Causes of death in the study population and comparison between patients receiving CRT-D and patients receiving ICD only
| Causes of death | Deaths in overall population (n = 50) | Deaths in CRT-D patients (n = 15) | Deaths in ICD-only patients (n = 35) | P-value |
|---|---|---|---|---|
| Non-sudden cardiac death, n (%) | 26 (52.0) | 5 (33.3) | 21 (60.0) | 0.084 |
| Heart failure death, n (%) | 23 (46.0) | 3 (20.0) | 20 (57.1) | 0.016 |
| Coronary death, n (%) | 3 (6.0) | 2 (13.3) | 1 (2.9) | 0.153 |
| Non-cardiac death, n (%) | 19 (38.0) | 8 (53.3) | 11 (31.4) | 0.144 |
| Cancer death, n (%) | 8 (16.0) | 3 (20.0) | 5 (14.3) | 0.614 |
| Cerebrovascular death, n (%) | 3 (6.0) | 1 (6.7) | 2 (5.7) | 0.897 |
| Death from pulmonary disease, n (%) | 2 (4.0) | 1 (6.7) | 1 (2.9) | 0.529 |
| Other non-cardiac deaths, n (%) | 6 (12.0) | 3 (20.0) | 3 (8.6) | 0.254 |
| Sudden death, n (%) | 5 (10.0) | 2 (13.3) | 3 (8.6) | 0.607 |
| Causes of death | Deaths in overall population (n = 50) | Deaths in CRT-D patients (n = 15) | Deaths in ICD-only patients (n = 35) | P-value |
|---|---|---|---|---|
| Non-sudden cardiac death, n (%) | 26 (52.0) | 5 (33.3) | 21 (60.0) | 0.084 |
| Heart failure death, n (%) | 23 (46.0) | 3 (20.0) | 20 (57.1) | 0.016 |
| Coronary death, n (%) | 3 (6.0) | 2 (13.3) | 1 (2.9) | 0.153 |
| Non-cardiac death, n (%) | 19 (38.0) | 8 (53.3) | 11 (31.4) | 0.144 |
| Cancer death, n (%) | 8 (16.0) | 3 (20.0) | 5 (14.3) | 0.614 |
| Cerebrovascular death, n (%) | 3 (6.0) | 1 (6.7) | 2 (5.7) | 0.897 |
| Death from pulmonary disease, n (%) | 2 (4.0) | 1 (6.7) | 1 (2.9) | 0.529 |
| Other non-cardiac deaths, n (%) | 6 (12.0) | 3 (20.0) | 3 (8.6) | 0.254 |
| Sudden death, n (%) | 5 (10.0) | 2 (13.3) | 3 (8.6) | 0.607 |
CRT-D, cardiac resynchronization therapy plus defibrillator device; ICD, implantable cardioverter defibrillator.
Causes of death in the study population and comparison between patients receiving CRT-D and patients receiving ICD only
| Causes of death | Deaths in overall population (n = 50) | Deaths in CRT-D patients (n = 15) | Deaths in ICD-only patients (n = 35) | P-value |
|---|---|---|---|---|
| Non-sudden cardiac death, n (%) | 26 (52.0) | 5 (33.3) | 21 (60.0) | 0.084 |
| Heart failure death, n (%) | 23 (46.0) | 3 (20.0) | 20 (57.1) | 0.016 |
| Coronary death, n (%) | 3 (6.0) | 2 (13.3) | 1 (2.9) | 0.153 |
| Non-cardiac death, n (%) | 19 (38.0) | 8 (53.3) | 11 (31.4) | 0.144 |
| Cancer death, n (%) | 8 (16.0) | 3 (20.0) | 5 (14.3) | 0.614 |
| Cerebrovascular death, n (%) | 3 (6.0) | 1 (6.7) | 2 (5.7) | 0.897 |
| Death from pulmonary disease, n (%) | 2 (4.0) | 1 (6.7) | 1 (2.9) | 0.529 |
| Other non-cardiac deaths, n (%) | 6 (12.0) | 3 (20.0) | 3 (8.6) | 0.254 |
| Sudden death, n (%) | 5 (10.0) | 2 (13.3) | 3 (8.6) | 0.607 |
| Causes of death | Deaths in overall population (n = 50) | Deaths in CRT-D patients (n = 15) | Deaths in ICD-only patients (n = 35) | P-value |
|---|---|---|---|---|
| Non-sudden cardiac death, n (%) | 26 (52.0) | 5 (33.3) | 21 (60.0) | 0.084 |
| Heart failure death, n (%) | 23 (46.0) | 3 (20.0) | 20 (57.1) | 0.016 |
| Coronary death, n (%) | 3 (6.0) | 2 (13.3) | 1 (2.9) | 0.153 |
| Non-cardiac death, n (%) | 19 (38.0) | 8 (53.3) | 11 (31.4) | 0.144 |
| Cancer death, n (%) | 8 (16.0) | 3 (20.0) | 5 (14.3) | 0.614 |
| Cerebrovascular death, n (%) | 3 (6.0) | 1 (6.7) | 2 (5.7) | 0.897 |
| Death from pulmonary disease, n (%) | 2 (4.0) | 1 (6.7) | 1 (2.9) | 0.529 |
| Other non-cardiac deaths, n (%) | 6 (12.0) | 3 (20.0) | 3 (8.6) | 0.254 |
| Sudden death, n (%) | 5 (10.0) | 2 (13.3) | 3 (8.6) | 0.607 |
CRT-D, cardiac resynchronization therapy plus defibrillator device; ICD, implantable cardioverter defibrillator.
Cumulative incidence of HF death, non-cardiac death, and SD in the ICD-only and CRT-D groups. Cumulative mortality is presented separately for the ICD-only group (blue line) and the CRT-D group (red line). Causes of death other than those described were censored. CRT-D, cardiac resynchronization therapy plus defibrillator device; HF, heart failure; ICD, implantable cardioverter defibrillator; SD, sudden death.
Cumulative incidence of HF death in responders, non-responders, and ICD-only patients (A). Cumulative incidence of non-HF death in responders, non-responders, and ICD-only patients (B). (A) Comparison by means of log-rank test of cumulative 6-year incidence of HF death shows that: responders (red line) display significantly lower cumulative incidence than non-responders (green line) (P = 0.019); non-responders have a cumulative incidence similar to that of ICD-only patients (blue line) (P = 0.340); and responders have a lower cumulative incidence than ICD-only patients (P = 0.012). (B) Comparison by means of log-rank test of cumulative 6-year incidence of non-HF death shows that: responders display significantly lower cumulative incidence than non-responders (P = 0.023); non-responders have a cumulative incidence similar to that of ICD-only patients (P = 0.168); and responders have a cumulative incidence similar to that of ICD-only patients (P = 0.212). CRT-D, cardiac resynchronization therapy plus defibrillator device; HF, heart failure; ICD, implantable cardioverter defibrillator.
