Table 2.

Overview of intervention characteristics and efficacy.

Author, yearStudy sampleStudy design, assessment timepoints, and targeted outcomeEfficacy
Significant pre/Post changeExpected directionEffect size (Cohen’s d)
Very strong methodological rigor
Brody et al., 2006Youth 11 y/o and their parent (N = 332 dyads); 53.6% female youth;
Ethnicity: AA
Median income $1655 monthly
Rural counties in GA
Design: Efficacy trial
Assessment: Pre-txt/3-mos. post-txt
Outcome: Health risk-taking behaviors
Mechanism: Regulated-communicative parenting
Youth findings: Intervention youth demonstrated lower reports of risky behavior compared to control youth (P < .05) and youth-reported targeted parenting compared to control youth (P < .05).
Parent findings: Intervention families also showed increased regulated-communicative parenting (P < .01).
YN
Brody et al., 2010Youth 17 y/o and their parent (N = 347 dyads); 58.5% youth female;
Ethnicity: AA
Income: 42% of pts lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 7-mos. after post-txt, long-term follow-up (~17 mos. after pre-txt)
Outcome: Health risk-taking behaviors
Intervention youth demonstrated significantly lower levels of risky behavior [eg, substance use, sexual behavior] (independent of life stress levels) compared to the control group at long-term follow-up (P < .05)YN
Flay et al., 2004Youth in 5th grade (M age = 10.8+/−0.6) and their parents (N = 1155 dyads)
49.5% male youth; Ethnicity: AA
Income: 77% of pts received federally subsidized school lunch
Metropolitan Chicago, IL (school-based)
Design: Cluster randomized trial [Social Development Curriculum (SDC), School/Community Intervention (SCI), Health Enhancement control curriculum (HEC)]
Assessment: Pre/post-txt
Outcome: Health risk-taking behaviors
Males in SCI had significantly lower engagement in problem behaviors (violence, provoking behavior, school delinquency, substance use, sexual intercourse, condom use) than males in HEC (P-values ranged < 0.001-0.05)
Males in SDC had marginally lower engagement in problem behaviors than males in HEC (P-values ranged 0.05-0.08)
No significant effects were shown with females (P > .05)
YY; d = 0.52 (SDC); d = 0.82 (SCI)
Kogan, Brody, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% youth female
Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Psychological
Intervention families demonstrated increased protective family management skills [parent-child communication, problem-solving] compared to the control group at 2-months post-txt (P = .023)YN
Kogan, Yu, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% female youth; Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Health risk-taking behaviors
Intervention youth demonstrated decreased frequency of unprotected sex (P < .01) and increased condom efficacy (P < .05)YN
Miller et al., 2014Youth 11 y/o and their parent (N = 272 dyads); 57% female youth;
Ethnicity: AA
Income: Median income $1655 monthly
Rural counties in GA
Design: RCT
Assessment: 8 years post-txt
Outcome: Physical health
Mechanism: Parenting strategies
Intervention youth demonstrated significantly reduced inflammation composite scores compared to control group youth (P < .001).YY; d = −0.90
Murry et al., 2005Youth 11 y/o and their mother (N = 332 dyads); 54% female youth
Ethnicity: AA
Income: 46.3% of pts. lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 3-mos. post-txt
Outcome: Psychological
Mechanism: Parenting strategies
Intervention families showed greater changes in targeted parenting skills than the control group at 3-mos. post-txt (P < .01). Positive changes in youth’s self-pride and sexual self-concept at post-txt was directly and indirectly impacted by improved parenting skillsYN
Murry et al., 2007Youth 11 y/o and their parent (N = 284 dyads); ~50% female youth
Ethnicity: AA
Income: ~40% received public assistance
Rural counties in GA
Design: RCT
Assessment: Pre-txt, 3-mos. post-txt, long-term follow-up (29 mos. post-txt)
Outcomes: Psychological; Health risk-taking behaviors
Mechanism: Parenting strategies
Intervention families demonstrated increased adaptive parenting skills at 3-mos. post-txt compared to the control group (P < .01). Increased adaptive parenting skills contributed to increased youth self-pride at 29-month follow-up (P < .01), which indirectly improved peer orientation, sexual risk intention and behavior (P < .01).YY; d = 0.49
Murry et al., 2019Youth (6th grade) aged M = 11.4 y/o and their parents (N = 421 dyads); 54% female youth; Ethnicity: AA
Income: 14% of pts. received public assistance
Rural counties in TN
Design: Three-arm RCT
Assessment: Pre/post-txt, long-term follow-up (~22 mos. post-txt)
Outcome: Health risk-taking behaviors
Mechanism: Parenting
Youth findings: Tech-based youth showed a significant decrease in risky behavior engagement intention at post-txt (P = .04) and a decrease in risky behavior engagement at long-term follow-up (P = .04). Group-based youth demonstrated a significant increase in deviant peer affiliation at post-txt (P = .002) and a non-significant reduction in risky behavior at long-term follow-up (P = .58).
