Effect of SAPAP3 knockout (SAPAP3-KO) genotype on the likelihood of mice carrying the different genotypes—WT (wild type), HET (heterozygous), and HOM (homozygous)—finding and eating Oreo cookies buried in the cage (the number and percent of mice that carrying each genotype that found cookies in the test and number of those which found cookies that ate them are given)
| a. Study 1 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Male | ||||
| Found Oreos WT | 20/23 | 88.96 | ||
| HET | 18/22 | 81.82 | ||
| HOM | 7/20 | 35.00 | 16.75 (2) | P = −.0002 |
| Ate Oreos WT | 8/20 | 40.00 | ||
| HET | 6/18 | 33.33 | ||
| HOM | 4/7 | 57.14 | 1.25 (2) | P = .54 |
| Females | ||||
| Found Oreos WT | 18/29 | 62.07 | ||
| HET | 13/21 | 61.90 | ||
| HOM | 14/24 | 58.33 | 0.10 (2) | P = .93 |
| Ate Oreos WT | 9/18 | 50.00 | ||
| HET | 10/13 | 76.92 | ||
| HOM | 9/14 | 64.29 | 2.49 (2) | P = .28 |
| a. Study 1 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Male | ||||
| Found Oreos WT | 20/23 | 88.96 | ||
| HET | 18/22 | 81.82 | ||
| HOM | 7/20 | 35.00 | 16.75 (2) | P = −.0002 |
| Ate Oreos WT | 8/20 | 40.00 | ||
| HET | 6/18 | 33.33 | ||
| HOM | 4/7 | 57.14 | 1.25 (2) | P = .54 |
| Females | ||||
| Found Oreos WT | 18/29 | 62.07 | ||
| HET | 13/21 | 61.90 | ||
| HOM | 14/24 | 58.33 | 0.10 (2) | P = .93 |
| Ate Oreos WT | 9/18 | 50.00 | ||
| HET | 10/13 | 76.92 | ||
| HOM | 9/14 | 64.29 | 2.49 (2) | P = .28 |
| b. Study 2 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Saline-treated males | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 4/8 | 50.00 | 5.33 (1) | P < .05 |
| Ate Oreos WT | 8/8 | 100.00 | ||
| HOM | 1/4 | 25.00 | P > .1 (Fisher) | |
| Females | ||||
| Found Oreos WT | 7/8 | 87.50 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/3 | 33.33 | P > .1 (Fisher) | |
| Psilocybin-treated male | ||||
| Found Oreos WT | 7/8 | 87.5 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/2 | 50.00 | P > .10 (Fisher) | |
| Females | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 3/8 | 37.50 | 8.73 (1) | P < .01 |
| Ate Oreos WT | 7/8 | 88.89 | ||
| HOM | 1/3 | 33.33 | P > .10 (Fisher) |
| b. Study 2 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Saline-treated males | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 4/8 | 50.00 | 5.33 (1) | P < .05 |
| Ate Oreos WT | 8/8 | 100.00 | ||
| HOM | 1/4 | 25.00 | P > .1 (Fisher) | |
| Females | ||||
| Found Oreos WT | 7/8 | 87.50 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/3 | 33.33 | P > .1 (Fisher) | |
| Psilocybin-treated male | ||||
| Found Oreos WT | 7/8 | 87.5 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/2 | 50.00 | P > .10 (Fisher) | |
| Females | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 3/8 | 37.50 | 8.73 (1) | P < .01 |
| Ate Oreos WT | 7/8 | 88.89 | ||
| HOM | 1/3 | 33.33 | P > .10 (Fisher) |
Effect of SAPAP3 knockout (SAPAP3-KO) genotype on the likelihood of mice carrying the different genotypes—WT (wild type), HET (heterozygous), and HOM (homozygous)—finding and eating Oreo cookies buried in the cage (the number and percent of mice that carrying each genotype that found cookies in the test and number of those which found cookies that ate them are given)
| a. Study 1 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Male | ||||
| Found Oreos WT | 20/23 | 88.96 | ||
| HET | 18/22 | 81.82 | ||
| HOM | 7/20 | 35.00 | 16.75 (2) | P = −.0002 |
| Ate Oreos WT | 8/20 | 40.00 | ||
| HET | 6/18 | 33.33 | ||
| HOM | 4/7 | 57.14 | 1.25 (2) | P = .54 |
| Females | ||||
| Found Oreos WT | 18/29 | 62.07 | ||
| HET | 13/21 | 61.90 | ||
| HOM | 14/24 | 58.33 | 0.10 (2) | P = .93 |
| Ate Oreos WT | 9/18 | 50.00 | ||
| HET | 10/13 | 76.92 | ||
| HOM | 9/14 | 64.29 | 2.49 (2) | P = .28 |
| a. Study 1 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Male | ||||
| Found Oreos WT | 20/23 | 88.96 | ||
| HET | 18/22 | 81.82 | ||
| HOM | 7/20 | 35.00 | 16.75 (2) | P = −.0002 |
| Ate Oreos WT | 8/20 | 40.00 | ||
| HET | 6/18 | 33.33 | ||
| HOM | 4/7 | 57.14 | 1.25 (2) | P = .54 |
| Females | ||||
| Found Oreos WT | 18/29 | 62.07 | ||
| HET | 13/21 | 61.90 | ||
| HOM | 14/24 | 58.33 | 0.10 (2) | P = .93 |
| Ate Oreos WT | 9/18 | 50.00 | ||
| HET | 10/13 | 76.92 | ||
| HOM | 9/14 | 64.29 | 2.49 (2) | P = .28 |
| b. Study 2 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Saline-treated males | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 4/8 | 50.00 | 5.33 (1) | P < .05 |
| Ate Oreos WT | 8/8 | 100.00 | ||
| HOM | 1/4 | 25.00 | P > .1 (Fisher) | |
| Females | ||||
| Found Oreos WT | 7/8 | 87.50 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/3 | 33.33 | P > .1 (Fisher) | |
| Psilocybin-treated male | ||||
| Found Oreos WT | 7/8 | 87.5 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/2 | 50.00 | P > .10 (Fisher) | |
| Females | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 3/8 | 37.50 | 8.73 (1) | P < .01 |
| Ate Oreos WT | 7/8 | 88.89 | ||
| HOM | 1/3 | 33.33 | P > .10 (Fisher) |
| b. Study 2 . | ||||
|---|---|---|---|---|
| No. . | Percent . | χ2 (df) . | Significance . | |
| Saline-treated males | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 4/8 | 50.00 | 5.33 (1) | P < .05 |
| Ate Oreos WT | 8/8 | 100.00 | ||
| HOM | 1/4 | 25.00 | P > .1 (Fisher) | |
| Females | ||||
| Found Oreos WT | 7/8 | 87.50 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/3 | 33.33 | P > .1 (Fisher) | |
| Psilocybin-treated male | ||||
| Found Oreos WT | 7/8 | 87.5 | ||
| HOM | 2/8 | 25.00 | 7.27 (1) | P < .01 |
| Ate Oreos WT | 6/7 | 85.71 | ||
| HOM | 1/2 | 50.00 | P > .10 (Fisher) | |
| Females | ||||
| Found Oreos WT | 8/8 | 100.00 | ||
| HOM | 3/8 | 37.50 | 8.73 (1) | P < .01 |
| Ate Oreos WT | 7/8 | 88.89 | ||
| HOM | 1/3 | 33.33 | P > .10 (Fisher) |
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