| Characteristics . | Sample Size . | Median Concentration (Q1, Q3) . | Adjusted (95% CI) . | Adjusted Geometric Mean Ratio (95% CI) . | P Value . |
|---|---|---|---|---|---|
| Intercept | … | - | 6.853 (6.312, 7.393) | 946.282 (551.121, 1624.781) | <.001 |
| Birth period | … | … | … | … | |
| Prevaccine (1925–1964) | 209 | 942.2 (560.2, 1678.8) | … | … | |
| Birth cohort-specific Ab trend | … | - | −0.002 (−0.018, 0.014) | 0.998 (0.982, 1.014) | .783 |
| Pre-EPI (1965–1977) | 141 | 637.6 (370.1, 1341.0) | … | … | |
| Ab-level change postvaccine introduction (1965) | … | - | −0.179 (−0.557, 0.200) | 0.836 (0.573, 1.221) | .354 |
| Birth cohort-specific Ab trend change (1966–1977) | … | - | −0.040 (−0.086, 0.006) | 0.961 (0.917, 1.006) | .089 |
| EPI and SIAs (1978–2009) | 386 | 334.8 (160.9, 633.8) | … | … | |
| Ab-level change post EPI introduction (1978) | … | - | 0.015 (−0.415, 0.444) | 1.015 (0.660, 1.559) | .947 |
| Birth cohort–specific Ab trend change (1979–2009) | … | - | 0.018 (−0.030, 0.066) | 1.018 (0.970, 1.068) | .462 |
| Ab-level change post-SIAs introduction (1995–2009) | … | - | 0.147 (−0.201, 0.495) | 1.158 (0.818, 1.640) | .408 |
| Post-SIAs (2010–2021) | 279 | 415.5 (237.6, 812.9) | … | … | |
| Ab-level change without boosting from SIAs (2010) | … | - | −0.236 (−0.821, 0.349) | 0.790 (0.440, 1.417) | .428 |
| Birth cohort-specific Ab trend change (2011–2021) | … | - | 0.200 (0.150, 0.250) | 1.221 (1.162, 1.284) | <0.001 |
| Sex | … | … | … | … | |
| Male | 401 | 514.1 (247.5, 974.8) | Reference | Reference | - |
| Female | 614 | 465.3 (254.1, 968.0) | 0.048 (−0.071, 0.167) | 1.049 (0.931, 1.181) | .432 |
| Any underlying disease | … | … | … | … | |
| Yes | 233 | 748.0 (369.4, 1463.1) | −0.054 (−0.221, 0.113) | 0.947 (0.802, 1.119) | .525 |
| No | 762 | 440.7 (222.2, 869.6) | Reference | Reference | - |
| Unknown | 20 | 232.2 (132.1, 328.6) | −0.427 (−0.840, −0.013) | 0.653 (0.432, 0.987) | .043 |
| Socioeconomic status | … | … | … | … | |
| Low | 329 | 414.3 (240.2, 757.2) | Reference | Reference | - |
| Middle | 406 | 581.7 (311.1, 1262.1) | 0.090 (−0.188, 0.368) | 1.094 (0.828, 1.445) | .527 |
| High | 250 | 422.0 (183.4, 896.1) | 0.112 (−0.180, 0.403) | 1.118 (0.835, 1.497) | .452 |
| Missing | 30 | 508.5 (319.5, 1477.1) | 0.249 (−0.176, 0.675) | 1.283 (0.838, 1.964) | .250 |
| Characteristics . | Sample Size . | Median Concentration (Q1, Q3) . | Adjusted (95% CI) . | Adjusted Geometric Mean Ratio (95% CI) . | P Value . |
|---|---|---|---|---|---|
| Intercept | … | - | 6.853 (6.312, 7.393) | 946.282 (551.121, 1624.781) | <.001 |
| Birth period | … | … | … | … | |
| Prevaccine (1925–1964) | 209 | 942.2 (560.2, 1678.8) | … | … | |
| Birth cohort-specific Ab trend | … | - | −0.002 (−0.018, 0.014) | 0.998 (0.982, 1.014) | .783 |
| Pre-EPI (1965–1977) | 141 | 637.6 (370.1, 1341.0) | … | … | |
| Ab-level change postvaccine introduction (1965) | … | - | −0.179 (−0.557, 0.200) | 0.836 (0.573, 1.221) | .354 |
| Birth cohort-specific Ab trend change (1966–1977) | … | - | −0.040 (−0.086, 0.006) | 0.961 (0.917, 1.006) | .089 |
| EPI and SIAs (1978–2009) | 386 | 334.8 (160.9, 633.8) | … | … | |
| Ab-level change post EPI introduction (1978) | … | - | 0.015 (−0.415, 0.444) | 1.015 (0.660, 1.559) | .947 |