Parent findings: Tech-based families showed significant improvements in parenting specific to sensitive topics (P = .03). Group-based families demonstrated significant increases in supportive parenting (P = .02).
Y (for tech youth)N
Strong methodological rigor
Ringwalt et al., 1996Youth 12-16 y/o and their parent (N = 260 dyads); 100% male youth
Ethnicity: AA
Income: 50% received free or reduced lunch
Durham, NC
Design: Random assignment trial
Assessment: Pre-txt, 18-mos. post-txt, 30-mos. post-txt
Outcome: Health risk-taking behaviors
No significant pre/post change (P > .05).
Author, yearStudy sampleStudy design, assessment timepoints, and targeted outcomeEfficacy
Significant pre/Post changeExpected directionEffect size (Cohen’s d)
Very strong methodological rigor
Brody et al., 2006Youth 11 y/o and their parent (N = 332 dyads); 53.6% female youth;
Ethnicity: AA
Median income $1655 monthly
Rural counties in GA
Design: Efficacy trial
Assessment: Pre-txt/3-mos. post-txt
Outcome: Health risk-taking behaviors
Mechanism: Regulated-communicative parenting
Youth findings: Intervention youth demonstrated lower reports of risky behavior compared to control youth (P < .05) and youth-reported targeted parenting compared to control youth (P < .05).
Parent findings: Intervention families also showed increased regulated-communicative parenting (P < .01).
YN
Brody et al., 2010Youth 17 y/o and their parent (N = 347 dyads); 58.5% youth female;
Ethnicity: AA
Income: 42% of pts lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 7-mos. after post-txt, long-term follow-up (~17 mos. after pre-txt)
Outcome: Health risk-taking behaviors
Intervention youth demonstrated significantly lower levels of risky behavior [eg, substance use, sexual behavior] (independent of life stress levels) compared to the control group at long-term follow-up (P < .05)YN
Flay et al., 2004Youth in 5th grade (M age = 10.8+/−0.6) and their parents (N = 1155 dyads)
49.5% male youth; Ethnicity: AA
Income: 77% of pts received federally subsidized school lunch
Metropolitan Chicago, IL (school-based)
Design: Cluster randomized trial [Social Development Curriculum (SDC), School/Community Intervention (SCI), Health Enhancement control curriculum (HEC)]
Assessment: Pre/post-txt
Outcome: Health risk-taking behaviors
Males in SCI had significantly lower engagement in problem behaviors (violence, provoking behavior, school delinquency, substance use, sexual intercourse, condom use) than males in HEC (P-values ranged < 0.001-0.05)
Males in SDC had marginally lower engagement in problem behaviors than males in HEC (P-values ranged 0.05-0.08)
No significant effects were shown with females (P > .05)
YY; d = 0.52 (SDC); d = 0.82 (SCI)
Kogan, Brody, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% youth female
Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Psychological
Intervention families demonstrated increased protective family management skills [parent-child communication, problem-solving] compared to the control group at 2-months post-txt (P = .023)YN
Kogan, Yu, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% female youth; Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Health risk-taking behaviors
Intervention youth demonstrated decreased frequency of unprotected sex (P < .01) and increased condom efficacy (P < .05)YN
Miller et al., 2014Youth 11 y/o and their parent (N = 272 dyads); 57% female youth;
Ethnicity: AA
Income: Median income $1655 monthly
Rural counties in GA
Design: RCT
Assessment: 8 years post-txt
Outcome: Physical health
Mechanism: Parenting strategies
Intervention youth demonstrated significantly reduced inflammation composite scores compared to control group youth (P < .001).YY; d = −0.90
Murry et al., 2005Youth 11 y/o and their mother (N = 332 dyads); 54% female youth
Ethnicity: AA
Income: 46.3% of pts. lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 3-mos. post-txt
Outcome: Psychological
Mechanism: Parenting strategies
Intervention families showed greater changes in targeted parenting skills than the control group at 3-mos. post-txt (P < .01). Positive changes in youth’s self-pride and sexual self-concept at post-txt was directly and indirectly impacted by improved parenting skillsYN
