Family . | Fetal sex . | Gestational age . | Fetal DNA fraction (%) . | Genotype . | Number of SNPs in the haplotype block adjacent to the SEA deletion determined by dHapSeq . | SNPs used in NIPT . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Father . | Mother . | Fetus . | Father . | Mother . | Overlappeda . | Paternal informativeb . | Maternal informativec . | ||||
α-thal F1 | M | 14wk 3d | 9.3 | αα/--SEA | αα/--SEA | --SEA/--SEA | 97 | 61 | 61 | 15 | 15 |
α-thal F2 | F | 12wk 3d | 13.2 | αα/αα | αα/--SEA | αα/--SEA | 82 | 61 | 61 | 0d | 13 |
α-thal F3 | F | 18wk 2d | 7.7 | αα/--SEA | αα/--SEA | --SEA/--SEA | 87 | 61 | 61 | 11 | 16 |
α-thal F4 | M | 17wk 1d | 7.1 | αα/--SEA | αα/--SEA | αα/--SEA | 97 | 65 | 65 | 16 | 31 |
Family . | Fetal sex . | Gestational age . | Fetal DNA fraction (%) . | Genotype . | Number of SNPs in the haplotype block adjacent to the SEA deletion determined by dHapSeq . | SNPs used in NIPT . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Father . | Mother . | Fetus . | Father . | Mother . | Overlappeda . | Paternal informativeb . | Maternal informativec . | ||||
α-thal F1 | M | 14wk 3d | 9.3 | αα/--SEA | αα/--SEA | --SEA/--SEA | 97 | 61 | 61 | 15 | 15 |
α-thal F2 | F | 12wk 3d | 13.2 | αα/αα | αα/--SEA | αα/--SEA | 82 | 61 | 61 | 0d | 13 |
α-thal F3 | F | 18wk 2d | 7.7 | αα/--SEA | αα/--SEA | --SEA/--SEA | 87 | 61 | 61 | 11 | 16 |
α-thal F4 | M | 17wk 1d | 7.1 | αα/--SEA | αα/--SEA | αα/--SEA | 97 | 65 | 65 | 16 | 31 |
--SEA, Southeast Asian deletion.
aThis column displays the number of SNPs that overlap between the father and mother's haplotype blocks. These SNPs were used further in analyses to determine paternal and maternal inheritance.
bParental informative SNPs are those that are heterozygous in the father and homozygous in the mother. These SNPs were used to determine the fetal inheritance of the paternal variant.
cMaternal informative SNPs are those that are heterozygous in the mother regardless of whether the SNP is homozygous or heterozygous in the father. These SNPs were used to determine the fetal inheritance of the maternal variant.
dIn the family α-thal F2, the father was homozygous wild-type (αα/αα). The paternal inheritance was not tested since the fetus would certainly inherit a wild-type allele from its father.
Family . | Fetal sex . | Gestational age . | Fetal DNA fraction (%) . | Genotype . | Number of SNPs in the haplotype block adjacent to the SEA deletion determined by dHapSeq . | SNPs used in NIPT . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Father . | Mother . | Fetus . | Father . | Mother . | Overlappeda . | Paternal informativeb . | Maternal informativec . | ||||
α-thal F1 | M | 14wk 3d | 9.3 | αα/--SEA | αα/--SEA | --SEA/--SEA | 97 | 61 | 61 | 15 | 15 |
α-thal F2 | F | 12wk 3d | 13.2 | αα/αα | αα/--SEA | αα/--SEA | 82 | 61 | 61 | 0d | 13 |
α-thal F3 | F | 18wk 2d | 7.7 | αα/--SEA | αα/--SEA | --SEA/--SEA | 87 | 61 | 61 | 11 | 16 |
α-thal F4 | M | 17wk 1d | 7.1 | αα/--SEA | αα/--SEA | αα/--SEA | 97 | 65 | 65 | 16 | 31 |
Family . | Fetal sex . | Gestational age . | Fetal DNA fraction (%) . | Genotype . | Number of SNPs in the haplotype block adjacent to the SEA deletion determined by dHapSeq . | SNPs used in NIPT . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Father . | Mother . | Fetus . | Father . | Mother . | Overlappeda . | Paternal informativeb . | Maternal informativec . | ||||
α-thal F1 | M | 14wk 3d | 9.3 | αα/--SEA | αα/--SEA | --SEA/--SEA | 97 | 61 | 61 | 15 | 15 |
α-thal F2 | F | 12wk 3d | 13.2 | αα/αα | αα/--SEA | αα/--SEA | 82 | 61 | 61 | 0d | 13 |
α-thal F3 | F | 18wk 2d | 7.7 | αα/--SEA | αα/--SEA | --SEA/--SEA | 87 | 61 | 61 | 11 | 16 |
α-thal F4 | M | 17wk 1d | 7.1 | αα/--SEA | αα/--SEA | αα/--SEA | 97 | 65 | 65 | 16 | 31 |
--SEA, Southeast Asian deletion.
aThis column displays the number of SNPs that overlap between the father and mother's haplotype blocks. These SNPs were used further in analyses to determine paternal and maternal inheritance.
bParental informative SNPs are those that are heterozygous in the father and homozygous in the mother. These SNPs were used to determine the fetal inheritance of the paternal variant.
cMaternal informative SNPs are those that are heterozygous in the mother regardless of whether the SNP is homozygous or heterozygous in the father. These SNPs were used to determine the fetal inheritance of the maternal variant.
dIn the family α-thal F2, the father was homozygous wild-type (αα/αα). The paternal inheritance was not tested since the fetus would certainly inherit a wild-type allele from its father.
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