Clinical determinants of 24-hour urine calcium excretion in 99 youths with T1D
| Multiple linear regression analysis of 24-hour urine calcium excretion (fractional excretion of calcium, %)a . | ||||||
|---|---|---|---|---|---|---|
| Model . | β (95% CI) . | P . | Rb . | Additional variance explained . | AIC . | Pb . |
| Model 1 | 0.35 | 163 | − | |||
| White vs non-White racial group | 0.40 (0.12, 0.68) | .005 | − | |||
| Height velocity | −0.10 (−0.13, −0.06) | <.001 | ||||
| Fractional excretion of sodium (%) | 8.1 (3.93, 12.24) | <.001 | ||||
| Model 2 (+ markers of bone mineral metabolism) | 0.43 | 12% | 153 | .002 | ||
| White vs non-White racial group | 0.37 (0.10, 0.65) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.71 (3.70, 11.71) | <.001 | ||||
| Intact PTHa | −0.38 (−0.66, −0.09) | .010 | ||||
| Beta-c-telopeptidea | 0.35 (0.10, 0.60) | .007 | ||||
| Model 3 (+ HbA1c) | 0.46 | 5% | 151 | .03 | ||
| White vs non-White racial group | 0.45 (0.18, 0.72) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.18 (3.22, 11.13) | .001 | ||||
| Intact PTHa | −0.34 (−0.62, −0.06) | .019 | ||||
| Beta-c-telopeptidea | 0.36 (0.11, 0.61) | .005 | ||||
| HbA1c | 0.08 (0.01, 0.15) | .033 | ||||
| Alternate model 3 (+ 24-hour urine glucose) | 0.46 | 5% | 151 | .03c | ||
| White vs non-White racial group | 0.41 (0.14, 0.67) | .003 | ||||
| Height velocity | − 0.13 (−0.18, −0.08) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.06 (3.09, 11.02) | .001 | ||||
| Intact PTHb | −0.40 (−0.68, −0.12) | .006 | ||||
| Beta-c-telopeptideb | 0.33 (0.08, 0.58) | .009 | ||||
| Fractional excretion of glucose (%) | 0.07 (0.01, 0.12) | .028 | ||||
| Multiple linear regression analysis of 24-hour urine calcium excretion (fractional excretion of calcium, %)a . | ||||||
|---|---|---|---|---|---|---|
| Model . | β (95% CI) . | P . | Rb . | Additional variance explained . | AIC . | Pb . |
| Model 1 | 0.35 | 163 | − | |||
| White vs non-White racial group | 0.40 (0.12, 0.68) | .005 | − | |||
| Height velocity | −0.10 (−0.13, −0.06) | <.001 | ||||
| Fractional excretion of sodium (%) | 8.1 (3.93, 12.24) | <.001 | ||||
| Model 2 (+ markers of bone mineral metabolism) | 0.43 | 12% | 153 | .002 | ||
| White vs non-White racial group | 0.37 (0.10, 0.65) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.71 (3.70, 11.71) | <.001 | ||||
| Intact PTHa | −0.38 (−0.66, −0.09) | .010 | ||||
| Beta-c-telopeptidea | 0.35 (0.10, 0.60) | .007 | ||||
| Model 3 (+ HbA1c) | 0.46 | 5% | 151 | .03 | ||
| White vs non-White racial group | 0.45 (0.18, 0.72) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.18 (3.22, 11.13) | .001 | ||||
| Intact PTHa | −0.34 (−0.62, −0.06) | .019 | ||||
| Beta-c-telopeptidea | 0.36 (0.11, 0.61) | .005 | ||||
| HbA1c | 0.08 (0.01, 0.15) | .033 | ||||
| Alternate model 3 (+ 24-hour urine glucose) | 0.46 | 5% | 151 | .03c | ||
| White vs non-White racial group | 0.41 (0.14, 0.67) | .003 | ||||
| Height velocity | − 0.13 (−0.18, −0.08) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.06 (3.09, 11.02) | .001 | ||||
| Intact PTHb | −0.40 (−0.68, −0.12) | .006 | ||||
| Beta-c-telopeptideb | 0.33 (0.08, 0.58) | .009 | ||||
| Fractional excretion of glucose (%) | 0.07 (0.01, 0.12) | .028 | ||||
Fractional excretion of calcium calculated as [(urine calcium*serum creatinine) / (urine creatinine*serum calcium)*100].
Abbreviations: AIC, Akaike information criterion; CI, confidence interval; HbA1c, hemoglobin A1c; T1D, type 1 diabetes.
aLog-transformed.
bFor additional variables from nested regression.
cCompared to model 2.
