Table 3.
Open in new tab

Longitudinal associations of LLDAS attainment with organ damage accrual and flare at subsequent visit in HDAS patient cohorts

Damage accrualtFlaret
HRa (95% CI), P-valueHRb (95% CI), P-value
All patients with ≥2 visits
LLDASt-10.46 (0.33,0.64), <0.0010.72 (0.63,0.81), <0.001
LLDAS-50t-10.54 (0.34,0.86), 0.0090.58 (0.48,0.70), <0.001
≥3 m sustained LLDASt-10.32 (0.20,0.52), <0.0010.53 (0.44,0.63), <0.001
≥6 m sustained LLDASt-10.32 (0.18,0.56), <0.0010.46 (0.37,0.57), <0.001
≥12 m sustained LLDASt-10.22 (0.09,0.56), 0.0010.29 (0.21,0.40), <0.001
≥24 m sustained LLDASt-10.16 (0.02,1.20), 0.0740.31 (0.19,0.51), <0.001
REMt-10.51 (0.35,0.72), <0.0010.69 (0.60,0.80), <0.001
REM-50t-10.28 (0.15,0.53), <0.0010.57 (0.46,0.70), <0.001
≥3 m sustained REMt-10.27 (0.15,0.48), <0.0010.56 (0.46,0.69), <0.001
≥6 m sustained REMt-10.25 (0.12,0.49), <0.0010.50 (0.40,0.64), <0.001
≥12 m sustained REMt-10.25 (0.10,0.63), 0.0030.35 (0.25,0.51), <0.001
≥24 m sustained REMt-10.26 (0.06,1.17), 0.0790.18 (0.09,0.36), <0.001
Damage accrualtFlaret
HRa (95% CI), P-valueHRb (95% CI), P-value
All patients with ≥2 visits
LLDASt-10.46 (0.33,0.64), <0.0010.72 (0.63,0.81), <0.001
LLDAS-50t-10.54 (0.34,0.86), 0.0090.58 (0.48,0.70), <0.001
≥3 m sustained LLDASt-10.32 (0.20,0.52), <0.0010.53 (0.44,0.63), <0.001
≥6 m sustained LLDASt-10.32 (0.18,0.56), <0.0010.46 (0.37,0.57), <0.001
≥12 m sustained LLDASt-10.22 (0.09,0.56), 0.0010.29 (0.21,0.40), <0.001
≥24 m sustained LLDASt-10.16 (0.02,1.20), 0.0740.31 (0.19,0.51), <0.001
REMt-10.51 (0.35,0.72), <0.0010.69 (0.60,0.80), <0.001
REM-50t-10.28 (0.15,0.53), <0.0010.57 (0.46,0.70), <0.001
≥3 m sustained REMt-10.27 (0.15,0.48), <0.0010.56 (0.46,0.69), <0.001
≥6 m sustained REMt-10.25 (0.12,0.49), <0.0010.50 (0.40,0.64), <0.001
≥12 m sustained REMt-10.25 (0.10,0.63), 0.0030.35 (0.25,0.51), <0.001
≥24 m sustained REMt-10.26 (0.06,1.17), 0.0790.18 (0.09,0.36), <0.001

t-l indicates proceeding visit.

HRs adjusted for

a

age at visit, GDP and baseline damage, and

b

age at visit and GDP.

Table 3.
Open in new tab

Longitudinal associations of LLDAS attainment with organ damage accrual and flare at subsequent visit in HDAS patient cohorts

Damage accrualtFlaret
HRa (95% CI), P-valueHRb (95% CI), P-value
All patients with ≥2 visits
LLDASt-10.46 (0.33,0.64), <0.0010.72 (0.63,0.81), <0.001
LLDAS-50t-10.54 (0.34,0.86), 0.0090.58 (0.48,0.70), <0.001
≥3 m sustained LLDASt-10.32 (0.20,0.52), <0.0010.53 (0.44,0.63), <0.001
≥6 m sustained LLDASt-10.32 (0.18,0.56), <0.0010.46 (0.37,0.57), <0.001
≥12 m sustained LLDASt-10.22 (0.09,0.56), 0.0010.29 (0.21,0.40), <0.001
≥24 m sustained LLDASt-10.16 (0.02,1.20), 0.0740.31 (0.19,0.51), <0.001
REMt-10.51 (0.35,0.72), <0.0010.69 (0.60,0.80), <0.001
REM-50t-10.28 (0.15,0.53), <0.0010.57 (0.46,0.70), <0.001
≥3 m sustained REMt-10.27 (0.15,0.48), <0.0010.56 (0.46,0.69), <0.001
≥6 m sustained REMt-10.25 (0.12,0.49), <0.0010.50 (0.40,0.64), <0.001
≥12 m sustained REMt-10.25 (0.10,0.63), 0.0030.35 (0.25,0.51), <0.001
≥24 m sustained REMt-10.26 (0.06,1.17), 0.0790.18 (0.09,0.36), <0.001
Damage accrualtFlaret
HRa (95% CI), P-valueHRb (95% CI), P-value
All patients with ≥2 visits
LLDASt-10.46 (0.33,0.64), <0.0010.72 (0.63,0.81), <0.001
LLDAS-50t-10.54 (0.34,0.86), 0.0090.58 (0.48,0.70), <0.001
≥3 m sustained LLDASt-10.32 (0.20,0.52), <0.0010.53 (0.44,0.63), <0.001
≥6 m sustained LLDASt-10.32 (0.18,0.56), <0.0010.46 (0.37,0.57), <0.001
≥12 m sustained LLDASt-10.22 (0.09,0.56), 0.0010.29 (0.21,0.40), <0.001
≥24 m sustained LLDASt-10.16 (0.02,1.20), 0.0740.31 (0.19,0.51), <0.001
REMt-10.51 (0.35,0.72), <0.0010.69 (0.60,0.80), <0.001
REM-50t-10.28 (0.15,0.53), <0.0010.57 (0.46,0.70), <0.001
≥3 m sustained REMt-10.27 (0.15,0.48), <0.0010.56 (0.46,0.69), <0.001
≥6 m sustained REMt-10.25 (0.12,0.49), <0.0010.50 (0.40,0.64), <0.001
≥12 m sustained REMt-10.25 (0.10,0.63), 0.0030.35 (0.25,0.51), <0.001
≥24 m sustained REMt-10.26 (0.06,1.17), 0.0790.18 (0.09,0.36), <0.001

t-l indicates proceeding visit.

HRs adjusted for

a

age at visit, GDP and baseline damage, and

b

age at visit and GDP.

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