Changes in radiological parameters according to clinical response at 12 months.
| Median BWT | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Median BWT (mm) | IQR (mm) | n | Median BWT (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | |||
| Baseline | 7.2 | 6.3-7.4 | 17 | 6.1 | 4.5-7.1 | 47 | .03 | 10.0 | 9.0-11.0 | 19 | 9.0 | 7.0-10.0 | 54 | .1 |
| 12 months | 6.4 | 4.2-7.2 | 19 | 4.4 | 3-5.8 | 49 | .003 | 8.0 | 7.0-10.0 | 13 | 7.0 | 4.0-9.0 | 56 | .2 |
| P value | .26 | <.001 | .02 | <.001 | ||||||||||
| Median BWT | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Median BWT (mm) | IQR (mm) | n | Median BWT (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | |||
| Baseline | 7.2 | 6.3-7.4 | 17 | 6.1 | 4.5-7.1 | 47 | .03 | 10.0 | 9.0-11.0 | 19 | 9.0 | 7.0-10.0 | 54 | .1 |
| 12 months | 6.4 | 4.2-7.2 | 19 | 4.4 | 3-5.8 | 49 | .003 | 8.0 | 7.0-10.0 | 13 | 7.0 | 4.0-9.0 | 56 | .2 |
| P value | .26 | <.001 | .02 | <.001 | ||||||||||
| Median stricture length | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | |||
| Baseline | 7.5 | 5.0-10.0 | 17 | 3.4 | 2.4-6.0 | 45 | .006 | 10.0 | 6.0-15.0 | 19 | 5.0 | 3.0-12.0 | 54 | .006 |
| 12 months | 5.0 | 3.3-10.0 | 16 | 3.0 | 2.0-6.0 | 31 | .04 | 10.0 | 5.0-20.0 | 13 | 3.5 | 0-6.5 | 56 | .002 |
| P value | .02 | .13 | .83 | <.001 | ||||||||||
| Median stricture length | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | |||
| Baseline | 7.5 | 5.0-10.0 | 17 | 3.4 | 2.4-6.0 | 45 | .006 | 10.0 | 6.0-15.0 | 19 | 5.0 | 3.0-12.0 | 54 | .006 |
| 12 months | 5.0 | 3.3-10.0 | 16 | 3.0 | 2.0-6.0 | 31 | .04 | 10.0 | 5.0-20.0 | 13 | 3.5 | 0-6.5 | 56 | .002 |
| P value | .02 | .13 | .83 | <.001 | ||||||||||
Clinical response defined by a reduction in the Obstructive Symptom Score at 12 months. Strictures were not detected on MRI at baseline in 5 patients, and 8 patients on IUS, and BWT and stricture length were not recorded. Values were not recorded if the IUS scan quality was poor. Stricture length was not recorded at 12 months if resolved at this point. Refer to Table S3 for further details on missing scans and study quality.
Abbreviations: BWT, bowel wall thickness; IQR, interquartile range; IUS, intestinal ultrasound; MRI, magnetic resonance imaging.
Changes in radiological parameters according to clinical response at 12 months.
| Median BWT | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Median BWT (mm) | IQR (mm) | n | Median BWT (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | |||
| Baseline | 7.2 | 6.3-7.4 | 17 | 6.1 | 4.5-7.1 | 47 | .03 | 10.0 | 9.0-11.0 | 19 | 9.0 | 7.0-10.0 | 54 | .1 |
| 12 months | 6.4 | 4.2-7.2 | 19 | 4.4 | 3-5.8 | 49 | .003 | 8.0 | 7.0-10.0 | 13 | 7.0 | 4.0-9.0 | 56 | .2 |
| P value | .26 | <.001 | .02 | <.001 | ||||||||||
| Median BWT | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Median BWT (mm) | IQR (mm) | n | Median BWT (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | Median (mm) | IQR (mm) | n | |||
| Baseline | 7.2 | 6.3-7.4 | 17 | 6.1 | 4.5-7.1 | 47 | .03 | 10.0 | 9.0-11.0 | 19 | 9.0 | 7.0-10.0 | 54 | .1 |
| 12 months | 6.4 | 4.2-7.2 | 19 | 4.4 | 3-5.8 | 49 | .003 | 8.0 | 7.0-10.0 | 13 | 7.0 | 4.0-9.0 | 56 | .2 |
| P value | .26 | <.001 | .02 | <.001 | ||||||||||
| Median stricture length | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | |||
| Baseline | 7.5 | 5.0-10.0 | 17 | 3.4 | 2.4-6.0 | 45 | .006 | 10.0 | 6.0-15.0 | 19 | 5.0 | 3.0-12.0 | 54 | .006 |
| 12 months | 5.0 | 3.3-10.0 | 16 | 3.0 | 2.0-6.0 | 31 | .04 | 10.0 | 5.0-20.0 | 13 | 3.5 | 0-6.5 | 56 | .002 |
| P value | .02 | .13 | .83 | <.001 | ||||||||||
| Median stricture length | ||||||||||||||
| IUS | MRI | |||||||||||||
| Clinical non-responder | Clinical responder | P value | Clinical non-responder | Clinical responder | P value | |||||||||
| Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | Stricture length (cm) | IQR (cm) | n | |||
| Baseline | 7.5 | 5.0-10.0 | 17 | 3.4 | 2.4-6.0 | 45 | .006 | 10.0 | 6.0-15.0 | 19 | 5.0 | 3.0-12.0 | 54 | .006 |
| 12 months | 5.0 | 3.3-10.0 | 16 | 3.0 | 2.0-6.0 | 31 | .04 | 10.0 | 5.0-20.0 | 13 | 3.5 | 0-6.5 | 56 | .002 |
| P value | .02 | .13 | .83 | <.001 | ||||||||||
Clinical response defined by a reduction in the Obstructive Symptom Score at 12 months. Strictures were not detected on MRI at baseline in 5 patients, and 8 patients on IUS, and BWT and stricture length were not recorded. Values were not recorded if the IUS scan quality was poor. Stricture length was not recorded at 12 months if resolved at this point. Refer to Table S3 for further details on missing scans and study quality.
Abbreviations: BWT, bowel wall thickness; IQR, interquartile range; IUS, intestinal ultrasound; MRI, magnetic resonance imaging.
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