Clinical determinants of 24-hour urine calcium excretion in 99 youths with T1D
| Multiple linear regression analysis of 24-hour urine calcium excretion (fractional excretion of calcium, %)a . | ||||||
|---|---|---|---|---|---|---|
| Model . | β (95% CI) . | P . | Rb . | Additional variance explained . | AIC . | Pb . |
| Model 1 | 0.35 | 163 | − | |||
| White vs non-White racial group | 0.40 (0.12, 0.68) | .005 | − | |||
| Height velocity | −0.10 (−0.13, −0.06) | <.001 | ||||
| Fractional excretion of sodium (%) | 8.1 (3.93, 12.24) | <.001 | ||||
| Model 2 (+ markers of bone mineral metabolism) | 0.43 | 12% | 153 | .002 | ||
| White vs non-White racial group | 0.37 (0.10, 0.65) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.71 (3.70, 11.71) | <.001 | ||||
| Intact PTHa | −0.38 (−0.66, −0.09) | .010 | ||||
| Beta-c-telopeptidea | 0.35 (0.10, 0.60) | .007 | ||||
| Model 3 (+ HbA1c) | 0.46 | 5% | 151 | .03 | ||
| White vs non-White racial group | 0.45 (0.18, 0.72) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.18 (3.22, 11.13) | .001 | ||||
| Intact PTHa | −0.34 (−0.62, −0.06) | .019 | ||||
| Beta-c-telopeptidea | 0.36 (0.11, 0.61) | .005 | ||||
| HbA1c | 0.08 (0.01, 0.15) | .033 | ||||
| Alternate model 3 (+ 24-hour urine glucose) | 0.46 | 5% | 151 | .03c | ||
| White vs non-White racial group | 0.41 (0.14, 0.67) | .003 | ||||
| Height velocity | − 0.13 (−0.18, −0.08) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.06 (3.09, 11.02) | .001 | ||||
| Intact PTHb | −0.40 (−0.68, −0.12) | .006 | ||||
| Beta-c-telopeptideb | 0.33 (0.08, 0.58) | .009 | ||||
| Fractional excretion of glucose (%) | 0.07 (0.01, 0.12) | .028 | ||||
| Multiple linear regression analysis of 24-hour urine calcium excretion (fractional excretion of calcium, %)a . | ||||||
|---|---|---|---|---|---|---|
| Model . | β (95% CI) . | P . | Rb . | Additional variance explained . | AIC . | Pb . |
| Model 1 | 0.35 | 163 | − | |||
| White vs non-White racial group | 0.40 (0.12, 0.68) | .005 | − | |||
| Height velocity | −0.10 (−0.13, −0.06) | <.001 | ||||
| Fractional excretion of sodium (%) | 8.1 (3.93, 12.24) | <.001 | ||||
| Model 2 (+ markers of bone mineral metabolism) | 0.43 | 12% | 153 | .002 | ||
| White vs non-White racial group | 0.37 (0.10, 0.65) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.71 (3.70, 11.71) | <.001 | ||||
| Intact PTHa | −0.38 (−0.66, −0.09) | .010 | ||||
| Beta-c-telopeptidea | 0.35 (0.10, 0.60) | .007 | ||||
| Model 3 (+ HbA1c) | 0.46 | 5% | 151 | .03 | ||
| White vs non-White racial group | 0.45 (0.18, 0.72) | .002 | ||||
| Height velocity | −0.14 (−0.19, −0.09) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.18 (3.22, 11.13) | .001 | ||||
| Intact PTHa | −0.34 (−0.62, −0.06) | .019 | ||||
| Beta-c-telopeptidea | 0.36 (0.11, 0.61) | .005 | ||||
| HbA1c | 0.08 (0.01, 0.15) | .033 | ||||
| Alternate model 3 (+ 24-hour urine glucose) | 0.46 | 5% | 151 | .03c | ||
| White vs non-White racial group | 0.41 (0.14, 0.67) | .003 | ||||
| Height velocity | − 0.13 (−0.18, −0.08) | <.001 | ||||
| Fractional excretion of sodium (%) | 7.06 (3.09, 11.02) | .001 | ||||
| Intact PTHb | −0.40 (−0.68, −0.12) | .006 | ||||
| Beta-c-telopeptideb | 0.33 (0.08, 0.58) | .009 | ||||
| Fractional excretion of glucose (%) | 0.07 (0.01, 0.12) | .028 | ||||
Fractional excretion of calcium calculated as [(urine calcium*serum creatinine) / (urine creatinine*serum calcium)*100].
Abbreviations: AIC, Akaike information criterion; CI, confidence interval; HbA1c, hemoglobin A1c; T1D, type 1 diabetes.
aLog-transformed.
bFor additional variables from nested regression.
cCompared to model 2.
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