Suggested Cofactors to Be Included in Statistical Models for the Analysis of the Data From Developmental Experiments Designed With and Without Culling
| . | Litter Size and Composition-Related Factors Affecting Developmental Trajectories . | Known Biological Parameters Affected . | Cofactors to Be Included in Statistical Model . |
|---|---|---|---|
| No culling | Availability of nutrients during embryonic and suckling periods | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size |
| Litter sex environment | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion | Sex ratio in litter | |
| Culling | Availability of nutrients before culling | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size before culling |
| Sex environment before culling | Sexual maturation, sex steroids secretion | Sex ratio before culling | |
| Overfeeding and catch-up growth | Body weight, body composition, glucose and lipid metabolism, insulin secretion, BP, bone density, response to stress, attention, depression, lifespan | Litter size before and after culling | |
| Sex environment after culling | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion, morphology and physiology | Sex ratio after culling |
| . | Litter Size and Composition-Related Factors Affecting Developmental Trajectories . | Known Biological Parameters Affected . | Cofactors to Be Included in Statistical Model . |
|---|---|---|---|
| No culling | Availability of nutrients during embryonic and suckling periods | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size |
| Litter sex environment | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion | Sex ratio in litter | |
| Culling | Availability of nutrients before culling | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size before culling |
| Sex environment before culling | Sexual maturation, sex steroids secretion | Sex ratio before culling | |
| Overfeeding and catch-up growth | Body weight, body composition, glucose and lipid metabolism, insulin secretion, BP, bone density, response to stress, attention, depression, lifespan | Litter size before and after culling | |
| Sex environment after culling | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion, morphology and physiology | Sex ratio after culling |
Suggested Cofactors to Be Included in Statistical Models for the Analysis of the Data From Developmental Experiments Designed With and Without Culling
| . | Litter Size and Composition-Related Factors Affecting Developmental Trajectories . | Known Biological Parameters Affected . | Cofactors to Be Included in Statistical Model . |
|---|---|---|---|
| No culling | Availability of nutrients during embryonic and suckling periods | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size |
| Litter sex environment | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion | Sex ratio in litter | |
| Culling | Availability of nutrients before culling | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size before culling |
| Sex environment before culling | Sexual maturation, sex steroids secretion | Sex ratio before culling | |
| Overfeeding and catch-up growth | Body weight, body composition, glucose and lipid metabolism, insulin secretion, BP, bone density, response to stress, attention, depression, lifespan | Litter size before and after culling | |
| Sex environment after culling | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion, morphology and physiology | Sex ratio after culling |
| . | Litter Size and Composition-Related Factors Affecting Developmental Trajectories . | Known Biological Parameters Affected . | Cofactors to Be Included in Statistical Model . |
|---|---|---|---|
| No culling | Availability of nutrients during embryonic and suckling periods | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size |
| Litter sex environment | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion | Sex ratio in litter | |
| Culling | Availability of nutrients before culling | Body weight, onset of developmental landmarks, timing of sexual maturation, reflex, locomotive, emotional, and memory development, fecundity | Litter size before culling |
| Sex environment before culling | Sexual maturation, sex steroids secretion | Sex ratio before culling | |
| Overfeeding and catch-up growth | Body weight, body composition, glucose and lipid metabolism, insulin secretion, BP, bone density, response to stress, attention, depression, lifespan | Litter size before and after culling | |
| Sex environment after culling | Social behavior, brain physiology, sexual maturation and sexual performance, maternal behavior, sex steroids secretion, morphology and physiology | Sex ratio after culling |
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