Murry et al., 2007Youth 11 y/o and their parent (N = 284 dyads); ~50% female youth
Ethnicity: AA
Income: ~40% received public assistance
Rural counties in GA
Design: RCT
Assessment: Pre-txt, 3-mos. post-txt, long-term follow-up (29 mos. post-txt)
Outcomes: Psychological; Health risk-taking behaviors
Mechanism: Parenting strategies
Intervention families demonstrated increased adaptive parenting skills at 3-mos. post-txt compared to the control group (P < .01). Increased adaptive parenting skills contributed to increased youth self-pride at 29-month follow-up (P < .01), which indirectly improved peer orientation, sexual risk intention and behavior (P < .01).YY; d = 0.49
Murry et al., 2019Youth (6th grade) aged M = 11.4 y/o and their parents (N = 421 dyads); 54% female youth; Ethnicity: AA
Income: 14% of pts. received public assistance
Rural counties in TN
Design: Three-arm RCT
Assessment: Pre/post-txt, long-term follow-up (~22 mos. post-txt)
Outcome: Health risk-taking behaviors
Mechanism: Parenting
Youth findings: Tech-based youth showed a significant decrease in risky behavior engagement intention at post-txt (P = .04) and a decrease in risky behavior engagement at long-term follow-up (P = .04). Group-based youth demonstrated a significant increase in deviant peer affiliation at post-txt (P = .002) and a non-significant reduction in risky behavior at long-term follow-up (P = .58).
Parent findings: Tech-based families showed significant improvements in parenting specific to sensitive topics (P = .03). Group-based families demonstrated significant increases in supportive parenting (P = .02).
Y (for tech youth)N
Strong methodological rigor
Ringwalt et al., 1996Youth 12-16 y/o and their parent (N = 260 dyads); 100% male youth
Ethnicity: AA
Income: 50% received free or reduced lunch
Durham, NC
Design: Random assignment trial
Assessment: Pre-txt, 18-mos. post-txt, 30-mos. post-txt
Outcome: Health risk-taking behaviors
No significant pre/post change (P > .05).

Abbreviations: AA, African American; N, No; Y, Yes.

Table 2.

Overview of intervention characteristics and efficacy.

Author, yearStudy sampleStudy design, assessment timepoints, and targeted outcomeEfficacy
Significant pre/Post changeExpected directionEffect size (Cohen’s d)
Very strong methodological rigor
Brody et al., 2006Youth 11 y/o and their parent (N = 332 dyads); 53.6% female youth;
Ethnicity: AA
Median income $1655 monthly
Rural counties in GA
Design: Efficacy trial
Assessment: Pre-txt/3-mos. post-txt
Outcome: Health risk-taking behaviors
Mechanism: Regulated-communicative parenting
Youth findings: Intervention youth demonstrated lower reports of risky behavior compared to control youth (P < .05) and youth-reported targeted parenting compared to control youth (P < .05).
Parent findings: Intervention families also showed increased regulated-communicative parenting (P < .01).
YN
Brody et al., 2010Youth 17 y/o and their parent (N = 347 dyads); 58.5% youth female;
Ethnicity: AA
Income: 42% of pts lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 7-mos. after post-txt, long-term follow-up (~17 mos. after pre-txt)
Outcome: Health risk-taking behaviors
Intervention youth demonstrated significantly lower levels of risky behavior [eg, substance use, sexual behavior] (independent of life stress levels) compared to the control group at long-term follow-up (P < .05)YN
Flay et al., 2004Youth in 5th grade (M age = 10.8+/−0.6) and their parents (N = 1155 dyads)
49.5% male youth; Ethnicity: AA
Income: 77% of pts received federally subsidized school lunch
Metropolitan Chicago, IL (school-based)
Design: Cluster randomized trial [Social Development Curriculum (SDC), School/Community Intervention (SCI), Health Enhancement control curriculum (HEC)]
Assessment: Pre/post-txt
Outcome: Health risk-taking behaviors
Males in SCI had significantly lower engagement in problem behaviors (violence, provoking behavior, school delinquency, substance use, sexual intercourse, condom use) than males in HEC (P-values ranged < 0.001-0.05)
Males in SDC had marginally lower engagement in problem behaviors than males in HEC (P-values ranged 0.05-0.08)
No significant effects were shown with females (P > .05)
YY; d = 0.52 (SDC); d = 0.82 (SCI)
