
| HDL cholesterol (mg/dL) | 28 ± 8 | 29 ± 6 | .89 |
| Triglycerides (mg/dL) | 402 ± 182 | 225 ± 89 | .10 |
Data are presented as mean ± SD. P values are shown for comparisons between the baseline and postleptin treatment variables using a t test. P ≤ .05 are shown in bold.
Patient Demographics, Markers of Glucose Homeostasis, and Lipid Parameters at Baseline and Postleptin Treatment
| Clinical Variables . | Baseline . | Postleptin Treatment . | P Value . |
|---|---|---|---|
| Age (y) | 18 ± 5.5 | ||
| Weight (kg) | 50.9 ± 23.3 | 47.9 ± 21.2 | .07 |
| BMI (kg/m2) | 20.8 ± 3.2 | 19.6 ± 3.4 | .05 |
| Leptin (ng/mL) | 6.4 ± 11.1 | 53.8 ± 51.2 | .09 |
| Fasting plasma glucose (mg/dL) | 144 ± 79 | 111 ± 41 | .34 |
| Fasting plasma insulin (μU/mL) | 119.4 ± 87.4 | 41.6 ± 42.5 | .03 |
| 2-h OGTT plasma glucose (mg/dL) | 180 ± 75 | 156 ± 71 | .35 |
| Hemoglobin A1C (%) | 7.9 ± 1.6 | 6.0 ± 1.8 | .04 |
| OGIS (mL/min · m2) | 360 ± 200 | 343 ± 155 | .89 |
| Total cholesterol (mg/dL) | 195 ± 64 | 146 ± 38 | .08 |
| LDL cholesterol (mg/dL) | 82 ± 46 | 68 ± 19 | .43 |
| HDL cholesterol (mg/dL) | 28 ± 8 | 29 ± 6 | .89 |
| Triglycerides (mg/dL) | 402 ± 182 | 225 ± 89 | .10 |
| Clinical Variables . | Baseline . | Postleptin Treatment . | P Value . |
|---|---|---|---|
| Age (y) | 18 ± 5.5 | ||
| Weight (kg) | 50.9 ± 23.3 | 47.9 ± 21.2 | .07 |
| BMI (kg/m2) | 20.8 ± 3.2 | 19.6 ± 3.4 | .05 |
| Leptin (ng/mL) | 6.4 ± 11.1 | 53.8 ± 51.2 | .09 |
| Fasting plasma glucose (mg/dL) | 144 ± 79 | 111 ± 41 | .34 |
| Fasting plasma insulin (μU/mL) | 119.4 ± 87.4 | 41.6 ± 42.5 | .03 |
| 2-h OGTT plasma glucose (mg/dL) | 180 ± 75 | 156 ± 71 | .35 |
| Hemoglobin A1C (%) | 7.9 ± 1.6 | 6.0 ± 1.8 | .04 |
| OGIS (mL/min · m2) | 360 ± 200 | 343 ± 155 | .89 |
| Total cholesterol (mg/dL) | 195 ± 64 | 146 ± 38 | .08 |
| LDL cholesterol (mg/dL) | 82 ± 46 | 68 ± 19 | .43 |
| HDL cholesterol (mg/dL) | 28 ± 8 | 29 ± 6 | .89 |
| Triglycerides (mg/dL) | 402 ± 182 | 225 ± 89 | .10 |
Data are presented as mean ± SD. P values are shown for comparisons between the baseline and postleptin treatment variables using a t test. P ≤ .05 are shown in bold.
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