| Birth cohort–specific Ab trend change (1979–2009) | … | - | 0.018 (−0.030, 0.066) | 1.018 (0.970, 1.068) | .462 |
| Ab-level change post-SIAs introduction (1995–2009) | … | - | 0.147 (−0.201, 0.495) | 1.158 (0.818, 1.640) | .408 |
| Post-SIAs (2010–2021) | 279 | 415.5 (237.6, 812.9) | … | … | |
| Ab-level change without boosting from SIAs (2010) | … | - | −0.236 (−0.821, 0.349) | 0.790 (0.440, 1.417) | .428 |
| Birth cohort-specific Ab trend change (2011–2021) | … | - | 0.200 (0.150, 0.250) | 1.221 (1.162, 1.284) | <0.001 |
| Sex | … | … | … | … | |
| Male | 401 | 514.1 (247.5, 974.8) | Reference | Reference | - |
| Female | 614 | 465.3 (254.1, 968.0) | 0.048 (−0.071, 0.167) | 1.049 (0.931, 1.181) | .432 |
| Any underlying disease | … | … | … | … | |
| Yes | 233 | 748.0 (369.4, 1463.1) | −0.054 (−0.221, 0.113) | 0.947 (0.802, 1.119) | .525 |
| No | 762 | 440.7 (222.2, 869.6) | Reference | Reference | - |
| Unknown | 20 | 232.2 (132.1, 328.6) | −0.427 (−0.840, −0.013) | 0.653 (0.432, 0.987) | .043 |
| Socioeconomic status | … | … | … | … | |
| Low | 329 | 414.3 (240.2, 757.2) | Reference | Reference | - |
| Middle | 406 | 581.7 (311.1, 1262.1) | 0.090 (−0.188, 0.368) | 1.094 (0.828, 1.445) | .527 |
| High | 250 | 422.0 (183.4, 896.1) | 0.112 (−0.180, 0.403) | 1.118 (0.835, 1.497) | .452 |
| Missing | 30 | 508.5 (319.5, 1477.1) | 0.249 (−0.176, 0.675) | 1.283 (0.838, 1.964) | .250 |
Abbreviations: Ab, antibody; CI, confidence interval; EPI, National Expanded Program on Immunization; Q, quartile; SIA, supplementary immunization activity.
| Characteristics . | Sample Size . | Median Concentration (Q1, Q3) . | Adjusted (95% CI) . | Adjusted Geometric Mean Ratio (95% CI) . | P Value . |
|---|---|---|---|---|---|
| Intercept | … | - | 6.853 (6.312, 7.393) | 946.282 (551.121, 1624.781) | <.001 |
| Birth period | … | … | … | … | |
| Prevaccine (1925–1964) | 209 | 942.2 (560.2, 1678.8) | … | … | |
| Birth cohort-specific Ab trend | … | - | −0.002 (−0.018, 0.014) | 0.998 (0.982, 1.014) | .783 |
| Pre-EPI (1965–1977) | 141 | 637.6 (370.1, 1341.0) | … | … | |
| Ab-level change postvaccine introduction (1965) | … | - | −0.179 (−0.557, 0.200) | 0.836 (0.573, 1.221) | .354 |
| Birth cohort-specific Ab trend change (1966–1977) | … | - | −0.040 (−0.086, 0.006) | 0.961 (0.917, 1.006) | .089 |
| EPI and SIAs (1978–2009) | 386 | 334.8 (160.9, 633.8) | … | … | |
| Ab-level change post EPI introduction (1978) | … | - | 0.015 (−0.415, 0.444) | 1.015 (0.660, 1.559) | .947 |
| Birth cohort–specific Ab trend change (1979–2009) | … | - | 0.018 (−0.030, 0.066) | 1.018 (0.970, 1.068) | .462 |
| Ab-level change post-SIAs introduction (1995–2009) | … | - | 0.147 (−0.201, 0.495) | 1.158 (0.818, 1.640) | .408 |
| Post-SIAs (2010–2021) | 279 | 415.5 (237.6, 812.9) | … | … | |
| Ab-level change without boosting from SIAs (2010) | … | - | −0.236 (−0.821, 0.349) | 0.790 (0.440, 1.417) | .428 |
| Birth cohort-specific Ab trend change (2011–2021) | … | - | 0.200 (0.150, 0.250) | 1.221 (1.162, 1.284) | <0.001 |
| Sex | … | … | … | … | |
| Male | 401 | 514.1 (247.5, 974.8) | Reference | Reference | - |
| Female | 614 | 465.3 (254.1, 968.0) | 0.048 (−0.071, 0.167) | 1.049 (0.931, 1.181) | .432 |
