Table 1.

PICOS framework.

ParameterCriteria
Population
  • Included: Studies of healthy participants of any age.

  • Excluded: Studies of participants with severe symptoms of depression, schizophrenia, a mental health disorder, Alzheimer’s disease, dementia, or any condition that requires institutionalization or intensive pharmacological intervention that could be expected to interfere with any of the primary outcomes.

Intervention
  • Included: Studies of interventions of tea (Camellia sinensis) and/or the combination of theanine and caffeine, and/or theanine.

  • Excluded: Studies with co-intervention(s) from which effects of tea/theanine could not be disentangled and studies using tea interventions that contained only polyphenols, flavonoids, and catechins.

ComparisonPlacebo/water, coffee, caffeine
OutcomeCognition (Harvey, 2019)29 and/or mood and/or sleep outcomes
Study design
  • Included: Randomized controlled trials.

  • Excluded: Exposure, observational, and animal studies; systematic reviews; meta-analyses; and abstracts were excluded.

ParameterCriteria
Population
  • Included: Studies of healthy participants of any age.

  • Excluded: Studies of participants with severe symptoms of depression, schizophrenia, a mental health disorder, Alzheimer’s disease, dementia, or any condition that requires institutionalization or intensive pharmacological intervention that could be expected to interfere with any of the primary outcomes.

Intervention
  • Included: Studies of interventions of tea (Camellia sinensis) and/or the combination of theanine and caffeine, and/or theanine.

  • Excluded: Studies with co-intervention(s) from which effects of tea/theanine could not be disentangled and studies using tea interventions that contained only polyphenols, flavonoids, and catechins.

ComparisonPlacebo/water, coffee, caffeine
OutcomeCognition (Harvey, 2019)29 and/or mood and/or sleep outcomes
Study design
  • Included: Randomized controlled trials.

  • Excluded: Exposure, observational, and animal studies; systematic reviews; meta-analyses; and abstracts were excluded.

Table 1.

PICOS framework.

ParameterCriteria
Population
  • Included: Studies of healthy participants of any age.

  • Excluded: Studies of participants with severe symptoms of depression, schizophrenia, a mental health disorder, Alzheimer’s disease, dementia, or any condition that requires institutionalization or intensive pharmacological intervention that could be expected to interfere with any of the primary outcomes.

Intervention
  • Included: Studies of interventions of tea (Camellia sinensis) and/or the combination of theanine and caffeine, and/or theanine.

  • Excluded: Studies with co-intervention(s) from which effects of tea/theanine could not be disentangled and studies using tea interventions that contained only polyphenols, flavonoids, and catechins.

ComparisonPlacebo/water, coffee, caffeine
OutcomeCognition (Harvey, 2019)29 and/or mood and/or sleep outcomes
Study design
  • Included: Randomized controlled trials.

  • Excluded: Exposure, observational, and animal studies; systematic reviews; meta-analyses; and abstracts were excluded.

ParameterCriteria
Population
  • Included: Studies of healthy participants of any age.

  • Excluded: Studies of participants with severe symptoms of depression, schizophrenia, a mental health disorder, Alzheimer’s disease, dementia, or any condition that requires institutionalization or intensive pharmacological intervention that could be expected to interfere with any of the primary outcomes.

Intervention
  • Included: Studies of interventions of tea (Camellia sinensis) and/or the combination of theanine and caffeine, and/or theanine.

  • Excluded: Studies with co-intervention(s) from which effects of tea/theanine could not be disentangled and studies using tea interventions that contained only polyphenols, flavonoids, and catechins.

ComparisonPlacebo/water, coffee, caffeine
OutcomeCognition (Harvey, 2019)29 and/or mood and/or sleep outcomes
Study design
  • Included: Randomized controlled trials.

  • Excluded: Exposure, observational, and animal studies; systematic reviews; meta-analyses; and abstracts were excluded.

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