Kogan, Brody, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% youth female
Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Psychological
Intervention families demonstrated increased protective family management skills [parent-child communication, problem-solving] compared to the control group at 2-months post-txt (P = .023)YN
Kogan, Yu, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% female youth; Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Health risk-taking behaviors
Intervention youth demonstrated decreased frequency of unprotected sex (P < .01) and increased condom efficacy (P < .05)YN
Miller et al., 2014Youth 11 y/o and their parent (N = 272 dyads); 57% female youth;
Ethnicity: AA
Income: Median income $1655 monthly
Rural counties in GA
Design: RCT
Assessment: 8 years post-txt
Outcome: Physical health
Mechanism: Parenting strategies
Intervention youth demonstrated significantly reduced inflammation composite scores compared to control group youth (P < .001).YY; d = −0.90
Murry et al., 2005Youth 11 y/o and their mother (N = 332 dyads); 54% female youth
Ethnicity: AA
Income: 46.3% of pts. lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 3-mos. post-txt
Outcome: Psychological
Mechanism: Parenting strategies
Intervention families showed greater changes in targeted parenting skills than the control group at 3-mos. post-txt (P < .01). Positive changes in youth’s self-pride and sexual self-concept at post-txt was directly and indirectly impacted by improved parenting skillsYN
Murry et al., 2007Youth 11 y/o and their parent (N = 284 dyads); ~50% female youth
Ethnicity: AA
Income: ~40% received public assistance
Rural counties in GA
Design: RCT
Assessment: Pre-txt, 3-mos. post-txt, long-term follow-up (29 mos. post-txt)
Outcomes: Psychological; Health risk-taking behaviors
Mechanism: Parenting strategies
Intervention families demonstrated increased adaptive parenting skills at 3-mos. post-txt compared to the control group (P < .01). Increased adaptive parenting skills contributed to increased youth self-pride at 29-month follow-up (P < .01), which indirectly improved peer orientation, sexual risk intention and behavior (P < .01).YY; d = 0.49
Murry et al., 2019Youth (6th grade) aged M = 11.4 y/o and their parents (N = 421 dyads); 54% female youth; Ethnicity: AA
Income: 14% of pts. received public assistance
Rural counties in TN
Design: Three-arm RCT
Assessment: Pre/post-txt, long-term follow-up (~22 mos. post-txt)
Outcome: Health risk-taking behaviors
Mechanism: Parenting
Youth findings: Tech-based youth showed a significant decrease in risky behavior engagement intention at post-txt (P = .04) and a decrease in risky behavior engagement at long-term follow-up (P = .04). Group-based youth demonstrated a significant increase in deviant peer affiliation at post-txt (P = .002) and a non-significant reduction in risky behavior at long-term follow-up (P = .58).
Parent findings: Tech-based families showed significant improvements in parenting specific to sensitive topics (P = .03). Group-based families demonstrated significant increases in supportive parenting (P = .02).
Y (for tech youth)N
Strong methodological rigor
Ringwalt et al., 1996Youth 12-16 y/o and their parent (N = 260 dyads); 100% male youth
Ethnicity: AA
Income: 50% received free or reduced lunch
Durham, NC
Design: Random assignment trial
Assessment: Pre-txt, 18-mos. post-txt, 30-mos. post-txt
Outcome: Health risk-taking behaviors
No significant pre/post change (P > .05).
Author, yearStudy sampleStudy design, assessment timepoints, and targeted outcomeEfficacy
Significant pre/Post changeExpected directionEffect size (Cohen’s d)
Very strong methodological rigor
Brody et al., 2006Youth 11 y/o and their parent (N = 332 dyads); 53.6% female youth;
Ethnicity: AA
Median income $1655 monthly
Rural counties in GA
Design: Efficacy trial
Assessment: Pre-txt/3-mos. post-txt
Outcome: Health risk-taking behaviors
Mechanism: Regulated-communicative parenting
Youth findings: Intervention youth demonstrated lower reports of risky behavior compared to control youth (P < .05) and youth-reported targeted parenting compared to control youth (P < .05).
Parent findings: Intervention families also showed increased regulated-communicative parenting (P < .01).
