Table 1.
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Reference intervals as reflected by the 2.5th and 97.5th percentiles (pc) with 90% confidence intervals (CIs) established in early pregnancy among 661 pregnant women for placental and pregnancy-associated biomarkers and stratified by weeks of pregnancy.

 n2.5th pc90% CIa97.5th pc90% CIa
sFlt-1, pg/mL
 Week 6–8644236–55960866–1046
 Week 9187323276–33916651383–1852
 Week 10229401333–45320211775–2442
 Week 11118370344–46719831772–2304
 Week 12–1463470458–54318571640–1866
PlGF, pg/mL
 Week 6–8641.81.8–3.228.923.8–29.2
 Week 91874.51.8–6.535.134.2–40.2
 Week 102296.55.0–8.343.237.6–53.6
 Week 1111811.98.8–14.258.050.9–63.4
 Week 12–146311.010.3–16.073.667.0–74.2
β-hCG, IU/L
 Week 6–8642.70.4–5.5222123–234
 Week 918723.721.8–27.9184164–215
 Week 1022924.518.1–28.4180161–207
 Week 1111820.011.0–21.0156131–187
 Week 12–146314.213.0–18.917395–223
PAPP-A, IU/L
 Week 6–8640.010.01–0.010.330.30–0.35
 Week 91870.080.07–0.101.050.91–1.20
 Week 102290.190.14–0.211.741.48–2.04
 Week 111180.310.16–0.393.062.98–3.15
 Week 12–14630.640.62–0.803.233.08–3.24
 n2.5th pc90% CIa97.5th pc90% CIa
sFlt-1, pg/mL
 Week 6–8644236–55960866–1046
 Week 9187323276–33916651383–1852
 Week 10229401333–45320211775–2442
 Week 11118370344–46719831772–2304
 Week 12–1463470458–54318571640–1866
PlGF, pg/mL
 Week 6–8641.81.8–3.228.923.8–29.2
 Week 91874.51.8–6.535.134.2–40.2
 Week 102296.55.0–8.343.237.6–53.6
 Week 1111811.98.8–14.258.050.9–63.4
 Week 12–146311.010.3–16.073.667.0–74.2
β-hCG, IU/L
 Week 6–8642.70.4–5.5222123–234
 Week 918723.721.8–27.9184164–215
 Week 1022924.518.1–28.4180161–207
 Week 1111820.011.0–21.0156131–187
 Week 12–146314.213.0–18.917395–223
PAPP-A, IU/L
 Week 6–8640.010.01–0.010.330.30–0.35
 Week 91870.080.07–0.101.050.91–1.20
 Week 102290.190.14–0.211.741.48–2.04
 Week 111180.310.16–0.393.062.98–3.15
 Week 12–14630.640.62–0.803.233.08–3.24

aLower and upper confidence limit held at minimum and maximum of the sample in “Week 6–8,” “Week 11,” and “Week 12–14.”

Table 1.
Open in new tab

Reference intervals as reflected by the 2.5th and 97.5th percentiles (pc) with 90% confidence intervals (CIs) established in early pregnancy among 661 pregnant women for placental and pregnancy-associated biomarkers and stratified by weeks of pregnancy.

 n2.5th pc90% CIa97.5th pc90% CIa
sFlt-1, pg/mL
 Week 6–8644236–55960866–1046
 Week 9187323276–33916651383–1852
 Week 10229401333–45320211775–2442
 Week 11118370344–46719831772–2304
 Week 12–1463470458–54318571640–1866
PlGF, pg/mL
 Week 6–8641.81.8–3.228.923.8–29.2
 Week 91874.51.8–6.535.134.2–40.2
 Week 102296.55.0–8.343.237.6–53.6
 Week 1111811.98.8–14.258.050.9–63.4
 Week 12–146311.010.3–16.073.667.0–74.2
β-hCG, IU/L
 Week 6–8642.70.4–5.5222123–234
 Week 918723.721.8–27.9184164–215
 Week 1022924.518.1–28.4180161–207
 Week 1111820.011.0–21.0156131–187
 Week 12–146314.213.0–18.917395–223
PAPP-A, IU/L
 Week 6–8640.010.01–0.010.330.30–0.35
 Week 91870.080.07–0.101.050.91–1.20
 Week 102290.190.14–0.211.741.48–2.04
 Week 111180.310.16–0.393.062.98–3.15
 Week 12–14630.640.62–0.803.233.08–3.24
 n2.5th pc90% CIa97.5th pc90% CIa
sFlt-1, pg/mL
 Week 6–8644236–55960866–1046
 Week 9187323276–33916651383–1852
 Week 10229401333–45320211775–2442
 Week 11118370344–46719831772–2304
 Week 12–1463470458–54318571640–1866
PlGF, pg/mL
 Week 6–8641.81.8–3.228.923.8–29.2
 Week 91874.51.8–6.535.134.2–40.2
 Week 102296.55.0–8.343.237.6–53.6
 Week 1111811.98.8–14.258.050.9–63.4
 Week 12–146311.010.3–16.073.667.0–74.2
β-hCG, IU/L
 Week 6–8642.70.4–5.5222123–234
 Week 918723.721.8–27.9184164–215
 Week 1022924.518.1–28.4180161–207
 Week 1111820.011.0–21.0156131–187
 Week 12–146314.213.0–18.917395–223
PAPP-A, IU/L
 Week 6–8640.010.01–0.010.330.30–0.35
 Week 91870.080.07–0.101.050.91–1.20
 Week 102290.190.14–0.211.741.48–2.04
 Week 111180.310.16–0.393.062.98–3.15
 Week 12–14630.640.62–0.803.233.08–3.24

aLower and upper confidence limit held at minimum and maximum of the sample in “Week 6–8,” “Week 11,” and “Week 12–14.”

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