| . | Young Adult Mice . | Old Mice . | Premenopausal Women (n = 15) . | |||
|---|---|---|---|---|---|---|
| Gonadal Intact (n = 44) . | ovx (n = 8) . | ovx + E2 (n = 6) . | ERα−/− (n = 6) . | Gonadal Intact (n = 6) . | ||
| Estradiol, pg/mL | 2.7 ± 1.0 | <0.3a | 44.3 ± 8.0b,c | 55.9 ± 10.6b | 3.6 ± 0.7a | 54.9 ± 10.8b |
| Estrone, pg/mL | 0.4 ± 0.1 | <0.5 | <0.5 | 64.5 ± 12.0b | 0.3 ± 0.2 | 42.4 ± 4.1b |
| T, pg/mL | 51.9 ± 5.5 | 6.9 ± 2.7b | <4b | 1905 ± 247b | 23.5 ± 5.0a | 243.3 ± 26.5b |
| DHT, pg/mL | 2.8 ± 0.4 | 3.0 ± 0.7 | <1.6b,c | 39.6 ± 4.3b | 12.8 ± 2.6b | 81.7 ± 8.3b |
| Progesterone, pg/mL | 31 323 ± 6108 | 3940 ± 2135b | 674 ± 241b | 3867 ± 724b | 4104 ± 1552b | 78.8 ± 16.5b |
| Androstenedione, pg/mL | 42.9 ± 3.5 | NA | NA | NA | NA | 1088 ± 126b |
| DHEA, pg/mL | <50 | NA | NA | NA | NA | 5783 ± 1236b |
| . | Young Adult Mice . | Old Mice . | Premenopausal Women (n = 15) . | |||
|---|---|---|---|---|---|---|
| Gonadal Intact (n = 44) . | ovx (n = 8) . | ovx + E2 (n = 6) . | ERα−/− (n = 6) . | Gonadal Intact (n = 6) . | ||
| Estradiol, pg/mL | 2.7 ± 1.0 | <0.3a | 44.3 ± 8.0b,c | 55.9 ± 10.6b | 3.6 ± 0.7a | 54.9 ± 10.8b |
| Estrone, pg/mL | 0.4 ± 0.1 | <0.5 | <0.5 | 64.5 ± 12.0b | 0.3 ± 0.2 | 42.4 ± 4.1b |
| T, pg/mL | 51.9 ± 5.5 | 6.9 ± 2.7b | <4b | 1905 ± 247b | 23.5 ± 5.0a | 243.3 ± 26.5b |
| DHT, pg/mL | 2.8 ± 0.4 | 3.0 ± 0.7 | <1.6b,c | 39.6 ± 4.3b | 12.8 ± 2.6b | 81.7 ± 8.3b |
| Progesterone, pg/mL | 31 323 ± 6108 | 3940 ± 2135b | 674 ± 241b | 3867 ± 724b | 4104 ± 1552b | 78.8 ± 16.5b |
| Androstenedione, pg/mL | 42.9 ± 3.5 | NA | NA | NA | NA | 1088 ± 126b |
| DHEA, pg/mL | <50 | NA | NA | NA | NA | 5783 ± 1236b |
Abbreviations: E2, estradiol; NA, not analyzed. Serum sex steroid levels in 3- to 4-month-old (young adult) and 1-year-old (old) female mice in random cycle phase as well as in premenopausal women in the early follicular phase (mean age 31.1 ± 1.5 y, cycle d 1–10). The gonadal intact young adult female mice were also compared with ovx mice and ovx mice treated with E2 (ovx + E2). In addition, the serum levels of ERα−/− mice with disturbed negative feedback regulation of serum sex steroids are shown. Values are given as mean ± SEM.
P < .05 vs gonadal intact young adult mice;
P < .01 vs gonadal intact young adult mice;
P < .01 vs ovx young adult mice.
| . | Young Adult Mice . | Old Mice . | Premenopausal Women (n = 15) . | |||
|---|---|---|---|---|---|---|
| Gonadal Intact (n = 44) . | ovx (n = 8) . | ovx + E2 (n = 6) . | ERα−/− (n = 6) . | Gonadal Intact (n = 6) . | ||
| Estradiol, pg/mL | 2.7 ± 1.0 | <0.3a | 44.3 ± 8.0b,c | 55.9 ± 10.6b | 3.6 ± 0.7a | 54.9 ± 10.8b |
| Estrone, pg/mL | 0.4 ± 0.1 | <0.5 | <0.5 | 64.5 ± 12.0b | 0.3 ± 0.2 | 42.4 ± 4.1b |
| T, pg/mL | 51.9 ± 5.5 | 6.9 ± 2.7b | <4b | 1905 ± 247b | 23.5 ± 5.0a | 243.3 ± 26.5b |
| DHT, pg/mL | 2.8 ± 0.4 | 3.0 ± 0.7 | <1.6b,c | 39.6 ± 4.3b | 12.8 ± 2.6b | 81.7 ± 8.3b |
| Progesterone, pg/mL | 31 323 ± 6108 | 3940 ± 2135b | 674 ± 241b | 3867 ± 724b | 4104 ± 1552b | 78.8 ± 16.5b |
| Androstenedione, pg/mL | 42.9 ± 3.5 | NA | NA | NA | NA | 1088 ± 126b |
| DHEA, pg/mL | <50 | NA | NA | NA | NA | 5783 ± 1236b |
| . | Young Adult Mice . | Old Mice . | Premenopausal Women (n = 15) . | |||
|---|---|---|---|---|---|---|
| Gonadal Intact (n = 44) . | ovx (n = 8) . | ovx + E2 (n = 6) . | ERα−/− (n = 6) . | Gonadal Intact (n = 6) . | ||
| Estradiol, pg/mL | 2.7 ± 1.0 | <0.3a | 44.3 ± 8.0b,c | 55.9 ± 10.6b | 3.6 ± 0.7a | 54.9 ± 10.8b |
| Estrone, pg/mL | 0.4 ± 0.1 | <0.5 | <0.5 | 64.5 ± 12.0b | 0.3 ± 0.2 | 42.4 ± 4.1b |
| T, pg/mL | 51.9 ± 5.5 | 6.9 ± 2.7b | <4b | 1905 ± 247b | 23.5 ± 5.0a | 243.3 ± 26.5b |
| DHT, pg/mL | 2.8 ± 0.4 | 3.0 ± 0.7 | <1.6b,c | 39.6 ± 4.3b | 12.8 ± 2.6b | 81.7 ± 8.3b |
| Progesterone, pg/mL | 31 323 ± 6108 | 3940 ± 2135b | 674 ± 241b | 3867 ± 724b | 4104 ± 1552b | 78.8 ± 16.5b |
| Androstenedione, pg/mL | 42.9 ± 3.5 | NA | NA | NA | NA | 1088 ± 126b |
| DHEA, pg/mL | <50 | NA | NA | NA | NA | 5783 ± 1236b |
Abbreviations: E2, estradiol; NA, not analyzed. Serum sex steroid levels in 3- to 4-month-old (young adult) and 1-year-old (old) female mice in random cycle phase as well as in premenopausal women in the early follicular phase (mean age 31.1 ± 1.5 y, cycle d 1–10). The gonadal intact young adult female mice were also compared with ovx mice and ovx mice treated with E2 (ovx + E2). In addition, the serum levels of ERα−/− mice with disturbed negative feedback regulation of serum sex steroids are shown. Values are given as mean ± SEM.
P < .05 vs gonadal intact young adult mice;
P < .01 vs gonadal intact young adult mice;
P < .01 vs ovx young adult mice.
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