YN
Brody et al., 2010Youth 17 y/o and their parent (N = 347 dyads); 58.5% youth female;
Ethnicity: AA
Income: 42% of pts lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 7-mos. after post-txt, long-term follow-up (~17 mos. after pre-txt)
Outcome: Health risk-taking behaviors
Intervention youth demonstrated significantly lower levels of risky behavior [eg, substance use, sexual behavior] (independent of life stress levels) compared to the control group at long-term follow-up (P < .05)YN
Flay et al., 2004Youth in 5th grade (M age = 10.8+/−0.6) and their parents (N = 1155 dyads)
49.5% male youth; Ethnicity: AA
Income: 77% of pts received federally subsidized school lunch
Metropolitan Chicago, IL (school-based)
Design: Cluster randomized trial [Social Development Curriculum (SDC), School/Community Intervention (SCI), Health Enhancement control curriculum (HEC)]
Assessment: Pre/post-txt
Outcome: Health risk-taking behaviors
Males in SCI had significantly lower engagement in problem behaviors (violence, provoking behavior, school delinquency, substance use, sexual intercourse, condom use) than males in HEC (P-values ranged < 0.001-0.05)
Males in SDC had marginally lower engagement in problem behaviors than males in HEC (P-values ranged 0.05-0.08)
No significant effects were shown with females (P > .05)
YY; d = 0.52 (SDC); d = 0.82 (SCI)
Kogan, Brody, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% youth female
Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Psychological
Intervention families demonstrated increased protective family management skills [parent-child communication, problem-solving] compared to the control group at 2-months post-txt (P = .023)YN
Kogan, Yu, et al., 2012Youth 15-16 y/o and their parent (N = 502 dyads); 51% female youth; Ethnicity: AA
Income: 71.3% of pts. Lived within 150% of poverty line
Rural counties in GA
Design: Randomized attention-controlled trial
Assessment: Pre-txt, 2 mos. post-txt
Outcome: Health risk-taking behaviors
Intervention youth demonstrated decreased frequency of unprotected sex (P < .01) and increased condom efficacy (P < .05)YN
Miller et al., 2014Youth 11 y/o and their parent (N = 272 dyads); 57% female youth;
Ethnicity: AA
Income: Median income $1655 monthly
Rural counties in GA
Design: RCT
Assessment: 8 years post-txt
Outcome: Physical health
Mechanism: Parenting strategies
Intervention youth demonstrated significantly reduced inflammation composite scores compared to control group youth (P < .001).YY; d = −0.90
Murry et al., 2005Youth 11 y/o and their mother (N = 332 dyads); 54% female youth
Ethnicity: AA
Income: 46.3% of pts. lived below poverty line
Rural counties in GA
Design: Randomized trial
Assessment: Pre-txt, 3-mos. post-txt
Outcome: Psychological
Mechanism: Parenting strategies
Intervention families showed greater changes in targeted parenting skills than the control group at 3-mos. post-txt (P < .01). Positive changes in youth’s self-pride and sexual self-concept at post-txt was directly and indirectly impacted by improved parenting skillsYN
Murry et al., 2007Youth 11 y/o and their parent (N = 284 dyads); ~50% female youth
Ethnicity: AA
Income: ~40% received public assistance
Rural counties in GA
Design: RCT
Assessment: Pre-txt, 3-mos. post-txt, long-term follow-up (29 mos. post-txt)
Outcomes: Psychological; Health risk-taking behaviors
Mechanism: Parenting strategies
Intervention families demonstrated increased adaptive parenting skills at 3-mos. post-txt compared to the control group (P < .01). Increased adaptive parenting skills contributed to increased youth self-pride at 29-month follow-up (P < .01), which indirectly improved peer orientation, sexual risk intention and behavior (P < .01).YY; d = 0.49
Murry et al., 2019Youth (6th grade) aged M = 11.4 y/o and their parents (N = 421 dyads); 54% female youth; Ethnicity: AA
Income: 14% of pts. received public assistance
Rural counties in TN
Design: Three-arm RCT
Assessment: Pre/post-txt, long-term follow-up (~22 mos. post-txt)
Outcome: Health risk-taking behaviors
Mechanism: Parenting
Youth findings: Tech-based youth showed a significant decrease in risky behavior engagement intention at post-txt (P = .04) and a decrease in risky behavior engagement at long-term follow-up (P = .04). Group-based youth demonstrated a significant increase in deviant peer affiliation at post-txt (P = .002) and a non-significant reduction in risky behavior at long-term follow-up (P = .58).
Parent findings: Tech-based families showed significant improvements in parenting specific to sensitive topics (P = .03). Group-based families demonstrated significant increases in supportive parenting (P = .02).
Y (for tech youth)N
Strong methodological rigor
Ringwalt et al., 1996Youth 12-16 y/o and their parent (N = 260 dyads); 100% male youth
Ethnicity: AA
Income: 50% received free or reduced lunch
Durham, NC
Design: Random assignment trial
Assessment: Pre-txt, 18-mos. post-txt, 30-mos. post-txt
Outcome: Health risk-taking behaviors
No significant pre/post change (P > .05).

Abbreviations: AA, African American; N, No; Y, Yes.

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