Examples of Organization for Economic Co-operation and Development Test Guidelines for the Developmental and Reproductive Toxicity Assays That Refer to the Adjustment of Litter Size by Elimination of Extra Pups
| Test Type . | Culling Requirement . | Description . |
|---|---|---|
| Test number 426, developmental neurotoxicity study | Required | On or before postnatal day 4, the size of each litter should be adjusted by eliminating extra pups by random selection to yield a uniform litter size for all litters |
| Test number 443, extended 1-generation reproductive toxicity study | Recommended | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 5 males and 5 females per litter |
| Test number 415, 1-generation reproduction toxicity study | Optional | If standardization is carried out, the following procedure is suggested: on day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by selection to yield, as nearly as possible, 4 males and 4 females per litter |
| Test number 416, 2-deneration reproduction toxicity | Optional | Standardization of litter sizes is optional |
| Test number 421, reproduction/developmental toxicity screening test | Optional | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 4 or 5 pups per sex per litter depending on the normal litter size in the strain of rats used |
| Test Type . | Culling Requirement . | Description . |
|---|---|---|
| Test number 426, developmental neurotoxicity study | Required | On or before postnatal day 4, the size of each litter should be adjusted by eliminating extra pups by random selection to yield a uniform litter size for all litters |
| Test number 443, extended 1-generation reproductive toxicity study | Recommended | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 5 males and 5 females per litter |
| Test number 415, 1-generation reproduction toxicity study | Optional | If standardization is carried out, the following procedure is suggested: on day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by selection to yield, as nearly as possible, 4 males and 4 females per litter |
| Test number 416, 2-deneration reproduction toxicity | Optional | Standardization of litter sizes is optional |
| Test number 421, reproduction/developmental toxicity screening test | Optional | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 4 or 5 pups per sex per litter depending on the normal litter size in the strain of rats used |
Examples of Organization for Economic Co-operation and Development Test Guidelines for the Developmental and Reproductive Toxicity Assays That Refer to the Adjustment of Litter Size by Elimination of Extra Pups
| Test Type . | Culling Requirement . | Description . |
|---|---|---|
| Test number 426, developmental neurotoxicity study | Required | On or before postnatal day 4, the size of each litter should be adjusted by eliminating extra pups by random selection to yield a uniform litter size for all litters |
| Test number 443, extended 1-generation reproductive toxicity study | Recommended | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 5 males and 5 females per litter |
| Test number 415, 1-generation reproduction toxicity study | Optional | If standardization is carried out, the following procedure is suggested: on day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by selection to yield, as nearly as possible, 4 males and 4 females per litter |
| Test number 416, 2-deneration reproduction toxicity | Optional | Standardization of litter sizes is optional |
| Test number 421, reproduction/developmental toxicity screening test | Optional | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 4 or 5 pups per sex per litter depending on the normal litter size in the strain of rats used |
| Test Type . | Culling Requirement . | Description . |
|---|---|---|
| Test number 426, developmental neurotoxicity study | Required | On or before postnatal day 4, the size of each litter should be adjusted by eliminating extra pups by random selection to yield a uniform litter size for all litters |
| Test number 443, extended 1-generation reproductive toxicity study | Recommended | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 5 males and 5 females per litter |
| Test number 415, 1-generation reproduction toxicity study | Optional | If standardization is carried out, the following procedure is suggested: on day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by selection to yield, as nearly as possible, 4 males and 4 females per litter |
| Test number 416, 2-deneration reproduction toxicity | Optional | Standardization of litter sizes is optional |
| Test number 421, reproduction/developmental toxicity screening test | Optional | On day 4 after birth, the size of each litter may be adjusted by eliminating extra pups by random selection to yield, as nearly as possible, 4 or 5 pups per sex per litter depending on the normal litter size in the strain of rats used |
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