| DB-03 . | T‐DXd . | T‐DM1 . | ||||
|---|---|---|---|---|---|---|
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 117 | 96.6 | 0.08 (0.03‐0.21) | 54 | 96.2 | 0.17 (0.07‐0.45) |
| Q1 | 46 | 100 | 0.01 (0‐0.11) | 19 | 100 | 0.0 (0‐Inf) |
| Q2 | 38 | 97.4 | 0.07 (0.02‐0.28) | 27 | 100 | 0.07 (0.01‐0.53) |
| Q3 | 32 | 83.4 | 0.36 (0.13‐1.02) | 33 | 100 | 0.18 (0.05‐0.59) |
| Q4 | 8 | 57.1 | Ref | 57 | 70.3 | Ref |
| DB-04 | T‐DXd | TPC | ||||
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 113 | 84.5 | 0.31 (0.18‐0.53) | 28 | 69.8 | 0.62 (0.32‐1.21) |
| Q1 | 65 | 100 | 0.1 (0.05‐0.22) | 12 | 100 | 0.07 (0.01‐0.48) |
| Q2 | 59 | 87.9 | 0.34 (0.19‐0.62) | 18 | 77.8 | 0.33 (0.14‐0.75) |
| Q3 | 49 | 63.6 | 0.66 (0.37‐1.17) | 28 | 89.1 | 0.46 (0.24‐0.89) |
| Q4 | 30 | 59.6 | Ref | 46 | 46.9 | Ref |
| DB-03 . | T‐DXd . | T‐DM1 . | ||||
|---|---|---|---|---|---|---|
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 117 | 96.6 | 0.08 (0.03‐0.21) | 54 | 96.2 | 0.17 (0.07‐0.45) |
| Q1 | 46 | 100 | 0.01 (0‐0.11) | 19 | 100 | 0.0 (0‐Inf) |
| Q2 | 38 | 97.4 | 0.07 (0.02‐0.28) | 27 | 100 | 0.07 (0.01‐0.53) |
| Q3 | 32 | 83.4 | 0.36 (0.13‐1.02) | 33 | 100 | 0.18 (0.05‐0.59) |
| Q4 | 8 | 57.1 | Ref | 57 | 70.3 | Ref |
| DB-04 | T‐DXd | TPC | ||||
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 113 | 84.5 | 0.31 (0.18‐0.53) | 28 | 69.8 | 0.62 (0.32‐1.21) |
| Q1 | 65 | 100 | 0.1 (0.05‐0.22) | 12 | 100 | 0.07 (0.01‐0.48) |
| Q2 | 59 | 87.9 | 0.34 (0.19‐0.62) | 18 | 77.8 | 0.33 (0.14‐0.75) |
| Q3 | 49 | 63.6 | 0.66 (0.37‐1.17) | 28 | 89.1 | 0.46 (0.24‐0.89) |
| Q4 | 30 | 59.6 | Ref | 46 | 46.9 | Ref |
Note: Subjects are categorized to the 4 quartiles Q1, Q2, Q3, and Q4 based on the thresholds determined from the pooled data in each study. T‐DXd treatment group had greater percentages of subjects in Q1 and Q2 due to its g‐score distribution shift to smaller g‐score (better) than the control arm in each study. TPC = treatment of physician’s choice.
| DB-03 . | T‐DXd . | T‐DM1 . | ||||
|---|---|---|---|---|---|---|
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 117 | 96.6 | 0.08 (0.03‐0.21) | 54 | 96.2 | 0.17 (0.07‐0.45) |
| Q1 | 46 | 100 | 0.01 (0‐0.11) | 19 | 100 | 0.0 (0‐Inf) |
| Q2 | 38 | 97.4 | 0.07 (0.02‐0.28) | 27 | 100 | 0.07 (0.01‐0.53) |
| Q3 | 32 | 83.4 | 0.36 (0.13‐1.02) | 33 | 100 | 0.18 (0.05‐0.59) |
| Q4 | 8 | 57.1 | Ref | 57 | 70.3 | Ref |
| DB-04 | T‐DXd | TPC | ||||
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 113 | 84.5 | 0.31 (0.18‐0.53) | 28 | 69.8 | 0.62 (0.32‐1.21) |
| Q1 | 65 | 100 | 0.1 (0.05‐0.22) | 12 | 100 | 0.07 (0.01‐0.48) |
| Q2 | 59 | 87.9 | 0.34 (0.19‐0.62) | 18 | 77.8 | 0.33 (0.14‐0.75) |
| Q3 | 49 | 63.6 | 0.66 (0.37‐1.17) | 28 | 89.1 | 0.46 (0.24‐0.89) |
| Q4 | 30 | 59.6 | Ref | 46 | 46.9 | Ref |
| DB-03 . | T‐DXd . | T‐DM1 . | ||||
|---|---|---|---|---|---|---|
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 117 | 96.6 | 0.08 (0.03‐0.21) | 54 | 96.2 | 0.17 (0.07‐0.45) |
| Q1 | 46 | 100 | 0.01 (0‐0.11) | 19 | 100 | 0.0 (0‐Inf) |
| Q2 | 38 | 97.4 | 0.07 (0.02‐0.28) | 27 | 100 | 0.07 (0.01‐0.53) |
| Q3 | 32 | 83.4 | 0.36 (0.13‐1.02) | 33 | 100 | 0.18 (0.05‐0.59) |
| Q4 | 8 | 57.1 | Ref | 57 | 70.3 | Ref |
| DB-04 | T‐DXd | TPC | ||||
| N | 1‐year OS (%) | OS HR (95%CI) | N | 1‐year OS (%) | OS HR (95%CI) | |
| dx | 113 | 84.5 | 0.31 (0.18‐0.53) | 28 | 69.8 | 0.62 (0.32‐1.21) |
| Q1 | 65 | 100 | 0.1 (0.05‐0.22) | 12 | 100 | 0.07 (0.01‐0.48) |
| Q2 | 59 | 87.9 | 0.34 (0.19‐0.62) | 18 | 77.8 | 0.33 (0.14‐0.75) |
| Q3 | 49 | 63.6 | 0.66 (0.37‐1.17) | 28 | 89.1 | 0.46 (0.24‐0.89) |
| Q4 | 30 | 59.6 | Ref | 46 | 46.9 | Ref |
Note: Subjects are categorized to the 4 quartiles Q1, Q2, Q3, and Q4 based on the thresholds determined from the pooled data in each study. T‐DXd treatment group had greater percentages of subjects in Q1 and Q2 due to its g‐score distribution shift to smaller g‐score (better) than the control arm in each study. TPC = treatment of physician’s choice.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