| Any underlying disease | … | … | … | … | |
| Yes | 233 | 748.0 (369.4, 1463.1) | −0.054 (−0.221, 0.113) | 0.947 (0.802, 1.119) | .525 |
| No | 762 | 440.7 (222.2, 869.6) | Reference | Reference | - |
| Unknown | 20 | 232.2 (132.1, 328.6) | −0.427 (−0.840, −0.013) | 0.653 (0.432, 0.987) | .043 |
| Socioeconomic status | … | … | … | … | |
| Low | 329 | 414.3 (240.2, 757.2) | Reference | Reference | - |
| Middle | 406 | 581.7 (311.1, 1262.1) | 0.090 (−0.188, 0.368) | 1.094 (0.828, 1.445) | .527 |
| High | 250 | 422.0 (183.4, 896.1) | 0.112 (−0.180, 0.403) | 1.118 (0.835, 1.497) | .452 |
| Missing | 30 | 508.5 (319.5, 1477.1) | 0.249 (−0.176, 0.675) | 1.283 (0.838, 1.964) | .250 |
| Characteristics . | Sample Size . | Median Concentration (Q1, Q3) . | Adjusted (95% CI) . | Adjusted Geometric Mean Ratio (95% CI) . | P Value . |
|---|---|---|---|---|---|
| Intercept | … | - | 6.853 (6.312, 7.393) | 946.282 (551.121, 1624.781) | <.001 |
| Birth period | … | … | … | … | |
| Prevaccine (1925–1964) | 209 | 942.2 (560.2, 1678.8) | … | … | |
| Birth cohort-specific Ab trend | … | - | −0.002 (−0.018, 0.014) | 0.998 (0.982, 1.014) | .783 |
| Pre-EPI (1965–1977) | 141 | 637.6 (370.1, 1341.0) | … | … | |
| Ab-level change postvaccine introduction (1965) | … | - | −0.179 (−0.557, 0.200) | 0.836 (0.573, 1.221) | .354 |
| Birth cohort-specific Ab trend change (1966–1977) | … | - | −0.040 (−0.086, 0.006) | 0.961 (0.917, 1.006) | .089 |
| EPI and SIAs (1978–2009) | 386 | 334.8 (160.9, 633.8) | … | … | |
| Ab-level change post EPI introduction (1978) | … | - | 0.015 (−0.415, 0.444) | 1.015 (0.660, 1.559) | .947 |
| Birth cohort–specific Ab trend change (1979–2009) | … | - | 0.018 (−0.030, 0.066) | 1.018 (0.970, 1.068) | .462 |
| Ab-level change post-SIAs introduction (1995–2009) | … | - | 0.147 (−0.201, 0.495) | 1.158 (0.818, 1.640) | .408 |
| Post-SIAs (2010–2021) | 279 | 415.5 (237.6, 812.9) | … | … | |
| Ab-level change without boosting from SIAs (2010) | … | - | −0.236 (−0.821, 0.349) | 0.790 (0.440, 1.417) | .428 |
| Birth cohort-specific Ab trend change (2011–2021) | … | - | 0.200 (0.150, 0.250) | 1.221 (1.162, 1.284) | <0.001 |
| Sex | … | … | … | … | |
| Male | 401 | 514.1 (247.5, 974.8) | Reference | Reference | - |
| Female | 614 | 465.3 (254.1, 968.0) | 0.048 (−0.071, 0.167) | 1.049 (0.931, 1.181) | .432 |
| Any underlying disease | … | … | … | … | |
| Yes | 233 | 748.0 (369.4, 1463.1) | −0.054 (−0.221, 0.113) | 0.947 (0.802, 1.119) | .525 |
| No | 762 | 440.7 (222.2, 869.6) | Reference | Reference | - |
| Unknown | 20 | 232.2 (132.1, 328.6) | −0.427 (−0.840, −0.013) | 0.653 (0.432, 0.987) | .043 |
| Socioeconomic status | … | … | … | … | |
| Low | 329 | 414.3 (240.2, 757.2) | Reference | Reference | - |
| Middle | 406 | 581.7 (311.1, 1262.1) | 0.090 (−0.188, 0.368) | 1.094 (0.828, 1.445) | .527 |
| High | 250 | 422.0 (183.4, 896.1) | 0.112 (−0.180, 0.403) | 1.118 (0.835, 1.497) | .452 |
| Missing | 30 | 508.5 (319.5, 1477.1) | 0.249 (−0.176, 0.675) | 1.283 (0.838, 1.964) | .250 |
Abbreviations: Ab, antibody; CI, confidence interval; EPI, National Expanded Program on Immunization; Q, quartile; SIA, supplementary immunization activity.
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