Genes Related to GABA Neurotransmission Showing Significant Changes in Hypothalamic mRNA Expression After Exposure to Low or High BPA Doses From PND1 to PND15
| Gene . | FPKM Control . | Down-Regulated log2 (Fold Change) . | P value . | Up-Regulated log2 (Fold Change) . | P value . | ||
|---|---|---|---|---|---|---|---|
| BPA 25 ng vs Control . | BPA 5 mg vs Control . | BPA 25 ng vs Control . | BPA 5 mg vs Control . | ||||
| GAD1 | 65.87 | −0.19 | .05665 | 0.35 | .00065 | ||
| GAD2 | 52.05 | −0.24 | .01670 | 0.44 | .00005 | ||
| GAT2 | 5.34 | −0.60 | .0006 | 0.39 | .00885 | ||
| GABRA2 | 16.69 | −0.18 | .10665 | 0.45 | .0015 | ||
| GABRB3 | 17.95 | −0.16 | .1294 | 0.63 | .00075 | ||
| GABRD | 20.44 | −1.09 | .00005 | 0.23 | .04135 | ||
| GABRE | 6.49 | −0.15 | .1965 | 0.71 | .00005 | ||
| GABRG2 | 43.47 | −0.04 | .73085 | 0.40 | .00075 | ||
| GABRG3 | 3.79 | −0.88 | .0003 | 0.61 | .00405 | ||
| GABRQ | 5.67 | −0.21 | .07385 | 0.70 | .00005 | ||
| Gene . | FPKM Control . | Down-Regulated log2 (Fold Change) . | P value . | Up-Regulated log2 (Fold Change) . | P value . | ||
|---|---|---|---|---|---|---|---|
| BPA 25 ng vs Control . | BPA 5 mg vs Control . | BPA 25 ng vs Control . | BPA 5 mg vs Control . | ||||
| GAD1 | 65.87 | −0.19 | .05665 | 0.35 | .00065 | ||
| GAD2 | 52.05 | −0.24 | .01670 | 0.44 | .00005 | ||
| GAT2 | 5.34 | −0.60 | .0006 | 0.39 | .00885 | ||
| GABRA2 | 16.69 | −0.18 | .10665 | 0.45 | .0015 | ||
| GABRB3 | 17.95 | −0.16 | .1294 | 0.63 | .00075 | ||
| GABRD | 20.44 | −1.09 | .00005 | 0.23 | .04135 | ||
| GABRE | 6.49 | −0.15 | .1965 | 0.71 | .00005 | ||
| GABRG2 | 43.47 | −0.04 | .73085 | 0.40 | .00075 | ||
| GABRG3 | 3.79 | −0.88 | .0003 | 0.61 | .00405 | ||
| GABRQ | 5.67 | −0.21 | .07385 | 0.70 | .00005 | ||
Abbreviations: GABR, GABA receptor; FPKM, fragments per kilobase million (digital value of expression level).
Genes Related to GABA Neurotransmission Showing Significant Changes in Hypothalamic mRNA Expression After Exposure to Low or High BPA Doses From PND1 to PND15
| Gene . | FPKM Control . | Down-Regulated log2 (Fold Change) . | P value . | Up-Regulated log2 (Fold Change) . | P value . | ||
|---|---|---|---|---|---|---|---|
| BPA 25 ng vs Control . | BPA 5 mg vs Control . | BPA 25 ng vs Control . | BPA 5 mg vs Control . | ||||
| GAD1 | 65.87 | −0.19 | .05665 | 0.35 | .00065 | ||
| GAD2 | 52.05 | −0.24 | .01670 | 0.44 | .00005 | ||
| GAT2 | 5.34 | −0.60 | .0006 | 0.39 | .00885 | ||
| GABRA2 | 16.69 | −0.18 | .10665 | 0.45 | .0015 | ||
| GABRB3 | 17.95 | −0.16 | .1294 | 0.63 | .00075 | ||
| GABRD | 20.44 | −1.09 | .00005 | 0.23 | .04135 | ||
| GABRE | 6.49 | −0.15 | .1965 | 0.71 | .00005 | ||
| GABRG2 | 43.47 | −0.04 | .73085 | 0.40 | .00075 | ||
| GABRG3 | 3.79 | −0.88 | .0003 | 0.61 | .00405 | ||
| GABRQ | 5.67 | −0.21 | .07385 | 0.70 | .00005 | ||
| Gene . | FPKM Control . | Down-Regulated log2 (Fold Change) . | P value . | Up-Regulated log2 (Fold Change) . | P value . | ||
|---|---|---|---|---|---|---|---|
| BPA 25 ng vs Control . | BPA 5 mg vs Control . | BPA 25 ng vs Control . | BPA 5 mg vs Control . | ||||
| GAD1 | 65.87 | −0.19 | .05665 | 0.35 | .00065 | ||
| GAD2 | 52.05 | −0.24 | .01670 | 0.44 | .00005 | ||
| GAT2 | 5.34 | −0.60 | .0006 | 0.39 | .00885 | ||
| GABRA2 | 16.69 | −0.18 | .10665 | 0.45 | .0015 | ||
| GABRB3 | 17.95 | −0.16 | .1294 | 0.63 | .00075 | ||
| GABRD | 20.44 | −1.09 | .00005 | 0.23 | .04135 | ||
| GABRE | 6.49 | −0.15 | .1965 | 0.71 | .00005 | ||
| GABRG2 | 43.47 | −0.04 | .73085 | 0.40 | .00075 | ||
| GABRG3 | 3.79 | −0.88 | .0003 | 0.61 | .00405 | ||
| GABRQ | 5.67 | −0.21 | .07385 | 0.70 | .00005 | ||
Abbreviations: GABR, GABA receptor; FPKM, fragments per kilobase million (digital value of expression level).
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